Platelet to Lymphocyte Ratio on Admission and Prognosis in Patients with Acute Cardiogenic Pulmonary Edema

Demir, Mevlüt; Duyuler, Pınar Türker; Güray, Ümit; Çelik, Muhammet Cihat

doi:10.1016/j.jemermed.2018.06.021

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…NLR has prognostic value in patients with HF presenting reduced or preserved ejection fraction 15,16 . Similarly, studies over the last decade have confirmed the prognostic value of PLR in different cohorts of HF patients 17,18 . Thus, there is powerful evidence supporting the potential prognostic value of SII in patients who undergo ICD implantation for HFrEF.…”

Section: Discussionmentioning

confidence: 89%

Evaluating systemic immune‐inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction

Hayıroğlu

Assoc

Çinier

et al. 2022

Pacing Clinical Electrophis

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Background Pro‐inflammatory pathways play an important role in the follow‐ups of patients with intracardiac defibrillators (ICDs) for heart failure (HF) reduced with ejection fraction (HFrEF). A newly defined index ‐ the systemic immune‐inflammation index (SII)—has recently been reported to have prognostic value in patients with cardiovascular disease. This study's aim is to evaluate the SII value regarding its association with long‐term mortality and appropriate ICD therapy during a 10‐year follow‐up. Methods This retrospective study included 1011 patients with ICD for HFrEF. The SII was calculated as the neutrophil—to—lymphocyte ratio × total platelet count in the peripheral blood. The study population was divided into two groups according to the SII's optimal cut‐off value to predict long‐term mortality. The long‐term prognostic impact of SII on these patients was evaluated regarding mortality and appropriate ICD therapy. Results The patients with a higher SII (≥1119) had significantly higher long‐term mortality and appropriate ICD therapy rates. After adjustment for all confounding factors, the long‐term mortality rate was 5.1 for a higher SII. (95% CI: 2.9–8.1). The long‐term appropriate ICD therapy rate was 2.0 for a higher SII (95% CI: 1.4–3.0). Conclusion SII may be an independent predictive marker for both long‐term mortality and appropriate ICD therapy in patients with HFrEF.

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Section: Discussionmentioning

confidence: 89%

Evaluating systemic immune‐inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction

Hayıroğlu

Assoc

Çinier

et al. 2022

Pacing Clinical Electrophis

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“…For example, Gomes et al [31] and Catalano [32] showed that 2 inflammatory cytokines in GDM, specifically interleukin-6 and tumor necrosis factor-α, were increased, while that of interleukin-10 was decreased. NLR and PLR have been introduced as inflammatory factors, and their associations with cardiovascular, pulmonary and other malignancies have been reported [33][34][35][36]. The findings of the Sahbaz et al [24] study suggested a significant correlation between increased levels in women with GDM compared with healthy pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Is there an association between platelet and blood inflammatory indices and the risk of gestational diabetes mellitus?

et al. 2020

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Objective Gestational diabetes mellitus (GDM) is the most prevalent medical complication in pregnancy. Early diagnosis of GDM can influence maternal/neonatal outcomes. To assess the association between platelet and blood inflammatory indices and the risk of GDM occurrence using the complete blood count (CBC) test. We also aimed to determine the sensitivity of each parameter for an early screening of this disorder during pregnancy. Methods This case-control study included 2 groups of 110 pregnant women with and without GDM. The women in each group were compared after the routine screening for GDM and after the CBC test at 24-28 weeks' gestation after being matched according to the inclusion criteria. Data were analyzed using SPSS version 16 and Medcalc version 14.8.1 software. Results There were statistically significant intergroup differences in white blood cell (WBC) count, platelet count, mean platelet volume (MPV), plateletcrit (PCT), MPV to platelet ratio, platelet to lymphocyte ratio, and Rh values. The values of lymphocyte count, neutrophil count, neutrophil to lymphocyte ratio, and blood group were not significantly different between groups. The logistic regression analysis showed the predictive values of WBC, platelet, MPV, and PCT in GDM. According to the receiver operating characteristic curve for all 3 variables, the level below the PCT chart was more than that of the others. Conclusion Increasing platelet and inflammatory indices on the CBC test in the second trimester of pregnancy seemed to be associated with the probability of GDM occurrence.

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“…After completion of follow-up duration, their findings suggested that higher tertiles were associated with higher total mortality (tertile 2/1: HR 2.730, 95% CI = 1.198–6.221, P = 0.017, tertile 3/1: HR 5.657, 95% CI = 2.467–12.969, P < 0.001). Although their study population had a quite similar mean age (69.3 ± 11.8 years) to ours, their small sample size and the recruitment of only a specific group of HF patients with probable worsen outcomes might limit the generalization of their findings [ 32 ]. Turcato et al .…”

Section: Discussionmentioning

confidence: 99%

The association between platelet-to-lymphocyte ratio with mortality among patients suffering from acute decompensated heart failure

Heidarpour

Bashiri

Vakhshoori

et al. 2021

BMC Cardiovasc Disord

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Background Platelet-to-lymphocyte ratio (PLR) is an inflammation index suggested to have the prognostic capability in heart failure (HF). We sought to investigate the association of PLR with cardiovascular disease (CVD) mortality and creatinine (Cr) rise among Iranian individuals suffering from acute decompensated HF (ADHF). Methods This retrospective cohort study was in the context of the Persian Registry Of cardioVascular diseasE/Heart Failure (PROVE/HF) study. 405 individuals with ADHF admitted to the emergency department were recruited from April 2019 to March 2020. PLR was calculated by division of platelet to absolute lymphocyte counts and categorized based on quartiles. We utilized the Kaplan–Meier curve to show the difference in mortality based on PLR quartiles. Cr rise was defined as the increment of at least 0.3 mg/dl from baseline. Cox proportional hazard ratio (HR) was used to investigate the association of PLR with CVDs mortality. Results Mean age of participants was 65.9 ± 13.49 years (males: 67.7%). The mean follow-up duration was 4.26 ± 2.2 months. CVDs mortality or re-hospitalization was not significantly associated with PLR status. Multivariate analysis of PLR quartiles showed a minimally reduced likelihood of CVDs death in 2nd quartile versus the first one (HR 0.40, 95% confidence interval (CI) 0.16–1.01, P = 0.054). Cr rise had no remarkable relation with PLR status in neither model. Conclusion PLR could not be used as an independent prognostic factor among ADHF patients. Several studies are required clarifying the exact utility of this index.

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Platelet to Lymphocyte Ratio on Admission and Prognosis in Patients with Acute Cardiogenic Pulmonary Edema

Cited by 17 publications

References 26 publications

Evaluating systemic immune‐inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction

Evaluating systemic immune‐inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction

Is there an association between platelet and blood inflammatory indices and the risk of gestational diabetes mellitus?

The association between platelet-to-lymphocyte ratio with mortality among patients suffering from acute decompensated heart failure

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