Platelet to lymphocyte ratio: A simple and valuable prognostic marker for acute coronary syndrome

Akkaya, Emre; Gül, Mehmet; Uğur, Murat

doi:10.1016/j.ijcard.2014.08.143

Cited by 46 publications

(39 citation statements)

References 10 publications

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“…The platelet-lymphocyte ratio (PLR) is new index being investigated for risk assessment for acute coronary syndromes [96]. The PLR is a metric that to combines the inflammatory potential of platelets, with decreased lymphocytes – a stress response that may reflect actions of cortisol[97, 98].…”

Section: Osa and Inflammation – Novel Biomarkersmentioning

confidence: 99%

Inflammation in sleep apnea: An update

Unnikrishnan

Jun

Polotsky

2014

Rev Endocr Metab Disord

165

118

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Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derangements during sleep in subjects with OSA further aggravate inflammation. In support of this theory, some clinical studies have shown elevated inflammatory biomarkers in OSA subjects, or improvement in these markers following treatment of OSA. However, the data are inconsistent and often confounded by the effects of comorbid obesity. Animal models of OSA have been developed, which involve exposure of rodents or cells to intermittent hypoxia, a hallmark feature of OSA. Several of these experiments demonstrate that intermittent hypoxia can stimulate inflammatory pathways and lead to cardiovascular or metabolic pathology. In this review, we review relationships between OSA and inflammation, with particular attention to studies published within the last year.

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Section: Osa and Inflammation – Novel Biomarkersmentioning

confidence: 99%

Inflammation in sleep apnea: An update

Unnikrishnan

Jun

Polotsky

2014

Rev Endocr Metab Disord

165

118

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“…Although counts of leukocytes and their subsets have been demonstrated to be associated with the severity of CAD (10), the relationship between PLR and CAD severity remains unclear. Furthermore, the majority of previous studies have focused on western patients (11)(12)(13). There are numerous differences between Western and Chinese populations, including environment and genetics, which may explain the differences observed in platelet counts and white blood cell counts between the two populations (14).…”

Section: Introductionmentioning

confidence: 99%

Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of percutaneous coronary intervention in the Chinese Han population

Zhou

Wang

Fan

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate whether the ratio of the absolute number of platelets to the number of lymphocytes (PLR) correlates with the severity of coronary artery disease (CAD) and major adverse cardiovascular disease (CVD) events in Chinese patients with CAD. PLR was calculated as follows: PLR=platelet count/lymphocyte count, using the complete blood counts of 854 Chinese Han subjects. CAD severity was determined using angiographic evidence by cardiologists unaware of the study aims. The association between PLR and CAD severity was analyzed by logistic regression. Clinical endpoints were evaluated during a median follow-up period of 42 months. The association between PLR and CVD events was assessed using Cox regression models. Patients with PLR>171 exhibited more severe coronary artery stenosis [odds ratio, 2.393; 95% confidence intervals (CI), 1.394-4.108; P=0.002] and worse prognoses, with a higher rate of major adverse CVD events during five years of follow-up (hazard ratio, 1.982; 95% CI, 1.329-2.957; P=0.001).A Kaplan-Meier curve demonstrated that the CVD event rate of 34.27% in patients with PLR>171 was significantly higher than that in patients with PLR<100 (P<0.001). These findings suggest that PLR is independently associated with CAD severity and long-term major adverse CVD events; therefore, high PLR may predict poor prognosis of CAD in the Chinese Han population.

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“…PLR has been recently suggested to be a marker of thrombotic and inflammatory condition. In the literature, it was shown that valvular heart diseases, acute coronary syndromes, hypertension, end-stage renal diseases, and other diseases may potentially affect the PLR [2][3][4][5][6]. In the study of Xing Li et al [1], patients with previous and/or secondary cancers were excluded, while such as heart diseases which is very common in old people (age 57 (19-86)) were not mentioned.…”

mentioning

confidence: 99%