Platelet-to-Lymphocyte Ratio

Liu, Wen-Yue; Lin, Shigang; Wang, Liren; Fang, Chen-Chen; Ying, Lin; Braddock, Martin; Zhu, Gui‐Qi; Zhang, Zhongheng; Zheng, Ming‐Hua; Shen, Feixia

doi:10.1097/md.0000000000002596

Cited by 26 publications

(10 citation statements)

References 34 publications

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“…NLR has also been shown to predict mortality in septic patients admitted to critical care (HR=1.043 (1.012-1.083)) [40]. PLR has been shown to be associated with mortality and length of stay in critically ill diabetic ketoacidosis patients [41]. This is perhaps another example of the differences in pathophysiology between burn injury and other critical illnesses and the importance of studying burn injury as a discrete entity.…”

Section: Discussionmentioning

confidence: 99%

Platelet count: A predictor of sepsis and mortality in severe burns

Cato

Wearn

Bishop

et al. 2018

Burns

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Section: Discussionmentioning

confidence: 99%

Platelet count: A predictor of sepsis and mortality in severe burns

Cato

Wearn

Bishop

et al. 2018

Burns

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“… 25 PLR describes the correlation between changes in levels of platelets and lymphocytes. PLR has been reported to play a significant role in cardiovascular diseases, 26 , 27 diabetic ketoacidosis, 28 and numerous neoplasms. 8 , 12 , 29 – 40 MPV reflects changes in either the level of platelet stimulation or the rate of platelet production.…”

Section: Introductionmentioning

confidence: 99%

Platelet distribution width as a prognostic factor in patients with COPD – pilot study

Białas¹,

Pedone²,

Piotrowski³

et al. 2017

COPD

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BackgroundPlatelets may actively participate in inflammation in COPD. Platelet distribution width (PDW), a measure of platelets’ volume heterogeneity, may increase in platelets’ activation. We hypothesized that PDW may be a marker of hypercoagulation, which plays a significant role in conditions associated with worse survival of patients with COPD, eg, acute myocardial infarction and other forms of ischemic heart disease.MethodsRetrospective analysis of 79 patients. Variables were compared after grouping patients according to the upper normal limit of PDW, using Welch’s t-tests or Mann–Whitney U, and chi-square tests. Survival in the two groups was compared using the Kaplan–Meier method and Cox proportional hazards regression.ResultsTen patients presented values of PDW above 16 fL, which was the upper limit of normality for our laboratory. Compared to patients with normal PDW, they had lower forced expiratory flow between 25% and 75% of vital capacity (FEF 25–75) – 35% of reference value vs 57% (P=0.003) and peak expiratory flow – 39% vs 54% (P<0.001). The median survival of patients with elevated PDW was 743 days compared to those with normal PDW (1,305 days) (P=0.025). The adjusted HR was 4.59 (95% CI: 1.1, 19.19; P=0.04).ConclusionOur analysis indicates that elevated PDW is associated with reduced survival of patients with COPD. If our data are to be confirmed, PDW may be used as an inexpensive and repeatable prognostic tool in COPD.

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“…11,12 Both NLR and PLR predict prognosis in critically ill patients, and in a range of conditions including Alzheimer disease, coronary heart disease, and COVID-19. [13][14][15] The diagnosis and monitoring of response to treatment of hand osteomyelitis are unique compared with osteomyelitis at other sites, yet existing evidence-based guidelines are tailored to long bones, for instance, recent fracturerelated infection guidelines, 16 and guidelines for the investigation of bone and soft tissue associated with HAND 18 (6) osteomyelitis, 17 so it is unclear how much they can be extrapolated to hand osteomyelitis.…”

Section: Introductionmentioning

confidence: 99%

Serum Inflammatory Markers and Amputations in Hand Osteomyelitis: A Retrospective Review of 146 Cases

Wyman

Dargan

Kazzazi

et al. 2022

Hand (New York, N,Y.)

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Background: The diagnosis of hand osteomyelitis requires correlation of clinical, radiological, and microbiological findings. The role of serum inflammatory markers in diagnosing and prognosticating hand osteomyelitis remains uncertain. We sought to determine the utility of inflammatory markers in the diagnosis and follow-up of hand osteomyelitis, and their ability to predict outcomes, particularly amputation. Methods: We retrospectively reviewed 146 patients diagnosed with hand osteomyelitis and with serum inflammatory marker levels measured after the onset of symptoms and within 14 days either side of diagnosis. Blood results at first presentation including white cell count (WCC), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) were reviewed, and associations with amputations assessed. Follow-up markers taken at 15 to 60 days from diagnosis were analyzed where available. Results: Mean WCC and CRP at diagnosis were 9.2 (SD: 4.6) and 30.2 (SD: 42.4) respectively, compared with 8.2 (SD: 3.9) and 30.2 (SD: 42.4) at follow-up. At diagnosis, sensitivity of CRP was 74%, and WCC was 31%. Each marker had a low positive predictive value for amputation at diagnosis (<29%). A rise in CRP between diagnosis and follow-up was associated with an increased risk of amputation compared with a fall in CRP. The finding that WCC and CRP were both normal at diagnosis had a high negative predictive value against amputation (96%). Discussion: C-reactive protein has a higher sensitivity than WCC, NLR, and PLR when used as a diagnostic adjunct in hand osteomyelitis. White cell count and CRP both within reference ranges at diagnosis was highly negatively predictive against amputation.

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Platelet-to-Lymphocyte Ratio

Abstract: Supplemental Digital Content is available in the text

Cited by 26 publications

References 34 publications

Platelet count: A predictor of sepsis and mortality in severe burns

Platelet count: A predictor of sepsis and mortality in severe burns

Platelet distribution width as a prognostic factor in patients with COPD – pilot study

Serum Inflammatory Markers and Amputations in Hand Osteomyelitis: A Retrospective Review of 146 Cases

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Platelet-to-Lymphocyte Ratio

Abstract: Supplemental Digital Content is available in the text

Cited by 26 publications

References 34 publications

Platelet count: A predictor of sepsis and mortality in severe burns

Platelet count: A predictor of sepsis and mortality in severe burns

Platelet distribution width as a prognostic factor in patients with COPD &ndash; pilot study

Serum Inflammatory Markers and Amputations in Hand Osteomyelitis: A Retrospective Review of 146 Cases

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Product

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Platelet distribution width as a prognostic factor in patients with COPD – pilot study