Platelet to lymphocyte and neutrophil to lymphocyte ratios as strong predictors of mortality in intensive care population

Karagöz, İbrahim; Yoldaş, Hamit

doi:10.1590/1806-9282.65.5.633

Cited by 20 publications

(22 citation statements)

References 20 publications

(6 reference statements)

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“…However, NLR was associated with mortality in unselected critically ill patients, including sepsis patients 15 . Additional studies have reported that NLR was associated with mortality in patients with sepsis [16][17][18][19][20] . Hwang et al demonstrated that septic shock patients at risk of early death had a low NLR and that late death was associated with an increased NLR 21 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil/lymphocyte ratio and mean platelet volume/platelet ratio for 1-year mortality in critically ill patients

Ham

Yoon

Nam

et al. 2020

Sci Rep

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Several studies have reported that the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) are associated with poor prognosis. This study investigated whether NLR and/or the MPV/platelet ratio could function as predictive markers of mortality in critically ill patients. We retrospectively reviewed 1,154 patients admitted to the intensive care unit (ICU) between January 2017 and December 2017. Patients were divided into 2 groups according to 1-year mortality. We compared the NLR and MPV/platelet ratio on each day of ICU admission. Patients were classified into tertiles based on their NLR and MPV/platelet ratios, and the incidence of 1-year mortality was compared. Kaplan–Meier survival curves were plotted to evaluate their potential as prognostic factors for 1-year mortality. The NLR and MPV/platelet ratio were higher in the non-survivor group than in the survivor group. The incidence of 1-year mortality was the highest in the third tertile for both the NLR and MPV/platelet ratio. The MPV/platelet ratio was an independent predictor for 1-year mortality based on the Kaplan–Meier survival analysis. Our data showed that the MPV/platelet ratio is a predictive factor for 1-year mortality in critically ill patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil/lymphocyte ratio and mean platelet volume/platelet ratio for 1-year mortality in critically ill patients

Ham

Yoon

Nam

et al. 2020

Sci Rep

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“…Rasio neutrofil limfosit pada semua pasien yang dirawat di ruang ICU meningkat disebabkan karena respons stres peradangan penyakit yang mendasarinya. 9 Pada distribusi subjek berdasarkan jenis kelamin terhadap mortalitas terdapat sebanyak 48,2% subjek yang berjenis kelamin laki-laki dan 51,8% subjek yang berjenis kelamin perempuan pada kelompok yang meninggal, sedangkan terdapat sebanyak 38,6% subjek yang berjenis kelamin lakilaki dan 61,4% subjek yang berjenis kelamin perempuan pada kelompok yang hidup. Pada distribusi subjek berdasar jenis kelamin terhadap rasio neutrofil limfosit, terdapat rerata rasio neutrofil limfosit pada kelompok laki-laki dan perempuan adalah 14,84±11,91 dan 15,09±12,81.…”

Section: Pendahuluanunclassified

“…(AUC: 0,80, p<0,001). 9 Rasio neutrofil limfosit dapat digunakan sebagai penanda inflamasi dalam praktik perawatan intensif karena respons fisiologis leukosit yang bersirkulasi terhadap stres inflamasi menyebabkan peningkatan jumlah neutrofil dan penurunan jumlah limfosit.…”

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Hubungan Rasio Neutrofil Limfosit dengan Mortalitas ≤28 hari di General Intensive Care Unit RSUP Dr. Mohammad Hoesin Palembang

Riandy¹,

Purba²,

Puspita³

et al. 2019

jap

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AbstrakRasio neutrofil limfosit adalah metode yang cepat dan sederhana untuk mengevaluasi stres peradangan dan memprediksi mortalitas di ruangan intensif. Penelitian ini bertujuan mengetahui hubungan rasio neutrofil-limfosit dengan mortalitas ≤28 hari di ruangan rawat intensif. Penelitian ini menggunakan desain penelitian cross sectional berdasarkan data sekunder rekam medis dengan sampel semua pasien yang dirawat di ICU RSUP Dr. Mohammad Hoesin Palembang dari Januari-Desember 2018. Didapatkan total sampel sebanyak 562 sampel, dan sebanyak 347 yang memenuhi kriteria inklusi. Pada uji analisis regresi diagnosis, kelompok usia, jenis kelamin dan terapi terhadap nilai rasio neutrofil limfosit, didapatkan bahwa diagnosis merupakan faktor risiko yang dapat memengaruhi nilai rasio neutrofil limfosit (p=0,001). Pada distribusi subjek berdasarkan rasio neutrofil limfosit terhadap mortalitas terdapat rerata rasio neutrofil limfosit pada kelompok yang meninggal adalah 17,75±15,06 dan rerata rasio neutrofil limfosit subjek pada kelompok yang hidup adalah 13,63±10,71. Dilakukan Uji Mann-Whitney dan didapatkan bahwa terdapat perbedaan rerata antara rasio neutrofil limfosit antara kelompok yang hidup dan meninggal dengan nilai p=0,009. Simpulan, rasio neutrofil limfosit merupakan salah satu biomarker yang dapat memprediksi mortalitas pada pasien di ICU RSUP Dr. Moh. Hoesin Palembang. AbstractNeutrophil lymphocyte ratio is a fast and simple method for evaluating inflammatory stress and predicting mortality in intensive care. The purpose of this study was to determine the relationship between the ratio of neutrophils to lymphocytes to ≤28 day mortality in the intensive care unit. This was a crosssectional study on secondary data collected from medical records of all patients treated at the ICU of Dr. Mohammad Hoesin General Hospital Palembang during the period of January-December 2018. A total sample of 562 samples was obtained and 347 of them met the inclusion criteria. When diagnosis, age group, gender, and therapy for neutrophil-lymphocyte ratio value were subjected to regression analysis, it was revealed that diagnosis was a risk factor that could affect the neutrophil-lymphocyte ratio value (p=0,001). When subject distribution was assessed based on neutrophil lymphocyte ratio to mortality, an average neutrophil lymphocyte ratio of 17.75±15.06 was observed in the deceased group while the average ratio in survived patients was 13.63±10.71. Mann-Whitney test was then performed and a difference in the neutrophil to lymphocyte ratio was found between the survived and deceased groups with a p value of 0.009. In conclusion, neutrophil to lymphocyte ratio can be used as one of the biomarkers that can predict mortality in patients treated in intensive care unit.

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“…It has been suggested that these parameters are associated with the presence and severity of coronary artery disease (CAD) and may predict future coronary events and mortality. [3][4][5][6][7][8][9][10][11] Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and ischemia-modified albumin (IMA) are oxidative stress parameters. It has been shown that oxidative stress has an important role in the pathogenesis of atherosclerosis and CAD, and high oxidant levels reflect disease severity and vascular damage.…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that these parameters are associated with the presence and severity of coronary artery disease (CAD) and may predict future coronary events and mortality. 3 –11…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Inflammation Parameters in Patients With Non-ST Elevation Acute Coronary Syndromes

Güçlü

Çelik

2020

Angiology

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Inflammation parameters can predict the severity of coronary artery disease and predict long-term mortality. However, there is no study in which these parameters were evaluated together. We compared the prognostic values of inflammation parameters in predicting long-term mortality in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). Consecutive patients with NSTE-ACS (n = 170) were included in the study. Monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR), lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), total cholesterol/HDL-C ratio (TC/HDL-C), triglyceride /HDL-C ratio (TG/HDL-C), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, and ischemia-modified albumin (IMA) were measured. Total antioxidant status and TOS variables were significant independent predictors of mortality. When 1.17 value is taken as a cutoff point of TAS values, the sensitivity (70.0%) and specificity (77.39%) values calculated for this value indicate that TAS variable has a predictive value on mortality. Monocyte/high-density lipoprotein cholesterol ratio, LMR, NLR, PLR, TC/HDL-C, TG/HDL-C, TOS, and IMA levels could not be used alone in the diagnosis, severity assessment, and predicting future mortality of NSTE-ACS. Only TAS levels had a predictive value on mortality.

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Platelet to lymphocyte and neutrophil to lymphocyte ratios as strong predictors of mortality in intensive care population

Cited by 20 publications

References 20 publications

Prognostic value of neutrophil/lymphocyte ratio and mean platelet volume/platelet ratio for 1-year mortality in critically ill patients

Prognostic value of neutrophil/lymphocyte ratio and mean platelet volume/platelet ratio for 1-year mortality in critically ill patients

Hubungan Rasio Neutrofil Limfosit dengan Mortalitas ≤28 hari di General Intensive Care Unit RSUP Dr. Mohammad Hoesin Palembang

Prognostic Value of Inflammation Parameters in Patients With Non-ST Elevation Acute Coronary Syndromes

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