Platelet storage: Progress so far

Vani, R.; Rajanand, Magdaline Christina

doi:10.1007/s11239-022-02716-3

Cited by 7 publications

(3 citation statements)

References 100 publications

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“…There is a crucial need for platelet transfusion during emergency-surgery and treatment of platelet disorders. 37 Platelet components can be prepared by different methods such as AP, PRP and BC. Studies have demonstrated that the quality of platelet components was influenced by almost all the steps from the donors to the patients, including donors' characteristics, collection, processing, storage conditions and so on.…”

Section: Discussionmentioning

confidence: 99%

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Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat

Li,

Zhao,

Chen

et al. 2024

Transfusion

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BackgroundPlatelet concentrates (PCs) could be prepared using either whole‐blood processes or apheresis instruments. During collection, processing and storage, some biochemical and functional changes occur, which may result in quality reduction. Quality evaluation of PCs may be helpful for the precise control of platelet (PLT) inventory to reduce the risk of refractoriness and adverse effects caused by platelet transfusion.Study Design and MethodsThe study was aimed to evaluate the quality of PCs which were produced by five processes: apheresis (AP) procedures (using three different cell separators: Amicus, Trima Accel and MCS+ instruments), platelet rich plasma (PRP), and buffy coat (BC). A total of 100 PCs (20 of each group) were assessed in respect of routine quality control, morphology, size distribution, destroyed and activated platelets, and production of platelet‐derived microparticles (PMPs).ResultsAll PCs have satisfied the recommended quality of volume, platelet count, residual WBC count, residual RBC count, pH, and sterility according to the Chinese Technical Manual. There was no difference among the 5 groups in morphology and size of PLT and PMPs. Dynamic light scattering test showed that apheresis PCs showed peaks around 10–20 nm, but not whole blood‐derived PCs. PCs prepared by Amicus had the relatively high percentage of destroyed platelet, activated platelets and PMPs than other groups.DiscussionThe data suggested high heterogeneity of PMPs, destroyed and activated platelets in PCs produced by different processes, which might be helpful to manage the platelet inventory for targeted use.

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Section: Discussionmentioning

confidence: 99%

“…There is a crucial need for platelet transfusion during emergency‐surgery and treatment of platelet disorders 37 . Platelet components can be prepared by different methods such as AP, PRP and BC.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat

Li,

Zhao,

Chen

et al. 2024

Transfusion

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“…PSL is an irreversible process that results in limited shelf life, decline in quality, and loss of function of the platelets. 44 It is of significant clinical value to explore an effective method to mitigate PSL and extend the shelf life of the stored platelets. It will help reduce waste and increase the treatment efficacy of platelets in clinical use.…”

Section: ■ Discussionmentioning

confidence: 99%

Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect

Hou,

Xiong,

Shao

et al. 2023

ACS Appl. Mater. Interfaces

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Platelet transfusion is essential in the treatment of platelet-related diseases and the prevention of bleeding in patients with surgical procedures. Platelet transfusion efficacy and shelf life are limited mainly by the development of platelet storage lesion (PSL). Mitigating PSL is the key to prolonging the platelet shelf life and reducing wastage. Excess intracellular reactive oxygen species (ROS) are one of the main factors causing PSL. In this study, we explored a nanomedicine strategy to improve the quality and functions of platelets in storage. Resveratrol (Res), a natural plant product, is known for its antioxidative effect. However, medical applications of Res are limited due to its low water solubility and stability. Therefore, we used a resveratrol-loaded liposomal system (Res-Lipo) to better utilize the antioxidant effect of the drug. This study aimed to evaluate the effect of Res-Lipo on platelet oxidative stress and alleviation of PSL during the storage time. Res-Lipo scavenged intracellular ROS and inhibited platelet apoptosis and activation during storage. Res-Lipo not only maintained mitochondrial function but also improved platelet aggregation in response to adenosine 5′-diphosphate. These results revealed that Res-Lipo ameliorated PSL and prolonged the platelet survival time in vivo. The strategy provides a potential method for extending the platelet storage time and might be considered a potential and safe additive to alleviate PSL.

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A peptide-engineered alginate aerogel with synergistic blood-absorbing and platelet-binding capabilities to rapidly stop bleeding

Liu

Shi

et al. 2023

Carbohydrate Polymers

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Platelet storage: Progress so far

Cited by 7 publications

References 100 publications

Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat

Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat

Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect

A peptide-engineered alginate aerogel with synergistic blood-absorbing and platelet-binding capabilities to rapidly stop bleeding

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