Platelet serotonin uptake in panic disorder

Norman, Trevor R.; Judd, Fiona; Gregory, Margaret S.; James, R H; Kimber, Nigel M.; McIntyre, Iain M.; Burrows, Graham D.

doi:10.1016/0165-0327(86)90062-5

Cited by 40 publications

(14 citation statements)

References 12 publications

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“…The extent to which this test is a marker of serotonergic function has been disputed [9]. Several studies of platelet 3H-imipramine binding, a reputed indicator of presynaptic serotonergic function, have failed to demonstrate differences between panic patients and controls [lo-131. Nevertheless, in accord with a substantial body of clinical and experimental data, we demonstrated an increased platelet serotonin uptake in panic patients compared to a control group [14]. The changes observed were due entirely to an increased rate of serotonin uptake (Vmax), while the affinity of the transporter for serotonin (Km) was not different.…”

supporting

confidence: 82%

Platelet Serotonin Uptake in Panic Disorder: Comparison with Normal Controls and the Effect of Treatment

Norman

Gregory

Judd

et al. 1988

Aust N Z J Psychiatry

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Platelet serotonin uptake was measured in 59 patients with panic attacks and compared to 26 controls. Scatchard analysis of the data showed that the maximal rate of uptake (Vmax) of serotonin was significantly higher in patients than controls. The affinity constant (Km) was not different. In a sub-group of 24 patients, benzodiazepine treatment did not alter the kinetics of platelet serotonin uptake. These findings suggest an abnormality in serotonergic function in patients with panic attacks. Insofar as the platelet is a model of central neuronal function they support serotonergic hyperactivity as a biochemical basis of panic attacks.

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supporting

confidence: 82%

Platelet Serotonin Uptake in Panic Disorder: Comparison with Normal Controls and the Effect of Treatment

Norman

Gregory

Judd

et al. 1988

Aust N Z J Psychiatry

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“…Although some evidence of cytokine disturbance in panic disorder exists (involving reports of increased interleukin-1β [30] and IL-2 plasma concentrations [31] in panic disorder compared with controls), overall the evidence is as yet insufficient to underpin an association with hypertension.…”

Section: Other Putative Mechanismsmentioning

confidence: 91%

“…In more controlled conditions, the Trier social stress test, which is an acute psychological stressor designed as a laboratory probe of social anxiety symptoms, has been consistently reported to produce a transient increase in plasma IL-6 [64] and IL-1β [65]. As noted earlier, some evidence exists for elevated IL-6 and IL-2 in panic disorder [30,31]. However, although the possibility that cytokines may be responsible for the association of anxiety disorders with ischemic heart disease is still to be fully investigated, there have been some recent intriguing reports which suggest that immune functioning may link risk factors for cardiovascular disease and anxiety (or at least psychological stress).…”

Section: Mechanisms In the Association Of Coronary Heart Disease And mentioning

confidence: 94%

Anxiety and Cardiovascular Disease

Davies

Allgulander

2013

Modern Trends in Psychiatry

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This chapter examines the association of anxiety disorders and anxiety symptoms with cardiovascular disease, focussing on hypertension (an independent risk factor for myocardial infarction and stroke) and coronary heart disease. In both cases, epidemiological data linking the cardiovascular disorder with specific anxiety disorders and anxiety symptoms are examined first, and evidence relating to putative mechanisms that may underlie these associations is explored. For hypertension, an association with panic attacks and panic disorder has been reported most consistently, but the literature relating to other forms of anxiety is inconsistent, especially as some studies have reported an association of anxiety with low blood pressure. Recent work which has attempted to elucidate this confusing situation is presented. Mechanisms which may be responsible for the link between hypertension and panic include autonomic nervous system dysfunction (which may be under serotonergic control), respiratory mechanisms, cytokines, platelet dysfunction and behavioural factors. While an association of depression with coronary heart disease has been studied extensively, the association with anxiety disorders has been slower to emerge. Studies contributing to this evidence base are examined, and as for hypertension putative mechanisms are discussed.

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“…Many researches have concluded that altered 5-HTT function and abnormalities in heart rate variability (HRV) are characteristics of panic disorder (5, 6, 10, 12, 13, 22). However, the relationship between platelet 5-HTT function and HRV in panic disorder has yet to be known.…”

Section: Discussionmentioning

confidence: 99%

“…There have been contradictory findings on the 5-HTT function in panic disorder (12, 13, 23). In the present study, platelet 5-HT uptake maximal velocity (V max ) and its associated affinity constant (K m ) were found to be lower (i.e.…”

Section: Discussionmentioning

confidence: 99%

Platelet Serotonin Transporter Function and Heart Rate Variability in Patients with Panic Disorder

Kang

Lee

Park³

et al. 2010

J Korean Med Sci

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Many studies showed abnormal serotonin transporter (5-HTT) function and heart rate variability (HRV) in panic disorder patients. The present study investigated the relationship between HRV power spectral analysis findings and platelet serotonin uptake in panic disorder patients. Short-term HRV over 5 min and platelet serotonin transporter uptake parameters (Vmax and Km) were measured both in 45 patients with panic disorder and in 30 age-matched normal healthy control subjects. Low frequency power (LF) normalized unit (nu) and LF/high frequency power (HF) were significantly higher, whereas HF and HF nu were lower in the patient group than in the control group. Vmax and Km were all significantly lower (i.e., reflects decreased 5-HTT function) in patients with panic disorder than in normal controls. In the patient group, Km was negatively correlated with LF/HF and LF nu whereas no such correlations between them were found in the control group. By multivariate analysis based on multiple hierarchical linear regression, a low Km independently predicted an increased LF nu even after controlling for age, sex, and body mass index in the patient group. These results suggest that impaired 5-HTT function is closely related to dysregulation of autonomic nervous system in panic disorder.

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Platelet serotonin uptake in panic disorder

Cited by 40 publications

References 12 publications

Platelet Serotonin Uptake in Panic Disorder: Comparison with Normal Controls and the Effect of Treatment

Platelet Serotonin Uptake in Panic Disorder: Comparison with Normal Controls and the Effect of Treatment

Anxiety and Cardiovascular Disease

Platelet Serotonin Transporter Function and Heart Rate Variability in Patients with Panic Disorder

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