Platelet Serotonin Measures in Migraine

Jernej, Branimir; Vladić, Anton; Čičin‐Šain, Lipa; Hranilović, Dubravka; Banović, Miroslav; Balija, Melita; Bilić, Ervina; Sučić, Zvonimir; Vukadin, Stjepan; Grgicević, D

doi:10.1046/j.1526-4610.2002.02145.x

Cited by 19 publications

(19 citation statements)

References 48 publications

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“…Biochemical studies of MAO-B in migraine, including our recent study [27], mostly failed to show a correlation between platelet MAO activity and this disorder [29]. The reason could be the different regulation of the enzyme activity in the blood cells vs. the brain [30], supported also by the lack of intraindividual correlation between platelet and brain MAO-B activity [31,32].…”

Section: Discussionmentioning

confidence: 99%

“…Preparation of platelet-rich plasma (PRP) was done by the method described previously [27]. Enzyme velocity was expressed as nanomoles 4-HQ per 10 8 platelets per 60 min and K M as AM concentration of kynuramine.…”

Section: Measurement Of Platelet Mao-b Activitymentioning

confidence: 99%

“…Our previous work on the migraine was focused, by the use of platelet model, on the MAO activity [27]. The present study investigates the association of migraine with polymorphisms in MAO-A and -B genes.…”

Section: Introductionmentioning

confidence: 98%

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Monoamine oxidases A and B gene polymorphisms in migraine patients

Filić

Vladić

Štefulj

et al. 2005

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Platelet Mao-b Activitymentioning

confidence: 99%

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Monoamine oxidases A and B gene polymorphisms in migraine patients

Filić

Vladić

Štefulj

et al. 2005

Journal of the Neurological Sciences

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“…22 However, conflicting evidence for platelet dysfunction has been reported in migraine. 23,24 Urinary excretion of the main metabolite of 5-HT, 5-hydroxyindoleacetic acid, decreases with the frequency of migraine attacks. Other investigations have shown decreased whole blood levels of 5-HT in patients with CDH and medication overuse and increase in serotonin levels with improvements in headache frequency and resolution of overuse.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Effects on Sleep and Emotional Disorders in Adolescent Migraine

Pakalnis

Splaingard²,

Splaingard³

et al. 2009

Headache

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Objective To determine frequency of emotional disorders and sleep disturbances in adolescent migraineurs with episodic and chronic headaches. To determine the relationship of whole blood serotonin, caffeine consumption, and frequency of sleep and mood disorders. Background The neurotransmitter serotonin has been implicated to play a role in the initiation and maintenance of sleep and in modulating mood. A putative role in migraine pathophysiology is also known. Methods Adolescents from 13 to 17 years of age were identified from our headache clinic with episodic or chronic migraine (according to International Classification of Headache Disorders-Second Edition criteria) and healthy controls enrolled. Psychological rating scales were completed, including Adolescent Symptom Inventory (4th Edition) and Child Depression Inventory. Sleep questionnaires (Pediatric Sleep Questionnaire and Child Sleep Habit Questionnaire) were completed by the teenager’s parents/guardian. Whole blood serotonin levels were drawn and analyzed and caffeine consumption obtained by history. Results A total of 18 controls (8 girls) and 15 patients each with episodic migraines (9 girls) and chronic migraine (10 girls) were studied. Patients with headache had significantly more sleep problems than controls. Patients with chronic migraines had increased daytime sleepiness and dysthymia compared with teenagers with episodic migraines. Serotonin levels were not significantly different, and no association was noted between serotonin levels and sleep abnormalities or emotional rating scales. Increased caffeine intake was related to sleep and depressive complaints. Conclusions Sleep and emotional disorders were common in adolescents with migraine. Sleep disorders and dysthymia were more prevalent with increased headache frequency. No correlation was noted with whole blood serotonin levels.

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“…6 Serotonin depletion was believed to affect platelet function, resulting in a loss of vascular tone. 7,8 Serotonin is a vasoconstrictor and experimentally alleviates headache, although in its non-selective form it has numerous undesirable adverse events (AEs), such as bronchoconstriction, gastrointestinal effects, and generalized vasoconstriction. 9 Triptans cause fewer AEs, since they have a specific receptor affinity.…”

Section: Triptans: An Overviewmentioning

confidence: 99%

Zolmitriptan and the Triptan Era

Marmura

2009

Clinical Medicine. Therapeutics

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Zolmitriptan is one of seven triptans available to treat acute migraine attacks. The introduction of these selective serotonin receptor agonists almost 20 years ago has revolutionized acute migraine treatment. Triptans are now first line migraine drugs, and provide acute treatment that is well-tolerated, safe and effective. This commentary reviews the use of zolmitriptan and other triptans, discusses how to maximize their effect, and examines the controversies surrounding this class of medication such as medication-overuse headache, use in migraine aura or prodrome, pediatric use, and important drug interactions.

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Platelet Serotonin Measures in Migraine

Abstract: Our results indicate the absence of a measurable disturbance in 5HT homeostasis in migraine, as shown by platelet 5HT parameters, and they question the suitability of the use of mentioned blood elements in this regard.

Cited by 19 publications

References 48 publications

Monoamine oxidases A and B gene polymorphisms in migraine patients

Monoamine oxidases A and B gene polymorphisms in migraine patients

Serotonin Effects on Sleep and Emotional Disorders in Adolescent Migraine

Zolmitriptan and the Triptan Era

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