Platelet Serotonin as Biomarker for Assessing Suicidal Behaviour in Patients with Bipolar I Disorder

Giurgiuca, Ana; Schipor, Sorina; Caragheorgheopol, Andra; Crasan, A.; Postolache, E; Tudose, Cătălina; Prelipceanu, Dan; Cozman, Doina

doi:10.4183/aeb.2016.275

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Our results are in line with current research findings that support higher cortisol levels in individuals with suicidal ideation (35,36) and submit to the allostatic hypothesis age-dependent maladaptive responses of the HPA axis to stress exposure overtime (28) and with recent scientific literature which correlates high suicide risk with a hyperactive HPA axis in younger individuals, that later downregulates with age, after chronic exposure (21).…”

Section: Discussionsupporting

confidence: 93%

“…These findings are in line with the allostatic load theory that postulates agedependent maladaptive responses of the HPA axis to stress exposure overtime (28) and with recent scientific literature which correlates high suicide risk with a hyperactive HPA axis in younger individuals, that later down-regulates with age, after chronic exposure (21). Results of the association between suicidal behaviour, platelet serotonin (35), or cortisol levels were also highlighted in other research studies (36). Even though our research did not reveal any significant correlations between suicide attempts and cortisol levels in BPD I, the data shows trends that reflect a relationship that should be further explored with larger samples size.…”

Section: Discussionsupporting

confidence: 89%

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Cortisol Levels and Suicide in Bipolar I Disorder

et al. 2017

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Context. Hypothalamic-pituitary-adrenal (HPA) axis irregularities have been described both in bipolar disorder and suicidal behaviour, but few studies have examined the relationship between suicidal behaviours and cortisol levels in bipolar disorder.Objective. We compared HPA axis activity in bipolar I (BPD I) individuals with and without suicidal ideation and behaviour through multiple measurement of serum and salivary cortisol.Design. Cross-sectional, observational study. Subjects and Methods. 75 BPD I patients were assigned into 3 groups (no history of suicidal behaviour, history of suicidal ideation, history of suicide attempt), according to the C-SSRS. Socio-demographical and clinical data was obtained by using MINI 6.0 and a semi-structured questionnaire. Salivary samples were collected using Sarstedt Cortisol Salivette synthetic swab system for two consecutive days at 08:00, 16:00, 23:00 and salivary cortisol concentrations were determined by ELISA technique. A unique 1mg dose of dexamethasone was administered on the first day, at 23:00, after the collection of the saliva sample. Blood was collected on the first day at 8:00 AM and basal morning serum cortisol levels were determined by immunoassay with fluorescence detection.Results. Cortisol parameters in our BPD I sample did not vary significantly in respect to suicidal history. However, patients with a history of suicidal ideation have significantly higher total cortisol outputs than patients with no history of suicidal behaviour in the 18 to 40 age category compared with the above 40 age category.Conclusions. Total cortisol daily output varies significantly in an age-dependent manner in respect to suicidal thoughts in BPD I individuals.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Cortisol Levels and Suicide in Bipolar I Disorder

et al. 2017

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“…In turn, the aggressivity and impulsivity of suicidal attempters seem associated with serotonin content and the total number of 5-HT 2A receptors on platelet surface [ 39 ]. A recent study showed significantly lower levels of platelet serotonin in suicide attempters compared to non-attempters and high- vs. low-lethality attempters, respectively [ 40 ]. Therefore, a strict interplay between platelet levels, serotonin, psychopathological features of (hypo)mania, and suicide in patients with BD could be hypothesized.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder

et al. 2021

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Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes. Methods: We recruited 294 patients affected by BD, of which 143 were experiencing a (hypo)manic episode and 151 were in a depressive phase. A blood sample was drawn to perform a complete blood count. NLR, PLR, and MLR were subsequently calculated. A t-test was performed to evaluate differences in blood cell counts between depressed and (hypo)manic patients and a regression model was then computed. Results: Mean values of neutrophils, platelets, mean platelet volume, NLR, PLR, and MLR were significantly higher in (hypo)manic than depressed individuals. Logistic regression showed that PLR may represent an independent predictor of (hypo)mania. Conclusions: Altered inflammatory indexes, particularly PLR, may explain the onset and recurrence of (hypo)manic episodes in patients with BD. As inflammatory ratios represent economical and accessible markers of inflammation, further studies should be implemented to better elucidate their role as peripheral biomarkers of BD mood episodes.

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“…Furthermore, it was recently established that low serotonin levels in plasma were associated with patients with a low response to antidepressant treatment, presenting depressive symptoms (Holck et al, 2019). Additionally, platelets with low serotonin levels are a reliable biomarker in suicide risk assessment (Giurgiuca et al, 2016). Thus, lower levels of serotonin in plasma suggest an increased presence of depressive symptoms according to the CESD-20 score.…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms are Associated with low Serotonin Levels in Plasma but are not 5–HTTLPR Genotype Dependent in Older Adults

et al. 2021

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Depressive symptoms are diagnosed by physicians using scales but their pathophysiology is unclear. Low serotonin (5–HT) levels play an important role in depression, and the 5–HT transporter (5–HTT) is an important regulator of plasma serotonin levels and reuptake. Additionally, the 5–HTT gene-linked polymorphic region (5–HTTLPR) is associated with depression. The aim was to clarify the roles of plasma serotonin levels in plasma and the 5HTTPLR polymorphism in depressive symptoms in older adults. A total of 84 older adult participants were evaluated. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale of 20 items (CESD–20). The plasma serotonin levels were determined by ELISA, and the 5–HTTLPR genotype was analyzed by PCR. Depressive symptoms were present in 39.3% (N = 33) of the participants. The median plasma serotonin level was 204.34 ng/mL (SD = 93.88). A significant correlation was found between the CESD–20 scale and plasma serotonin levels (r = –.256; p = .019). Low serotonin levels were associated with the presence of depressive symptoms (p = .001). The 5–HTTLPR analysis showed that of the 84 older adults, 35.7% had the SS genotype, 10.7% had the LL genotype, and 53.6% were heterozygous. The 5–HTTLPR polymorphism was not associated with depressive symptoms (p = .587) and plasma serotonin levels (p = 0.391). Depressive symptoms correlate with low serotonin levels in plasma, but not with the 5–HTTLPR polymorphism in older Mexican adults.

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Platelet Serotonin as Biomarker for Assessing Suicidal Behaviour in Patients with Bipolar I Disorder

Cited by 9 publications

References 36 publications

Cortisol Levels and Suicide in Bipolar I Disorder

Cortisol Levels and Suicide in Bipolar I Disorder

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder

Depressive Symptoms are Associated with low Serotonin Levels in Plasma but are not 5–HTTLPR Genotype Dependent in Older Adults

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