Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients

Zhuang, Xiaoyin; Xu, Haiyun; Zeman, Florian; Xu, Chongtao; Xue, Chaobiao; Hong, Xiaohong

doi:10.1016/j.ejphar.2018.07.033

Cited by 33 publications

(20 citation statements)

References 56 publications

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“…Platelets are a popular model in psychiatric disorders because they display serotonergic parameters similar to those in the central nervous system e.g. serotonin receptors as well as the serotonin transporter and the fact that they store over 80% of the peripheral serotonin (Stahl 1985;Muck-Seler et al 2004;Zhuang et al 2018). Since platelets also have an important role in the immune system, they may serve as an easily accessible tool to investigate mental stress induced proinflammatory states.…”

Section: Introductionmentioning

confidence: 99%

Stress Enhances Proinflammatory Platelet Activity: the Impact of Acute and Chronic Mental Stress

Koudouovoh-Tripp

Hüfner

Egeter

et al. 2020

J Neuroimmune Pharmacol

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The role of platelets in hemostasis and thrombosis has long been recognized, recently their contribution to immunological and inflammatory processes is emerging. Platelets could be the missing link between cardiovascular disease, chronic stress and depressive symptoms. Both physical and mental stressors cause platelet activation reflected by changes in platelet bioactivity and aggregation. Here we evaluate the proinflammatory platelet response to acute and chronic mental stress. In a prospective study design an acute mental stress test was administered to 55 healthy male participants once without and once in the presence of chronic mental stress. Blood was collected prior to and at three time points following an acute mental stress test (0, 30, 60 min). Platelet proinflammatory activation markers, were assessed using FACS analysis and aggregability was measured in response to ADP or epinephrine using PFA-100. A linear mixed model was used for analysis. Chronic mental stress lead to a significant increase in state anxiety (p < 0.001), depressive symptoms (p = 0.045) and perceived stress (p = 0.001). The factor "chronic mental stress" was significantly associated with increased numbers of CD63+ platelets (p = 0.009). The factor "acute mental stress" was associated with alterations in CD62P+ platelets (p < 0.001), CD63+ platelets (p = 0.011), PAC-1+ platelets (p < 0.001) as well as platelet leucocyte aggregates (p = 0.019). The recovery of CD62P function following the acute mental stress exposure was significantly impaired by chronic stress (p = 0.023). Aggregation was affected by chronic and acute mental stress. In conclusion, mental stress is linked to an increased and prolonged proinflammatory platelet bioactivity. This proinflammatory and immunomodulatory stimuli could help to explain the link between mental and somatic disorders.

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Section: Introductionmentioning

confidence: 99%

Stress Enhances Proinflammatory Platelet Activity: the Impact of Acute and Chronic Mental Stress

Koudouovoh-Tripp

Hüfner

Egeter

et al. 2020

J Neuroimmune Pharmacol

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“…An extensively investigated molecule in the relation between depression and platelets activation is the serotonin (5-HT) [ 28 , 29 ]. Platelets share with serotoninergic neurons several similarities in 5-HT uptake, storage, metabolism and release mechanisms, representing a good surrogate to study neuropsychiatric research [ 30 ]. Of note, platelets from depressed patients show a greater aggregation in response to 5-HT [ 31 , 32 , 33 ], display enhanced platelet serotonin uptake [ 30 ], that favors platelet response to ADP [ 34 ], and an increased platelet 5-HT 2 receptor binding and density [ 35 , 36 ] ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…Platelets share with serotoninergic neurons several similarities in 5-HT uptake, storage, metabolism and release mechanisms, representing a good surrogate to study neuropsychiatric research [30]. Of note, platelets from depressed patients show a greater aggregation in response to 5-HT [31][32][33], display enhanced platelet serotonin uptake [30], that favors platelet response to ADP [34], and an increased platelet 5-HT 2 receptor binding and density [35,36] (Figure 1). Despite the already proved importance of 5-HT in this contest also other circulating molecules may be involved.…”

Section: Introductionmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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“…e GV20 acupoint has benign regulatory effects on the nervous, endocrine, and immune systems [11,12]; GV29 also has regulatory effects on the nervous system, causing the release of neurotransmitters such as serotonin (or 5-hydroxytryptamine (5-HT)) [13], which is widely distributed in the central nervous system (CNS) and is known to be associated with depression [14][15][16]. As a monoamine neurotransmitter and neuromodulator in central information processing, 5-HT has been reported to influence a range of behavioral, physiological, and cognitive functions such as memory, mood, emotions, sleep, and appetite [17]. About 5% of all 5-HT within the body is produced in serotonergic neurons of the CNS and released into synapse [18].…”

Section: Introductionmentioning

confidence: 99%

“…ere have been studies investigating the relationship of 5-HT with mood disorders. In the CNS, 5-HT acts as a neurotransmitter in the dorsal raphe nucleus of the brain, Evidence-Based Complementary and Alternative Medicine with an important role in the regulation of cognitive, mood, behavioral, physiological, and neuroendocrine functions [17]. Depression is caused by insufficient 5-HT.…”

mentioning

confidence: 99%

Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression

Zhao

Tian

Song

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The current study aimed to investigate the effects and mechanisms of electroacupuncture (EA) treatment applied to Bai hui (GV20) and Yin tang (GV29) acupoints (1 mA, 2 Hz, continuous wave, 20 minutes) for 28 days in a rat model of chronic unpredictable mild stress (CUMS) on reuptake of serotonin (5-hydroxytryptamine (5-HT)) and miRNA-16 levels in the hippocampus and serum. Rats were housed in individual cages, and CUMS was used to establish a rat model of depression. After EA treatment for 4 weeks, behavioral changes and indices including 5-HT transporter (SERT), 5-HT, and miRNA-16 levels in the hippocampus and serum were examined. The EA treatment significantly improved base levels of sucrose preference and exploratory behavior and significantly decreased SERT protein and mRNA expression in the hippocampus of depressed rats. Significantly increased 5-HT levels were observed, and miRNA-16 levels were significantly decreased in the hippocampus and serum of depressed rats. In conclusion, the antidepressant effects of EA treatment may be affected via inhibition of 5-HT reuptake, upregulation of 5-HT levels, and inhibition of miRNA-16 expression in the hippocampus and serum.

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Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients

Cited by 33 publications

References 56 publications

Stress Enhances Proinflammatory Platelet Activity: the Impact of Acute and Chronic Mental Stress

Stress Enhances Proinflammatory Platelet Activity: the Impact of Acute and Chronic Mental Stress

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression

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