Platelet-rich therapies for musculoskeletal soft tissue injuries

Abstract

Platelet-rich therapies for musculoskeletal soft tissue injuries.

Unravelling confusion in sports medicine and sports science practice: a systematic approach to using the best of research and practice-based evidence to make a quality decision

“…The included SRs fulfilled a median 3 out of 11 AMSTAR items (range 110 11 to 1012) (table 2 and online supplementary table 1). All but one of the SRs were assessed as low quality and high or very high risk of bias (table 2).…”

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

“…Через 3, 6 и 12 мес стандартизированное отличие со-ставило 0,26 (95% ДИ 0,19-0,71; р=0,26), -0,09 (95% ДИ -0,56-0,39; р=0,72) и 0,25 (95% ДИ -0,07-0,57; р=0,12). Лишь в трех РКИ в первые 3 мес отмечалось достоверное (правда, небольшое) отличие от физиологического раство-ра по уровню снижения боли -в среднем на 0,95 см по 10-сантиметровой ВАШ [65].…”

Patterns of platelet rich plasma use among Australasian Sports Physicians

“…4 These permutations create a wide variability in the product and this creates uncertainty for researchers and clinicians as to what the optimal preparation method and formulation may be. 5 Commercial kits exist that appear to increase the consistency of this process, however, there is no evidence that the finished product is actually more consistent or effective than a simple centrifuge method using citrate tubes. 6 Furthermore, the injection of PRP may be performed with or without ultrasound guidance to confirm anatomical accuracy.…”

“…15 While PRP is probably not detrimental to healing, as corticosteroid injections are now thought to be, 16 most RCTs with a low risk of bias show lack of effectiveness for tendinopathy when compared with the normal saline placebo. 5 On the other hand, there is moderate evidence of small improvements in pain and function in early knee OA. 3 17 The pertinent RCTs are limited by their generally high risk of bias (mainly owing to a lack of blinding), with the highest quality studies comparing PRP to hyaluronic acid rather than placebo.…”