Platelet‐rich plasma versus platelet‐poor plasma in the management of chronic diabetic foot ulcers: a comparative study

Setta, Hany; Elshahat, Ahmed; El-Sherbiny, Khalid Mohamed; Massoud, Karim; Safe, Ikram

doi:10.1111/j.1742-481x.2011.00797.x

Cited by 126 publications

(129 citation statements)

References 18 publications

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“…PRP e HA sono terapie capaci di dare sollievo ai pazienti affetti da OA, e potenzialmente di ridurre, o per lo meno ritardare, il ricorso all'intervento chirurgico di artroprotesi al ginocchio (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Diversi studi mostrano che il PRP ha un'efficacia superiore all'HA (34)(35)(36)(37)(38)(39)(40)(41)(42).…”

Section: Discussioneunclassified

“…La provetta viene sottoposta a centrifugazione alla velocità di 1500 g (3400 rpm) per 5 minuti, il che consente di separare i globuli rossi (sotto il gel) dal plasma impoverito di piastrine (PPP) e il PRP (sopra il gel). Capovolgendo dolcemente e più volte la provetta BCT-1 si procede alla risospensione degli elementi cellulari nel surnatante e si ottiene il PRP (circa 4 ml), che può quindi essere prelevato mediante siringa sterile e infiltrato nell'articolazione del paziente (30,49).…”

Section: Costiunclassified

“…Diversi studi confermano l'efficacia clinica del PRP in differenti stadi della patologia OA (26)(27)(28)(29)(30)(31)(32)(33).…”

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Valutazione Economica Sull'utilizzo Del Plasma Arricchito di PiastrineVsAcido Ialuronico Per il Trattamento Dell'osteoartrosi al Ginocchio. Scenario a 1 Anno e a 5 Anni

Landi

Landa

Russo

2016

Global & Regional Health Technology Assessment

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ORIGINAL RESEARCH ARTICLErischio, tra i quali il genere (le donne sono più predisposte), l'età, il tipo di attività lavorativa, l'obesità (1-3).Le patologie muscoloscheletriche sono l'ottava causa a livello mondiale, e la quarta nei Paesi occidentali, per anni di vita persi per disabilità (disability-adjusted life-year, DALY). Almeno la metà delle patologie muscoloscheletriche sono attribuibili all'osteoartrosi (4) ed essa risulta essere l'undicesima patologia per peso di contribuzione alla disabilità a livello mondiale su 291 patologie, e trentottesima per DALY (5).Il carico medico e sociale dell'OA determina un forte impatto economico sui sistemi sanitari (6, 7), in particolare nei Paesi occidentali dove l'incidenza è più elevata. I costi sanitari diretti sono dovuti ai farmaci utilizzati per ridurre il dolore e la limitazione funzionale, esami medici, ricoveri e interventi chirurgici di sostituzione dell'articolazione danneggiata (artroprotesi). The increasing incidence of total joint arthroplasty reflects the rises of osteoarthritis (OA) prevalence. OA is a degenerative pathology affecting joints with a significant impact on quality of life causing pain, leading to social life limitations and loss of work productivity. According to the World Health Organization, OA is one of the most important causes of people's disability. The burden of the disease is correlated with a huge economic impact on the health care systems. Intra-articular infiltration therapies are used between the pharmacological and the surgical phases, in order to delay surgery. This work aims to carry out an economic evaluation on the use of the Platelet-RichPlasma (PRP) therapy in the treatment of knee OA. The comparator is the hyaluronic acid, i.e. the standard therapy for drug-resistant OA that does not benefit or has short term benefits (<1 month) with intra-articular corticosteroids. Methods: A cost-effectiveness analysis has been performed using a decision-analytic model considering two scenarios: short period and medium period. The effectiveness outcomes are reported in term of quality-adjusted life-years (QALYs), while costs are expressed in euro (€). The adopted perspective is the Italian National Health System (INHS). The results are shown through the incremental cost-effectiveness ratio (ICER) examining the PRP versus the comparator. Moreover, deterministic and probabilistic sensitivity analyses have been performed to test the robustness of the results. Results: The PRP therapy, for patients with moderate to severe knee OA in the Italian context, is cost-effective versus HA with ICERs of €1,524/QALY in the 1 year and €162/QALY in the 5 year scenarios. Conclusions: In the short term, it seems that the PRP therapy is cost-effective in the treatment of knee OA versus the HA therapy. However, more research is needed to assess its cost-effectiveness in the long term and to figure out if this treatment may be an efficient resource allocation for the INHS.

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Section: Discussioneunclassified

Section: Costiunclassified

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Valutazione Economica Sull'utilizzo Del Plasma Arricchito di PiastrineVsAcido Ialuronico Per il Trattamento Dell'osteoartrosi al Ginocchio. Scenario a 1 Anno e a 5 Anni

Landi

Landa

Russo

2016

Global & Regional Health Technology Assessment

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“…Although the efficacy of PRP has been investigated in wound healing [12][13][14][15] , its effects on TMP healing have not yet been investigated in acute TMPs. In the literature, the only study on the effect of PRP on TMP closure is that reported by El-Anwar et al [16] , wherein they studied 64 patients with chronic TMPs who had undergone postauricular myringoplasty with underlay graft using conchal perichondrial graft.…”

Section: Discussionmentioning

confidence: 99%

“…There have been human studies to report that PRP has a positive effect on wound healing [12][13][14][15] . In animal studies, histological examinations revealed enhanced fibroblastic and endothelial cell formation during wound healing, increased neovascularization [12,[19][20][21][22] , and enhanced granulation tissue formation [12,19,21,22] .…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Özgürsoy

Tunçkaşık²,

Tunçkaşık³

et al. 2017

Int Adv Otol

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OBJECTIVE:To assess the efficacy of the application of platelet-rich plasma (PRP) in the healing process of acute tympanic membrane perforations (TMPs). MATERIALS and METHODS:Acute TMPs were made in both the ears of 12 New Zealand rabbits. Plasma gel was applied at the right tympanic membrane (TM) of the same animal until the perforations were closed. The left TM was left untreated. On days 1, 4, 7, 10, 13, 16, 21, 28, and 35, the TMs were monitored to check the closure of perforations. The days of perforation closure for the 2 groups were compared using the paired t-test. The animals were sacrificed 2 months after making the perforations. Seven histopathological parameters were reviewed by 2 blinded pathologists: acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, sclerosis, fibroblastic reaction, and an increase in the thickness of the squamous epithelial layer. The presence or absence of each histological parameter in both groups was compared using the Pearson Chi-square test. RESULTS:The average number of days for closure in the plasma gel group was 12 (range 8-18 days) and that in the control group was 17.7 (range 8-31 days). The difference was statistically significant (p=0.0145). There was no sclerosis or fibroblastic reaction in any of the specimens. No statistically significant difference was seen between the 2 groups with respect to acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, and an increase in thickness of the squamous epithelial layer (p>0.05). CONCLUSION:Platelet-rich plasma fastens TMP closure; in long term, the eventual outcome is both microscopically and macroscopically same for the control as well as study groups in a rabbit traumatic TMP model. We believe that this study will encourage the clinical use of PRP for acute TMPs and trigger clinical studies in this field.

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