“…In a prospective study, PRP for the treatment of 94 shaft fracture non-unions (35 of the tibia, 30 of the femur, 11 of the humerus, four of the radius, 12 of the ulna, two involving both radius and ulna) resulted in an 87% rate of union at 4 months [74]. In a randomized controlled trial, PRP injections were compared with exchange nailing after IMN, for the treatment of 29 diaphyseal oligotrophic non-unions of tibia and femur, showing superior healing rate in the PRP group compared with exchange nailing group (93% vs. 80%) [75]. Despite early promising results, at the moment, the grades of recommendation for PRP use in bone healing indicates conflicting or poor-quality evidence, and therefore, further investigation is needed [76].…”