Platelet-Rich Plasma Therapy in the Treatment of Recalcitrant Melasma

Garg, Shilpa; Khillan, Kamini; Bharija, Subhash Chandra

doi:10.1097/00042728-900000000-98704

Cited by 3 publications

(5 citation statements)

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“…The regression of melasma with PRP therapy has been reported by Garg and colleagues 4 where 2 patients of melasma underwent PRP therapy. The MASI score was 64 in the first patient and 47 in the second patient before starting PRP therapy.…”

Section: Discussionmentioning

confidence: 57%

“…2 Platelet-rich plasma (PRP) therapy has been reported to be beneficial in the treatment of chronic wounds, acne scars, alopecia, and photoageing and has shown its efficacy in the management of melasma. 3,4 In melasma, a high concentration of autologous platelets is prepared in a small volume of plasma and is delivered intradermally using microinjections. 5 However, there is paucity of studies on the use of PRP in melasma in a large sample size.…”

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confidence: 99%

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Role of Platelet-Rich Plasma Therapy as an Adjuvant in Treatment of Melasma

Bikash

Sarkar

Relhan

et al. 2022

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BACKGROUND The management of melasma is an ongoing challenge. Platelet-rich plasma (PRP) therapy has been reported to be beneficial, but there is paucity of studies on PRP therapy in melasma. OBJECTIVE To compare the efficacy of PRP therapy and hydroquinone versus hydroquinone alone in melasma. MATERIALS AND METHODS Thirty patients were randomized to receive PRP microinjections on one side and normal saline on the other in a total of 3 sittings. Patients were concurrently advised 4% hydroquinone (HQ) cream application on both sides of the face. Efficacy was evaluated with hemi-modified Melasma Area Severity Index (MASI) scoring and a 4scale patient satisfaction grading. RESULTS Majority of the subjects (53.3%) in PRP + HQ group and 76.7% in HQ group had 25% to 50% improvement in their MASI scores. However, 40% in the PRP + HQ group and only 3.3% in the HQ group had 51% to 75% improvement. The difference in the percentage improvement was statistically significant. There was a greater percentage of subjects reporting a good response among the HQ + PRP group (53.3%) as compared with the HQ group (27%). CONCLUSION Microinjections of PRP combined with topical HQ has better efficacy than topical HQ alone.

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Section: Discussionmentioning

confidence: 57%

mentioning

confidence: 99%

Role of Platelet-Rich Plasma Therapy as an Adjuvant in Treatment of Melasma

Bikash

Sarkar

Relhan

et al. 2022

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“…4 However, its use has not been standardized, given that few studies have been conducted on patients with melasma, and none of them on a Latin American population. 18,20,21 PRP seems to be a promising therapeutic modality for melasma with the unveiling of its mechanisms and clinical efficacy demonstrated in different diseases regarding skin regeneration. We aim to investigate the clinical effectiveness of PRP administrated for the treatment of melasma.…”

Section: Introductionmentioning

confidence: 99%

“…Current evidence on PRP and melasma treatment showed fewer side effects and less rebound hyperpigmentation than other melasma treatments 4 . However, its use has not been standardized, given that few studies have been conducted on patients with melasma, and none of them on a Latin American population 18,20,21 …”

Section: Introductionmentioning

confidence: 99%

Treatment of melasma with platelet‐rich plasma: A self‐controlled clinical trial

Ojeda

Guevara

Chejfec-Ciociano

et al. 2022

Dermatologic Therapy

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Melasma is a common circumscribed hypermelanosis of sun-exposed areas of the skin. Platelet-Rich Plasma therapy has been evidenced to inhibit melanin synthesis in animals and humans. To determine the effectiveness of platelet-rich plasma as a treatment for melasma. Twenty female patient with melasma were involved in this study. The intervention included three Platelet-Rich Plasma application sessions at 15-day intervals. Patients were evaluated before and after treatment. Variables measured included the facial melanin concentration using the melasma area and severity index score, melasma quality of life scale satisfaction grade, and histologic changes.Mean age was 41 ± 7 years. An initial MELASQOL score of 42 ± 14.8 and final score of 16.6 ± 7.2 (p = 0.008) were reported; the initial and final MASI score were 15.5 ± 8.4 and 9.5 ± 7.2 (p = 0.001), respectively. The dermatoscopy examination revealed a decrease in pigmentation after intervention (p = 0.001). Histopathologic improvement was detected in reductions in cutaneous atrophy (14 [70%] vs. 11 [55%]), solar elastosis (15 [75%] vs.11 [55%]), and inflammatory infiltrate

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“…5 In the study by Garg et al, it was found that intralesional injection of PRP in patients with melasma, which was resistant to oral and topical therapy along with chemical peels, brought significant relief with almost 50% reduction in their MASI score. 6 Darker skin types are difficult to treat compared to lighter types.…”

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confidence: 99%