Platelet-rich plasma stimulates osteoblastic differentiation in the presence of BMPs

Effect of BMP2–Platelet-rich Plasma–Biphasic Calcium Phosphate Scaffold on Accelerated Osteogenesis in Mastoid Obliteration

“…Many synthetic bone scaffolds have been used as bone substitutes in mastoid obliteration. Regarding the acceleration of bone formation on BCP ceramics, both HA and TCP are well known for functioning as carriers of BMP2 (18). Previous studies have shown that the incorporation of BMP2 into bone scaffolds accelerates bone formation in mastoid obliteration (10,11).…”

“…As PRP stimulates osteoblastic differentiation in the presence of BMPs (18), it is assumed that PRP and BMP2 can act synergistically to enhance osteogenesis of alloplastic scaffold. However, to date, only three studies have demonstrated the efficacy of PRP along with BMP2 in bone regeneration (19)(20)(21).…”

Glucosamine-chondroitin sulphate accelerates tendon-to-bone healing in rabbits

“…[8][9][10][11][12][13][14] Still, in addition to the physiological difficulties, which may be experienced in the healing process, implementation materials may also affect the recovery phase negatively. Tsukada et al [28] histologically and biomechanically investigated the effect of the remaining sutures placed on the tendon in the tunnel by a study conducted on 60 rabbits.…”

“…[8][9][10] Recently, platelet rich plasma has gained popularity, affecting healing by increasing tenocyte proliferation and stimulating collagen production. [11,12] Using growth factors with coverage of tendon with the periosteum as a shield have been also used to improve healing. [13,14] In contrast to platelet rich plasma, a topical hemostatic agent (Ankaferd Blood Stopper ® ; Ankaferd Ilac Kozmetik AS, Istanbul, Turkey) was shown to negatively affect tendon healing.…”

Adipose-derived stem cells and platelet-rich plasma for preventive treatment of bisphosphonate-related osteonecrosis of the jaw in a murine model

“…In group 4, ASCs cultured with BMP-2 were directly spread over alveolar sockets and covered with a PRP clot, which might have less direct influence over the ASCs. In order to enhance the osteogenic capacities of the ASCs, we introduced BMP-2, as this protein has been reported to be an osteogenic enhancer (Cowan et al, 2005) and PRP has been described as an enhancer of osteoblastic differentiation in the presence of BMPs (Tomoyasu et al, 2007). With this combination, we achieved the lowest incidence of BRONJ.…”