Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach

Filardo, Giuseppe; Kon, Elizaveta; Ruiz, Maria Teresa Pereira; Vaccaro, Franca; Guitaldi, Rita; Martino, Alessandro Di; Cenacchi, Annarita; Fornasari, Pier Maria; Marcacci, Maurilio

doi:10.1007/s00167-011-1837-x

“…No major complication such as deep infection, muscle atrophy, deep vein thrombosis, fever, hematoma, tissue hypertrophy, adhesion formation, or other major adverse events occurred among study subjects. Similar studies by Sampson S et al [6] , Filardo G et al [7] , Kon E et al [5] , Sun Y et al [8] and Giannini S et al [9] showed no major complication or adverse effects. In our study, three cases in GFRP group showed temporary worsening of pain for about 24 hours which resolved spontaneously.…”

Section: Discussionsupporting

confidence: 80%

Comparative study of static versus dynamic intramedullary nailing of tibia

Somani¹,

Saji²,

Rabari³

et al. 2017

Int. J. Orthop. Sci.

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Worldwide osteoarthritis is the most common joint disorder. It results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix and subchondral bone. These changes include increased water content, decreased proteoglycan content and altered collagen matrix, leading to the degeneration of articular cartilage. There is trend on rise to use platelet rich plasma to promote healing of the degenerated cartilage. The aim of the study was to evaluate whether the newer method i.e platelet rich plasma has any significant advantage. The study included a total of 50 cases with individuals ageing greater than 40 years. Patients without evidence of degenerative arthritis and with KL grade 3 and grade 4 were excluded from the study. At 1 month only 14% cases showed excellent, 68% cases showed and. 18% cases showed fair results. At 3 months follow up 16% cases showed excellent, 82% cases showed good and fair results were seen in 2% cases. No case had poor results. At 6 months follow up 16% cases showed excellent, 86% cases showed good and 6% cases showed fair results and no case had poor results. Platlet rich plasma is an excellent method of treatment in early osteoarthritis of knee.

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“…No major complication such as deep infection, muscle atrophy, deep vein thrombosis, fever, hematoma, tissue hypertrophy, adhesion formation, or other major adverse events occurred among study subjects. Similar studies by Sampson S et al [6] , Filardo G et al [7] , Kon E et al [5] , Sun Y et al [8] and Giannini S et al [9] showed no major complication or adverse effects. In our study, three cases in GFRP group showed temporary worsening of pain for about 24 hours which resolved spontaneously.…”

Section: Discussionsupporting

confidence: 72%

Functional outcome of surgical management of floating knee injuries in adults (Ipsilateral femoral and tibia fractures) and its prognostic indicators

Hp¹,

Kamran²,

Lingaraju³

et al. 2017

Int. J. Orthop. Sci.

2

0

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Worldwide osteoarthritis is the most common joint disorder. It results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix and subchondral bone. These changes include increased water content, decreased proteoglycan content and altered collagen matrix, leading to the degeneration of articular cartilage. There is trend on rise to use platelet rich plasma to promote healing of the degenerated cartilage. The aim of the study was to evaluate whether the newer method i.e platelet rich plasma has any significant advantage. The study included a total of 50 cases with individuals ageing greater than 40 years. Patients without evidence of degenerative arthritis and with KL grade 3 and grade 4 were excluded from the study. At 1 month only 14% cases showed excellent, 68% cases showed and. 18% cases showed fair results. At 3 months follow up 16% cases showed excellent, 82% cases showed good and fair results were seen in 2% cases. No case had poor results. At 6 months follow up 16% cases showed excellent, 86% cases showed good and 6% cases showed fair results and no case had poor results. Platlet rich plasma is an excellent method of treatment in early osteoarthritis of knee.

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“…30 Both studies showed no significant changes between groups. These studies emphasize the fact that current literature is lacking randomized controlled studies aimed to introduce the optimal PRP treatment (preparation characteristics, administration protocol, etc.)…”

Section: Discussionmentioning

confidence: 88%

“…These included local pain, stiffness, syncope, dizziness, headache, nausea, sweating, and tachycardia, all self-limited. Filardo et al 30 reported temporary pain and swelling reaction for the PRP treatment (number of patients not mentioned). Spakova et al 32 documented temporary mild worsening of pain in the knee joint after application of PRP in 6 cases (out of 60), which was spontaneously resolved after 2 days.…”

Section: Adverse Effectsmentioning

confidence: 99%

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

Laver

¹

,

Marom

²

,

Lad

³

et al. 2016

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Objective: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. Design: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis." Results: The final result yielded 29 articles. Twenty-six studies examined PRP administration for knee OA and 3 involved PRP administration for hip OA. The results included 9 prospective randomized controlled trials (RCTs) (8 knee and 1 hip), 4 prospective comparative studies, 14 case series, and 2 retrospective comparative studies. Hyaluronic acid (HA) was used as a control in 11 studies (7 RCTs, 2 prospective comparative studies, and 2 retrospective cohort). Overall, all RCTs reported on improved symptoms compared to baseline scores. Only 2 RCTs-one for knee and one for hip-did not report significant superiority of PRP compared to the control group (HA). Nine out of 11 HA controlled studies showed significant better results in the PRP groups. A trend toward better results for PRP injections in patients with early knee OA and young age was observed; however, lack of uniformity was evident in terms of indications, inclusion criteria, and pathology definitions in the different studies. Conclusion: Current clinical evidence supports the benefit in PRP treatment for knee and hip OA, proven to temporarily relieve pain and improve function of the involved joint with superior results compared with several alternative treatments. Further research to establish the optimal preparation protocol and characteristics of PRP injections for OA is needed.

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Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach

Abstract: II.

Cited by 354 publications

References 35 publications

Comparative study of static versus dynamic intramedullary nailing of tibia

Comparative study of static versus dynamic intramedullary nailing of tibia

Functional outcome of surgical management of floating knee injuries in adults (Ipsilateral femoral and tibia fractures) and its prognostic indicators

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

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