Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study

Moretti, Luigi; Maccagnano, Giuseppe; Coviello, Michele; Cassano, Giuseppe Danilo; Franchini, Andrea; Laneve, Andrea; Moretti, Biagio

doi:10.3390/jcm11092640

Cited by 27 publications

(13 citation statements)

References 26 publications

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“…The effects of PRP on pain reduction have been previously observed in other studies and several authors have reported the analgesic properties of platelets [ 44 , 45 ]. Postoperative pain was mainly induced by inflammation [ 46 ].…”

Section: Discussionmentioning

confidence: 63%

Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

Feng

2022

J Orthop Surg Res

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Background There is conflicting clinical evidence whether platelet-rich plasma (PRP) therapies could translate to an increased meniscus healing rate and improved functional outcomes. The objective of this systematic review and meta-analysis was to compare the failure rate and patient-reported functional outcomes in meniscus repair augmented with and without PRP. Methods We comprehensively searched the PubMed, Web of Science, Medline, Embase, and Cochrane Library databases to identify studies that compared the clinical efficacy of meniscus repair performed with PRP versus without PRP. The primary outcome was the meniscus repair failure rate, while the secondary outcomes were knee-specific patient-reported outcomes, including the International Knee Documentation Committee (IKDC) score, Lysholm knee scale, visual analog scale, Tegner activity level score, Western Ontario and McMaster Universities Osteoarthritis Index score, Single Assessment Numeric Evaluation score, and Knee injury and Osteoarthritis Outcome Score. Furthermore, subgroup analyses were performed by stratifying the studies according to the PRP preparation technique to investigate the potential sources of heterogeneity among studies. Results Our meta-analysis included nine studies (two RCTs and seven non-RCTs) with 1164 participants. The failure rate in the PRP group was significantly lower than that in the non-PRP group [odds ratio: 0.64, 95% confidence interval (CI) (0.42, 0.96), P = 0.03]. Furthermore, the PRP group was associated with a statistically significant improvement in the visual analog scale for pain [Mean difference (MD): − 0.76, 95% CI (− 1.32, − 0.21), P = 0.007] and Knee injury and Osteoarthritis Outcome Score-symptom [MD: 8.02, 95% CI (2.99, 13.05), P = 0.002] compared with the non-PRP group. However, neither the IKDC score nor the Lysholm knee scale showed any differences between the two groups. In addition, the results of subgroup analyses favored PRP over platelet-rich fibrin matrix (PRFM) regarding the IKDC score. Conclusions Although meniscus repairs augmented with PRP led to significantly lower failure rates and better postoperative pain control compared with those of the non-PRP group, there is insufficient RCT evidence to support PRP augmentation of meniscus repair improving functional outcomes. Moreover, PRP could be recommended in meniscus repair augmentation compared with PRFM. PRFM was shown to have no benefit in improving functional outcomes.

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Section: Discussionmentioning

confidence: 63%

Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

Feng

2022

J Orthop Surg Res

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“…Another significant clinical trial carried out by Moretti. L et al concluded that although there was noteworthy pain reduction in people who were diagnosed with KOA, there were no radiographic changes reflected (39). Recent studies have also indicated an increased efficacy of PRP in Ahlba ck grades I and II as compared to more severe OA (40).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effectiveness of Intra-articular Platelet Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Systematic Review

Joanna,

Devpal Patil,

Wessam

et al. 2023

SVOAOR

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Introduction: Osteoarthritis (OA) is the most frequently presented joint disorder, and its treatment is often challenging. Current literature has controversial results regarding the efficacy of Platelet Rich Plasma therapy (PRP) when compared to placebo injections. This systematic review investigates the role of intra-articular PRP injections as a recommended treatment option for knee OA with the potential to establish appropriate guidelines for treating physicians. Method: This review used PUBMED, Cochrane and CINHAL database. A thorough review of literature examining PRP injections as treatment options for knee OA was performed. Two independent reviewers evaluated the studies against inclusion and exclusion criterias. The WOMAC stiffness score, VAS Score, and KOOS score were used to assess efficacy of PRP treatment. Twelve articles met the criteria for inclusion and were analysed in this study. Results: PRP injections caused a significantly better improvement in WOMAC stiffness score (25.5%), VAS Score (31.7%), and KOOS score (6.2%) after six months of treatment. Conclusion: This review demonstrated significant improvement in pain relief and stiffness levels in patients with knee OA receiving intra-articular PPR when compared to placebo. Further research is required to establish the optimum dose and duration of treatment with PRP injections for knee OA.

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“…PDGF plays a crucial role in cell proliferation and angiogenesis, while TGF-β is renowned for its involvement in cell differentiation and the synthesis of extracellular matrix components. Conversely, IGF exerts potent effects on cellular metabolism and tissue development [ 7 ]. The synergistic action of these growth factors is fundamental to the therapeutic mechanisms of PRP.…”

Section: Reviewmentioning

confidence: 99%

Navigating the Therapeutic Landscape: A Comprehensive Review of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate in Knee Osteoarthritis

Balusani,

Shrivastava,

Pundkar

et al. 2024

Cureus

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This comprehensive review provides an in-depth analysis of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) as potential treatments for knee osteoarthritis. It explores their mechanisms of action, clinical efficacy, safety considerations, and the importance of personalised treatment approaches. The review highlights promising findings regarding the ability of PRP and BMAC to alleviate symptoms, improve joint function, and potentially slow disease progression. It emphasises the need for further research into long-term outcomes, direct comparative studies, protocol standardisation, biomarker identification, and cost-effectiveness assessments to enhance clinical practice. While the review does not directly compare PRP and BMAC, it provides valuable insights into their respective roles in knee osteoarthritis management. The review aims to contribute to evidence-based advancements in regenerative therapies for knee osteoarthritis by addressing critical research priorities and refining treatment strategies.

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Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study

Cited by 27 publications

References 26 publications

Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

Evaluating the Effectiveness of Intra-articular Platelet Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Systematic Review

Navigating the Therapeutic Landscape: A Comprehensive Review of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate in Knee Osteoarthritis

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