Platelet-rich plasma in treatment of patients with idiopathic carpal tunnel syndrome

Senna, Mohammad K; Shaat, Reham M.; Ali, Alaa Ali Awad

doi:10.1007/s10067-019-04719-7

Cited by 44 publications

(98 citation statements)

References 33 publications

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“…Of the ten included studies, three compared PRP with corticosteroid injection [27,30,32], one compared PRP with saline injection [28], three compared PRP injection (with or without additional splinting) with splinting alone [23,29,33], one [34] compared D5W with saline injection, one [22] compared D5W with corticosteroid injection, and one [31] compared PRP with D5W injection. With respect to outcome assessment, the Boston Carpal Tunnel Questionnaire (BCTS) was used in nine [22,23,27,[29][30][31][32][33][34] of the ten enrolled studies. The visual analogue scale (VAS) for pain was used as a surrogate for the symptom severity scale (SSS) in one trial [28].…”

Section: Introductionmentioning

confidence: 99%

“…The visual analogue scale (VAS) for pain was used as a surrogate for the symptom severity scale (SSS) in one trial [28]. In terms of the injection technique, seven studies [22,23,28,30,31,33,34] used ultrasound guidance, whereas three [27,29,32] employed palpation guidance. The maximal follow-up duration was 24 weeks in five trials [22,[31][32][33][34], 12 weeks in three trials [27,28,30], 10 weeks in one trial [29], and four weeks in one trial [23].…”

Section: Introductionmentioning

confidence: 99%

“…Three studies were further discarded because one was a conference proceeding without retrievable data [24], one was a case report [25], and the other was a case series without a control group [26]. Therefore, ten studies were included in the final quantitative analysis (Figure 1) [22,23,[27][28][29][30][31][32][33][34].…”

mentioning

confidence: 99%

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Regenerative Injections Including 5% Dextrose and Platelet-Rich Plasma for the Treatment of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis

et al. 2020

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This network meta-analysis aimed to integrate the available direct and indirect evidence on regenerative injections-including 5% dextrose (D5W) and platelet-rich plasma (PRP)-for the treatment of carpal tunnel syndrome (CTS). Literature reports comparing D5W and PRP injections with non-surgical managements of CTS were systematically reviewed. The main outcome was the standardized mean difference (SMD) of the symptom severity and functional status scales of the Boston Carpal Tunnel Syndrome Questionnaire at three months after injections. Ranking probabilities of the SMD of each treatment were acquired by using simulation. Ten studies with 497 patients and comparing five treatments (D5W, PRP, splinting, corticosteroid, and normal saline) were included. The results of the simulation of rank probabilities showed that D5W injection was likely to be the best treatment, followed by PRP injection, in terms of clinical effectiveness in providing symptom relief. With respect to functional improvement, splinting ranked higher than PRP and D5W injections. Lastly, corticosteroid and saline injections were consistently ranked fourth and fifth in terms of therapeutic effects on symptom severity and functional status. D5W and PRP injections are more effective than splinting and corticosteroid or saline injection for relieving the symptoms of CTS. Compared with splinting, D5W and PRP injections do not provide better functional recovery. More studies investigating the long-term effectiveness of regenerative injections in CTS are needed in the future.Pharmaceuticals 2020, 13, 49 2 of 17 factors of CTS include, but are not limited to, female sex, obesity, diabetes, and hypothyroidism [4,5]. The diagnosis of CTS is traditionally based on electrophysiological tests; however, ultrasonographic nerve cross-sectional area measurements have also recently emerged as useful alternatives [6]. The therapeutic algorism for CTS can be based on symptom severity, findings of electrophysiological tests, and responsiveness to non-surgical therapy. Conservative treatments for mild to moderate CTS include corticosteroid injection [7], splinting [8], and physiotherapy (like therapeutic ultrasound, exercise, and neural mobilization) [9,10]. In patients with moderate to severe symptoms and poor responsiveness to non-operative management, carpal tunnel release (CTR) is indicated [11]. However, the symptoms might persist in 3% to 20% of patients after CTR [12]. In recalcitrant cases, the physicians should consider surgical management, such as revision neuroplasty, neurolysis, and nerve reconstruction [12].Corticosteroids function as potent anti-inflammatory medications and have been widely used as the main injectate for treating CTS. A recent randomized controlled trial that recruited 234 patients with CTS demonstrated that a single corticosteroid injection was better than night splinting in terms of clinical effectiveness at six weeks post-injection [13]. The aforementioned result is consistent with that of a previous systematic review that revealed the s...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regenerative Injections Including 5% Dextrose and Platelet-Rich Plasma for the Treatment of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis

et al. 2020

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“…Esta mejora se midió utilizando el CTCB y se observaron reducciones significativas en múltiples estudios de gravedad de los síntomas. Sin embargo, este hallazgo no fue unánime y, en algunos casos, no proporcionó un beneficio mayor cuando se agregó a un plan de tratamiento que incluía una férula para muñeca conservadora (12). Dada la escasez de literatura publicada actualmente sobre este tema, existe la posibilidad de seguir estudiando las inyecciones de PRP para el tratamiento del STC.…”

Section: Discussionunclassified

“…Alternativamente, las inyecciones de plasma rico en plaquetas (PRP) contienen plaquetas concentradas y varios factores de crecimiento que pueden ayudar a aliviar los síntomas. Los mecanismos incluyen crecimiento, angiogénesis y regeneración de axones que podrían promover la regeneración del nervio mediano (12). La PRP ha demostrado su eficacia en una variedad de aplicaciones, desde odontología hasta ortopedia y desde neurocirugía hasta cosméticos (13).…”

Section: Plasma Rico En Plaquetasunclassified

Tratamiento del síndrome del túnel del carpo

Contreras¹,

Salazar²,

Alvarado³

et al. 2020

jah

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Esta revisión narrativa analiza la literatura para determinar los conceptos actuales sobre el tratamiento de síndrome del túnel carpiano que permitan actualizar los conocimientos al personal sanitario. Se utilizó repositorios digitales como Pubmed, Elsevier y SCIELO para la búsqueda avanzada de la bibliografía sobre el tema, usando las palabras clave específicas “túnel carpiano”, “tratamiento”, “parestesias” y “electromiografía”. Se analizaron artículos con menos de cinco años de publicación que resultaron de la búsqueda avanzada de la información. Conclusión: Esta revisión aclara algunos aspectos sobre el tratamiento de esta enfermedad. Las opciones de tratamiento conservador incluyen inmovilizar la muñeca en una posición neutral y fisioterapia. Los corticosteroides orales pueden ser efectivos a corto plazo (dos a cuatro semanas), pero las inyecciones locales pueden mejorar los síntomas durante un período más prolongado. Si los síntomas son refractarios a las medidas conservadoras o si los estudios de conducción nerviosa muestran un atrapamiento severo, puede ser necesaria la liberación abierta o endoscópico del túnel carpiano.

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Regenerative Medicine for Trigeminal Nerve Pain

Patel

Chien

2020

Trigeminal Nerve Pain

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Platelet-rich plasma in treatment of patients with idiopathic carpal tunnel syndrome

Cited by 44 publications

References 33 publications

Regenerative Injections Including 5% Dextrose and Platelet-Rich Plasma for the Treatment of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis

Regenerative Injections Including 5% Dextrose and Platelet-Rich Plasma for the Treatment of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis

Tratamiento del síndrome del túnel del carpo

Regenerative Medicine for Trigeminal Nerve Pain

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