Platelet-Rich Plasma in the Management of Chronic Endometritis Treatment in Women with Reproductive Health Disorders

Abstract

Background: Chronic endometritis (CE) is one of aggressive factor of infertility and reproductive losses.
 Objective: We aimed to assess the effectiveness of using platelet-rich plasma (PRP) treatment of chronic endometritis (CE) treatment in women with infertility (PI) and recurrent pregnancy losses (RPL).
 Material and methods: In this non-randomized clinical trial, women aged 22-45 years with CE diagnosed by positive CD 138 between February 2017 and December 2019 were included. Were investigated 65 women - 30 patients with RPL and 35 women with PI and unsuccessful attempts at IVF. PRP therapy was performed paracervical ( 6 ml) and intrauterus ( 1,5 ml) once a week for 4 -8 weeks. Control of the treatment of CE was performed by endometrial biopsy pipelines 15-20 days after the last PRP.
 Results: After carrying out 4 procedures of combined paracervical and intrauterine PRP, CE was cured in 70-77% of women (p <0.05); after 8 procedures - 97% (p <0.01).
 Conclusions: Combined intrauterine and paracervical PRP therapy is an effective treatment for CE in women with PI and RPL.