“…20 Methods of the PRP application include topical application after the use of any microneedling instrument, 5 as used in this study, as well as direct injection into the dermis, which is more invasive and may give similar outcomes to that obtained by topical application. 21 Aging of the skin is a multifactorial phenomenon in which ongoing intrinsic changes combine the cumulative effects of chronic exposure to the elements, primarily ultraviolet radiation (UVR), in a synergistic fashion, resulting in loss of skin thickness and elasticity and appearance of wrinkles. 2 Meanwhile, facial aging is the result of both superficial textural wrinkling of the skin with changes in the 3-dimensional (3-D) topography of the underlying structures.…”