Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis

Katz, Jeffrey N.

doi:10.1001/jama.2021.19540

Cited by 19 publications

(11 citation statements)

References 23 publications

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“…27 These substances have protean anabolic properties, including the capacity to remodel bone and blood vessels and promote angiogenesis, chondrogenesis, and collagen synthesis. 20 In 2015, Andia et al 2 concluded that PRP injections in pathological and nearby tissue can help in recovering tendon homeostasis.…”

mentioning

confidence: 99%

Update on the Use of Platelet-Rich Plasma Injections in the Management of Musculoskeletal Injuries: A Systematic Review of Studies From 2014 to 2021

O’Dowd

2022

Orthopaedic Journal of Sports Medicine

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Background: There has been expanding use of platelet-rich plasma (PRP) in the management of musculoskeletal soft tissue injuries. Purpose: To determine if there are any recent studies that show any clear benefits regarding the use of PRP in the management of soft tissue injuries. Study Design: Systematic review. Methods: This review was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The EMBASE, MEDLINE, PubMed, and Cochrane Bone, Joint and Muscle Group Specialised Register databases were queried for randomized controlled trials comparing PRP with a non-PRP/placebo in participants >18 years of age with musculoskeletal soft tissue injuries. Exclusion criteria were non–soft tissue injuries and research published in journals with an impact factor <3.5. The main outcome measure analyzed across all injury types was the effect of PRP injections on pain and function. Results: Of the 853 studies initially screened, 32 were included in this review. There were 13 studies that investigated the effects of PRP on the management of rotator cuff injuries; 7 studies that investigated PRP in conjunction with arthroscopy found no significant difference between PRP groups and controls, while 5 of 6 studies that investigated nonsurgical management showed positive results for PRP. Eight studies investigated various tendinopathies; of these, 2 studies demonstrated positive results for PRP in Achilles and gluteal tendinopathy management. Six studies examined PRP in acute soft tissue injuries, with 2 of these reporting significant improvements in recovery time for hamstring injuries and 1 study showing positive results for ankle ligament injuries. Two studies looked at acute rupture of soft tissues and found no benefit to PRP use. Two studies investigated PRP injections for chronic plantar fasciitis, and both reported positive results in pain and function with PRP. Finally, 1 study evaluated the effects of PRP on meniscal injuries and reported significant improvement in the healing rate and a decreased need for surgical repair. Conclusion: Currently, there is no research strongly advocating the use of PRP compared with traditional management strategies (rest, ice, corticosteroid injection, rehabilitation program). No long-term physiological benefits were reported to justify the invasive and costly technique of obtaining, producing, and implementing PRP.

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confidence: 99%

Update on the Use of Platelet-Rich Plasma Injections in the Management of Musculoskeletal Injuries: A Systematic Review of Studies From 2014 to 2021

O’Dowd

2022

Orthopaedic Journal of Sports Medicine

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“…Regenerative therapy has emerged as one of the most recent and rapidly evolving strategies for treating OA. 511 , 512 Platelet-rich plasma extracted from blood samples provides important growth factors which may facilitate OA recovery. 511 – 513 Platelet-rich plasma led to clinical improvements 12 months after injection and completed the phase 4 clinical trial (NCT02984228) in Aug. 2022.…”

Section: Clinical Therapy and Clinical Trialsmentioning

confidence: 99%

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Yao

Tao

et al. 2023

Sig Transduct Target Ther

319

147

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Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues, which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction. Currently, there is no cure for OA, partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease. Therefore, a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development. In this review, we first summarize the epidemiology of OA, including its prevalence, incidence and burdens, and OA risk factors. We then focus on the roles and regulation of the pathological signaling pathways, such as Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/ΒΜP and FGF signaling pathways, and key regulators AMPK, mTOR, and RUNX2 in the onset and development of OA. In addition, the roles of factors associated with OA, including MMPs, ADAMTS/ADAMs, and PRG4, are discussed in detail. Finally, we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA. Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies.

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“…1,2 Recognizing PRP's ostensible osteoinductive prowess, particularly in bolstering osteoblast proliferation and enhancing matrix formation, its adoption across diverse medical disciplines, and more notably in orthopedics, has experienced an appreciable surg. [3][4][5][6] The autologous derivation of PRP offers both economic advantages and obviates potential immunogenic complications commonly linked to exogenous recombinant growth factors. Such benefits not only mitigate the risk of disease transmission but also facilitate its application in surgical contexts.…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma in orthopedics: Bridging innovation and clinical applications for bone repair

Zhu,

Li,

Qin

et al. 2024

J Orthop Surg (Hong Kong)

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In the burgeoning domain of orthopedic therapeutic research, Platelet-Rich Plasma (PRP) has firmly established its position, transforming paradigms ranging from tissue regeneration to the management of chondral lesions. This review delves into PRP’s recent integrations with cutting-edge interventions such as 3D-printed scaffolds, its role in bone and cartilage defect management, and its enhanced efficacy when combined with molecules like Kartogenin (KGN) for fibrocartilage zone repair. Significant attention is paid to tissue engineering for meniscal interventions, where a combination of KGN, PRP, and bone marrow-derived mesenchymal stem cells are under exploration. Within the sphere of osteochondral regenerative therapy, the synergy of PRP with Bone Marrow Aspirate Concentrate (BMAC) represents a noteworthy leap towards cartilage regeneration. The innovative incorporation of PRP with biomaterials like hydroxyapatite and graphene oxide further underscores its versatility in supporting structural integrity and ensuring sustained growth factor release. However, while PRP’s autologous and nontoxic nature makes it an inherently safe option, concerns arising from its preparation methods, particularly with bovine thrombin, necessitate caution. As of 2023, despite the burgeoning promise of PRP in bone healing, the quest for its standardization, optimization, and substantiation through rigorous clinical trials continues. This comprehensive review elucidates the contemporary applications, challenges, and future trajectories of PRP in orthopedics, aiming to spotlight areas primed for further research and exploration.

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Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis

Cited by 19 publications

References 23 publications

Update on the Use of Platelet-Rich Plasma Injections in the Management of Musculoskeletal Injuries: A Systematic Review of Studies From 2014 to 2021

Update on the Use of Platelet-Rich Plasma Injections in the Management of Musculoskeletal Injuries: A Systematic Review of Studies From 2014 to 2021

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Platelet-rich plasma in orthopedics: Bridging innovation and clinical applications for bone repair

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