Platelet-Rich Plasma Facial Rejuvenation: Myth or Reality?

Atiyeh, Bishara S.; Oneisi, Ahmad; Ghieh, Fadi

doi:10.1007/s00266-021-02300-9

Cited by 12 publications

(10 citation statements)

References 75 publications

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“…Treatments using PRP can revitalize the skin [ 7 ]. Various “split-face” studies (patients served as their own control, injecting PRP randomized to either the left or right side of their face) are undertaken to illustrate the benefit of PRP for rejuvenation [ 8 ]. It is particularly worth mentioning that the combination of PRP and hyaluronic acid resulted in a notable improvement in skin condition [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts

Weng

Cheng

Lee

et al. 2021

IJMS

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As a source of growth factors for expediting wound healing and tissue regeneration, plasma-rich plasma (PRP) has been extensively applied in diverse fields including orthopaedics, ophthalmology, oral and maxillofacial surgery, dentistry, and gynaecology. However, the function of PRP in metabolic regulations remains enigmatic. A standardized method was devised herein to enrich growth factors and to lyophilize it as enhanced PRP (ePRP) powder, which could become ubiquitously available without mechanical centrifugation in clinical practice. To identify metabolic reprogramming in human dermal fibroblasts under ePRP treatment, putative metabolic targets were identified by transcriptome profiling and validated for their metabolic effects and mechanism. ePRP does not only promote wound healing but re-aligns energy metabolism by shifting to glycolysis through stimulation of glycolytic enzyme activity in fibroblasts. On the contrary, oxygen consumption rates and several mitochondrial respiration activities were attenuated in ePRP-treated fibroblasts. Furthermore, ePRP treatment drives the mitochondrial resetting by hindering the mitochondrial biogenesis-related genes and results in a dampened mitochondrial mass. Antioxidant production was further increased by ePRP treatment to prevent reactive oxygen species formation. Besides, ePRP also halts the senescence progression of fibroblasts by activating SIRT1 expression. Importantly, the glycolytic inhibitor 2-DG can completely reverse the ePRP-enhanced wound healing capacity, whereas the mitochondrial inhibitor oligomycin cannot. This is the first study to utilize PRP for comprehensively investigating its effects on the metabolic reprogramming of fibroblasts. These findings indicate that PRP’s primary metabolic regulation is to promote metabolic reprogramming toward glycolytic energy metabolism in fibroblasts, preserving redox equilibrium and allowing anabolic pathways necessary for the healing and anti-ageing process.

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Section: Introductionmentioning

confidence: 99%

Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts

Weng

Cheng

Lee

et al. 2021

IJMS

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confidence: 99%

“…1 Briefly speaking, the idea is particularly encouraging and appealing; however, given the limited supporting literature, it must be determined if we are dealing with a myth or a real opportunity. 1…”

mentioning

confidence: 99%

“…Actually, skin rejuvenation by using PRP is highly controversial, as it seems that the majority of clinical case studies are scientifically inconsistent and unreliable, with respect to the more rigorous open randomized clinical trials. 1 A possible reason is the puzzling complexity of actions associated with autologous PRP, which renders any good experimental and scientific attempt an empirical approach. 2 3 Yet, Lei et al, in a systematic review on a total of 108 articles, reported that PRP should play a major role in tissue rejuvenation.…”

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confidence: 99%

“…This attempt might simply be described, therefore, as the use of an autologous blood extract, for example, PRP or ACS, which are both particularly enriched in biomolecules and growth factors and adapted for skin rejuvenation and musculoskeletal disorders. 1 Briefly speaking, the idea is particularly encouraging and appealing; however, given the limited supporting literature, it must be determined if we are dealing with a myth or a real opportunity. 1 Actually, skin rejuvenation by using PRP is highly controversial, as it seems that the majority of clinical case studies are scientifically inconsistent and unreliable, with respect to the more rigorous open randomized clinical trials.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Exokine and the Youth-Boosting Treatment Based on One's Own Serum: Wheat and Chaff

Magistretti¹,

Bertossi

Pirayesh³

et al. 2022

Facial Plast Surg

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Within the field of skin rejuvenation, clinicians have broadened the application of proven therapies toward antiaging medicine. Specifically, both platelet-rich plasma (PRP) and autologous-conditioned serum (ACS) have received great consideration among experts for novel indications. While the medical research focused on ACS is strengthened in their evidence and supported by promising outcomes, much more debates exist regarding the efficacy of PRP. Despite limited supporting literature to date, physicians and surgeons should be encouraged to explore the use of these approaches and in shedding further light on their potential benefits by contributing new evidence from basic and clinical scientific investigation.

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Nonsurgical Esthetics for Facial Rejuvenation and Hair Restoration Using Autologous PRP and Adipose Tissue Concentrate

Everts

2023

Image-Guided Aesthetic Treatments

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Platelet-Rich Plasma Facial Rejuvenation: Myth or Reality?

Cited by 12 publications

References 75 publications

Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts

Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts

Exokine and the Youth-Boosting Treatment Based on One's Own Serum: Wheat and Chaff

Nonsurgical Esthetics for Facial Rejuvenation and Hair Restoration Using Autologous PRP and Adipose Tissue Concentrate

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