Platelet-rich plasma contributes to chondroprotection by repairing mitochondrial function via AMPK/NF-κB signaling in osteoarthritic chondrocytes

Li, Ming; Hong, Han; Chen, Liu; Li, Haohan

doi:10.1016/j.tice.2022.101830

Cited by 4 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though the exact mechanisms of action are largely unknown, anti-inflammatory and immune-modulating functions of PRP have been postulated ( Bennell et al, 2017 ), along with disease modifying effects at both cartilage and synovial level ( Boffa et al, 2021 ). Despite a large number of molecular mechanisms involved in OA have been elucidated ( Moussa et al, 2017 ; Li et al, 2022 ; Yao et al, 2023 ), WNT signaling pathway and IL-1β-mediated signaling have gained importance in the disease pathogenesis during the last years. We will herein review the pathogenic significance of these mechanisms, with a focus on the possible roles of PRP in modulating such processes.…”

Section: Introductionmentioning

confidence: 99%

The role of WNT and IL-1 signaling in osteoarthritis: therapeutic implications for platelet-rich plasma therapy

et al. 2023

View full text Add to dashboard Cite

Different from inflammatory arthritis, where biologicals and targeted synthetic molecules have revolutionized the disease course, no drug has demonstrated a disease modifying activity in osteoarthritis, which remains one of the most common causes of disability and chronic pain worldwide. The pharmacological therapy of osteoarthritis is mainly directed towards symptom and pain relief, and joint replacement is still the only curative strategy. Elucidating the disease pathophysiology is essential to understand which mechanisms can be targeted by innovative therapies. It has extensively been demonstrated that aberrant WNT and IL-1 signaling pathways are responsible for cartilage degeneration, impaired chondrocyte metabolism and differentiation, increased extracellular matrix degradation, and altered subchondral bone homeostasis. Platelet-rich plasma is an autologous blood derivative containing a concentration of platelets that is much higher than the whole blood counterpart and has shown promising results in the treatment of early knee osteoarthritis. Among the proposed mechanisms, the modulation of WNT and IL-1 pathways is of paramount importance and is herein reviewed in light of the proposed regenerative approaches.

show abstract