Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis

Evans, Adam; Mwangi, James M.; Pope, Rand W.; Ivanic, Mirjana G; Botros, Mina; Glassman, Gabriella E.; Pearce, F. Bennett; Kassis, Salam

doi:10.1080/09546634.2020.1770171

Cited by 34 publications

(41 citation statements)

References 65 publications

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“…The data on the positive effect of PRP on hair growth in AGA, obtained over the past few years, should prompt clinicians to consider PRP as a valuable alternative to existing treatment methods, given its autologous nature and minimal side effects [27].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Pakhomova

Smirnova

2020

IJMS

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Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs. To assess cell proliferation antibodies to β-catenin, CD34, Ki67, and to Dkk-1 were used. Results. PRP treatment was more effective than minoxidil therapy (p = 0.005). Complex therapy turned out to be more effective than minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). After applying PRP the absolute and relative values of the β-catenin and CD34 expression area increased; an increase in Ki67+ index was also significant. Conclusions: PRP can be considered as a treatment option for AGA. Combined PRP and minoxidil use seems promising for the treatment of AGA. PRP increase in the proliferative activity of HF cells and improves hair morphology in patients with AGA.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Pakhomova

Smirnova

2020

IJMS

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“…The high prevalence of androgenetic alopecia and the limited efficacy of current available treatments have prompted the clinical investigation with PRP. A recent meta-analysis has shown that PRP can improve hair density and thickness [38]. Usually, several sessions of microneedling with PRP are needed, often associated to minoxidil [39].…”

Section: Other Conditionsmentioning

confidence: 99%

Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization

Andı́a

Perez‐Valle

Amo

et al. 2020

IJMS

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The complex biology of platelets and their involvement in tissue repair and inflammation have inspired the development of platelet-rich plasma (PRP) therapies for a broad array of medical needs. However, clinical advances are hampered by the fact that PRP products, doses and treatment protocols are far from being standardized. Freeze-drying PRP (FD-PRP) preserves platelet function, cytokine concentration and functionality, and has been proposed as a consistent method for product standardization and fabrication of an off-the-shelf product with improved stability and readiness for future uses. Here, we present the current state of experimental and clinical FD-PRP research in the different medical areas in which PRP has potential to meet prevailing medical needs. A systematic search, according to PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analyses) guidelines, showed that research is mostly focused on wound healing, i.e., developing combination products for ulcer management. Injectable hydrogels are investigated for lumbar fusion and knee conditions. In dentistry, combination products permit slow kinetics of growth factor release and functionalized membranes for guided bone regeneration.

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“…They stated that PRP is an autologous treatment that has no serious side effects and effectively improves hair density and thickness in men and women with AGA. 38 In a systematic review of other meta-analysis findings, the positive effects of the PRP method were assessed and a significant increase in hair density and thickness of patients, who were treated with this method, was observed. 39 Various oral and topical medicines have been introduced for treating hair loss.…”

Section: Discussionmentioning

confidence: 99%

“…In a systematic study by Evans et al, 687 patients were studied and the results of their meta‐analyses showed that PRP treatment increases hair density and thickness. They stated that PRP is an autologous treatment that has no serious side effects and effectively improves hair density and thickness in men and women with AGA 38 . In a systematic review of other meta‐analysis findings, the positive effects of the PRP method were assessed and a significant increase in hair density and thickness of patients, who were treated with this method, was observed 39 …”

Section: Discussionmentioning

confidence: 99%

“…Minoxidil possesses antibiotic and mitogenic properties. Finasteride on the other hand inhibits 5α‐reductase and therefore reduces dihydrotestosterone levels and extends the anagen phase that leads to an increase of thickness and number of hairs 12‐39 . Dutasteride is another medication used for the treatment of AGA, though it is not approved by the FDA.…”

Section: Introductionmentioning

confidence: 99%

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Systematic review of platelet‐rich plasma in treating alopecia: Focusing on efficacy, safety, and therapeutic durability

Roohaninasab

Goodarzi

Ghassemi

et al. 2021

Dermatologic Therapy

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Considering the different forms, alopecia could be a very common condition with particular therapeutic concerns; thus, recent therapies still require further assessments. Aim of this systematic review was to evaluate efficacy, safety, and therapeutic durability of platelet rich plasma (PRP) in treating various forms of alopecia. A total of 64 articles were found through a systematic search, and eight original articles were included in the study, based on inclusion/exclusion criteria. In most studies (62.5%) patients' conditions had improved by receiving PRP therapy; these cases experienced an increase in growth and thickness of hair. Simultaneous use of PRP and Minoxidil demonstrated the highest rate of improvement and satisfaction. The highest efficacy in patients with alopecia areata was 76% and the lowest efficacy was 31.7% and in patients with androgenetic alopecia the highest efficacy was 42.75% and the lowest reported efficacy was 25.55%. The main side effect was pain due to PRP injection, which disappeared after ending the treatment and only one article reported more serious side effects. Recurrence after treatment was also reported in only one article. PRP is a safe and easy method for treating hair loss and has limited adverse effects. Optimization of this method depends on dosage, number of sessions and their intervals, and injection techniques. According to the results, the use of PRP due to its relatively high efficiency, low and tolerable side effects, and low recurrence rate can be a good method for the treatment of alopecia and hair loss.

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Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis

Cited by 34 publications

References 65 publications

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization

Systematic review of platelet‐rich plasma in treating alopecia: Focusing on efficacy, safety, and therapeutic durability

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