Platelet-Rich Plasma: A Promising Regenerative Therapy in Gynecological Disorders

Abstract

Platelet-rich plasma (PRP) could be understood as a special preparation of plasma in which the concentration of platelet is immensely high. This rationale for plasma use has been in the medical science for many years with plenty of success in various fields where it was inculcated, bringing dramatically favorable and better outcomes in terms of disease management and prognosis. PRP has been widely used in orthopedics from the very beginning, but in the past few years its use has been extended to other fields too, such as obstetrics and gynecology. From the very onset of the introduction of platelet-rich plasma in gynecology, there had been constant research being carried out all around the globe in order to scientifically prove and confirm its exact role in the management of gynecological problems. Regenerative medicine in gynecology was among the first areas where the platelet-rich plasma was implemented and has substantially given great results, which encouraged further extensive research to be carried out in other spectrums of gynecology. The implications of such great struggles ultimately gave way to evidence suggesting the importance of platelet-rich plasma in managing gynecological disorders like Asherman's syndrome, urinary incontinence, genital fistulas, thin endometrium, etc. This review article collectively summarizes the various use of platelet-rich plasma in gynecology.

El plasma rico en plaquetas como una estrategia prometedora para el tratamiento del síndrome de Asherman

“…Los estudios también aseguran que esta terapia debe evitarse en personas con trastornos de la coagulación, pues su aplicación empeoraría su estado general rápidamente. Otras situaciones donde debe evitarse son en infecciones activas, tratamiento actual con AINES, embarazadas y madres en periodo de lactancia (Varghese & Acharya, 2022).…”

Use of Autologous Platelet Rich Plasma (A-PRP) for Postpartum Perineal Repair Failure: A Case Report

“…A recent publication has reviewed the various research works on the use of plateletrich plasma in gynecology [23]. Various scientific observations were obtained, which have the potential to bring about a great revolution in obstetrics and gynecology.…”

“…Indeed, promising clinical data are arising for thin endometrium, recurrent genital fistulas, ovarian abnormalities or poor ovarian reserve, Asherman's syndrome, urinary stress incontinence, etc. [23].…”

Method to obtain a plasma rich in platelet- and plasma-growth factors based on water evaporation

“…These pathologies range from musculoskeletal disorders, oral and maxillofacial surgery and in dermatology, among others [ 1 – 4 ]. Due to its easy preparation, its low-cost processing and its autologous nature [ 5 ], PRP has gained great value as a treatment in regenerative medicine in the last few years [ 6 ].…”