Platelet-Rich Plasma

Hunter, Corey; Davis, Timothy T.; Fadadu, Priyal

doi:10.1007/978-3-319-68841-1_38

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Data from the selected studies were extracted and compiled into online supplementary table 1 23. Data were collected regarding protocol for PRP preparation, processing machine, spinning parameters, final platelet count, final WBC count and growth factor analysis.…”

Section: Methodsmentioning

confidence: 99%

Review of concentration yields in commercially available platelet-rich plasma (PRP) systems: a call for PRP standardization

Fadadu

Mazzola

Hunter

et al. 2019

Reg Anesth Pain Med

102

126

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Platelet-rich plasma (PRP) has become increasingly popular in pain medicine with hopes of becoming a safe, effective alternative to routine treatments. However, given its autologous nature, PRP injectate may differ depending on the specific manufacturer and protocol. Currently, there is no standardization of reporting protocol. This systematic review compiles and standardizes values on PRP preparation and final product composition of platelets, white cell count, and growth factors for ease of comparison. On review of 876 studies, 13 studies were selected according to our inclusion criteria. Data from 33 PRP systems and protocols were extracted and standardized. Overall, PRP final product concentrations as well as PRP preparation protocols varied widely between systems. However, platelet concentration was directly correlated with both volume of blood collected and device centrifugal force. In conclusion, there is a large heterogeneity between PRP separation systems that must be resolved for proper study of this promising treatment.

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Section: Methodsmentioning

confidence: 99%

Review of concentration yields in commercially available platelet-rich plasma (PRP) systems: a call for PRP standardization

Fadadu

Mazzola

Hunter

et al. 2019

Reg Anesth Pain Med

102

126

View full text Add to dashboard Cite

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Treatment Of Knee Osteoarthritic Pain with Platelet-Rich Plasma: A Systematic Review of Clinical Studies

Aiyer

Noori²,

Schirripa

et al. 2021

Pain Manag.

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Introduction: Knee osteoarthritis is a degenerative joint disease that is secondary to degradation of articular cartilage, reformation of subchondral bone through degradation and proliferation as well as presence of synovitis. Materials & methods: This systematic review was conducted and reported as per Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: A total of 30 of the 48 comparators showed statistically significant superiority with platelet-rich plasma (PRP) compared with a control, while the other 16 comparators showed no significant difference between PRP and the comparator. Conclusion: We can only recommend PRP for patients with early-stage osteoarthritis (I or II) and who are aged below 65, based on our findings. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) recommendations, while studies reviewed were randomized controlled studies, and therefore, high grade, due to variance in imprecision, risk of bias and inconsistency among the 37 studies, it would be reasonable to rate this paper as subjectively moderate.

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Platelet-Rich Plasma

Cited by 2 publications

References 29 publications

Review of concentration yields in commercially available platelet-rich plasma (PRP) systems: a call for PRP standardization

Review of concentration yields in commercially available platelet-rich plasma (PRP) systems: a call for PRP standardization

Treatment Of Knee Osteoarthritic Pain with Platelet-Rich Plasma: A Systematic Review of Clinical Studies

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