Platelet-Rich Plasma

Wu, Peter I-Kung; Diaz, Robert; Borg‐Stein, Joanne

doi:10.1016/j.pmr.2016.06.002

Cited by 210 publications

(192 citation statements)

References 177 publications

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“…Recent studies state that PRP is capable to enhance the repair of tissues with poor healing ability as in the case of cartilage tissue [42]. Platelets play an important role in wound healing and hemostasis.…”

Section: Discussionmentioning

confidence: 99%

Efficiency of Platelet-rich Plasma (PRP) Compared to Ozone Infiltrations on Patellofemoral Pain Syndrome and Chondromalacia: A Non- Randomized Parallel Controlled Trial

Fernández-Cuadros¹,

Albaladejo-Florín²,

Algarra-López³

et al. 2017

Divers Equal Health Care

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Objective: 1) to determine the efficiency of PRP compared to Ozone Infiltrations on pain, function and quality of life (QoL) in patients with Patellofemoral Pain Syndrome (PFPS) and Chondromalacia. Material and methods:Prospective non-randomized controlled-trial, comparing two treatment protocols in parallel design, on 48 patients (24 in each group), with PFPS and Chondromalacia , who were treated at Santa Cristina's University Hospital, from January 2014 to May 2017. The PRP-protocol consisted of 3 sessions (1 session/week) of platelet-rich plasma (PRP), by an intra-articular infiltration of 3 ml. To obtain PRP, a kit device from EXACTECH (Accelerate Concentration System Device and Drucker Centrifuge was used.The Ozone-protocol consisted of 4 sessions (1 per week) of a medical mixture of Oxygen-Ozone (95%-5%) 20 ml, at a 20 ug/ml concentration, infiltrated intra-articularly. Pain, function, stiffness and Quality of Life were measured by Western Ontario and Mc Master Universities Index for Osteoarthritis (WOMAC) and Visual Analogical Scale (VAS) at baseline/end of treatment.Results: At baseline, age, sex, ratio male to female, clinical chondromalacia grades and symptom severity such as pain, stiffness and function were similar between groups of treatment. In both groups, the most common grade of chondromalacia was 2º grade (41.8% in PRP, 50% in Ozone), followed by 3º (37.6% in PRP, 33.4% in Ozone) and 4º (16.6% in both PRP and Ozone). When treatment protocols are analyzed separately, both PRP and Ozone were capable to produce pain relief (measured by VAS and WOMAC pain subscale), and improvement in function and rigidity (measured by WOMAC subscales), with a significant statistical level (p<0.05). In the case of pain, Ozone is even more effective than PRP (1.46 points on VAS scale and 2.95 points on WOMAC pain subscale) (p<0.05).Conclusion: PRP and ozone produce pain relief, function recovery and quality of life improvement in PFPS and chondromalacia, measured by WOMAC and VAS scores. In the case of pain severity, ozone produces even greater pain relief. PRP and Ozone are safe and effective modalities for the management of PFPS and chondromalacia.

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Section: Discussionmentioning

confidence: 99%

Efficiency of Platelet-rich Plasma (PRP) Compared to Ozone Infiltrations on Patellofemoral Pain Syndrome and Chondromalacia: A Non- Randomized Parallel Controlled Trial

Fernández-Cuadros¹,

Albaladejo-Florín²,

Algarra-López³

et al. 2017

Divers Equal Health Care

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“…Препарат ОТП готовится ex tempore путем сепара-ции аутологичной крови (т. е. взятой у самого пациента, обычно до 100 мл) -двухэтапного центрифугирования, позволяющего разделить плазму и клеточные элементы. Концентрация тромбоцитов в препарате ОТП составляет около 1 млн на 1 мкл, что примерно в 5 раз выше содержа-ния этих элементов в нативной крови [56,57].…”

Section: обогащенная тромбоцитами плазмаunclassified

“…Эти пептиды выступают в качестве тканевых гормонов и важнейших регуляторов репарации повреж-денной ткани, играя ключевую роль в процессе пролифе-рации, миграции и дифференциации стволовых клеток че-ловеческого организма [56,57].…”

Section: обогащенная тромбоцитами плазмаunclassified

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Каратеев¹,

Лила²

2018

rsp

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“…provokes intensive epidermization of the ulcer and improved blood supply. From the other hand, the presence of immunoglobulin and a lot of cytokines foster cleaning of the lesion, prevent its infection; activate immune anti-inflammatory local response of the body 8 . Underthe auto-dermoplasty,all these measures result inintenseregenerative processes and recovery of the patient.…”

Section: Case Presentationmentioning

confidence: 99%

Hypertensive ulcer of lower extremity (Martorell's syndrome): clinical case with the treatment improvement

Igor

Vasyl

Andrii

et al. 2017

Bangladesh J Med Sci

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Introduction. Martorell's syndrome (MS) is a rare disease associated with chronic progressive hypertension which complicates ulcer defects on the extremities. It requests individual approach to treatment with antihypertensive medications, which help to reduce pathogenesis of the ulceration development. Therefore the aim of this study was to find new treatment methods of this disease. Case presentation. A 83-year-old female Ukrainian patient presented with an ulcer on the right calf, which was extremely painful at night. After all examination it was diagnosed: stage 2 hypertension, high risk, Martorell's syndrome, right lower limb trophic ulcer of the hypertonic genesis. For the treatment of MS we used the combination therapy, which included tissue suturing on the whole area of the ulcer and auto-dermoplasty with PRP applications. After that was noted intense regenerative processes and recovery of the patient. Conclusions. Chronic leg ulcers are rarely caused by Martorell's syndrome. It requires the complex approach to the treatment under obligatory antihypertensive therapy with its further prolongation. The complex therapy improved by the platelet-rich auto plasma activates the therapeutic effect, which results in intensive healing of the ulcer and faster improvement in pain relief. The platelet-rich auto plasma may become an economic method of treatment the ulcers of any genesis.

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Platelet-Rich Plasma

Cited by 210 publications

References 177 publications

Efficiency of Platelet-rich Plasma (PRP) Compared to Ozone Infiltrations on Patellofemoral Pain Syndrome and Chondromalacia: A Non- Randomized Parallel Controlled Trial

Efficiency of Platelet-rich Plasma (PRP) Compared to Ozone Infiltrations on Patellofemoral Pain Syndrome and Chondromalacia: A Non- Randomized Parallel Controlled Trial

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Hypertensive ulcer of lower extremity (Martorell's syndrome): clinical case with the treatment improvement

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