Platelet-Rich Fibrin in third molar surgery. Systematic review and meta-analysis protocol

Abstract

Objective: The objective of this systematic review is to assess the effectiveness and safety of platelet rich fibrin (PRF) in third molar surgery. Data sources: A comprehensive search strategy is meant to be used in an attempt to identify all relevant RCTs, ongoing investigation reported in specialty congresses and trials regardless of language or publication status (published, unpublished, in press, and in progress). Search will be conducted in The Cochrane Central Register of Controlled Trials (CENTRAL); PUBMED; Embase; Lilacs, and also conduct a search through trial registries of the International Clinical Trials Registry Platform (ICTRP), Word Health Organization (WHO) and the ClinicalTrials.gov, US National Institutes of Health (NIH), grey literature search and specialty congress will be reviewed. Eligibility criteria: We will include randomised trials evaluating the effect of PRF on wound healing after third molar surgery. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias using Cochrane 'risk of bias' tool. We will pool the results using meta-analysis and will apply the GRADE system to assess the certainty of the evidence for each outcome. Ethics and dissemination: As researchers will not access information that could lead to the identification of an individual participant, obtaining ethical approval was waived. Keywords: platelet-rich fibrin; third molars; wound healing; systematic review