Platelet Rich Fibrin in Periodontal Regeneration

Arunachalam, Muthukumaraswamy; Pulikkotil, Shaju Jacob; Nath, Sonia

doi:10.2174/1874210601610010174

Cited by 25 publications

(23 citation statements)

References 40 publications

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“…[242526] The failure in our study for PRP to show superior regeneration compared to OFD may be because of conducive environment for the above described complicated time dependent periodontal wound healing phenomena. [2427282930] Comparing percentage of defect fill between Group A and Group B - it was not found to be statistically significant.…”

Section: Discussionmentioning

confidence: 95%

Use of platelet rich plasma in the management of periodontal intra-osseous defects: A clinical study

Jalaluddin

Singh

Jayanti

et al. 2017

J Int Soc Prevent Communit Dent

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Background:Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment, and alveolar bone around the affected tooth. Alveolar bone support and attachment apparatus regeneration has been achieved through various processes and have given elusive results. An expedient and cost-effective approach to obtain autologous platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β is the use of platelet-rich plasma (PRP). PRP is obtained by sequestrating and concentrating platelets by gradient density centrifugation.Aims:The current study was aimed at evaluating the regenerative potential of platelet-rich plasma in comparison with open flap debridement.Settings and Designs:This study was a randomized controlled clinical trial conducted in the Department of Periodontics and Oral Implantology, KIDS, Bhubaneswar, Odisha.Materials and Methods:Twenty periodontal infrabony defects in 10 patients; 6 males and 4 females of age between 25–45 years were included in this study and were followed up for a period of 6 months.Statistical Analysis:Both the groups showed a mean plaque index of 2.10 and 2.50 at baseline, 1.75 and 2.05 at 3 months, and 1.28 and 1.53 at the end of 6 months. The mean reduction of 0.35 and 0.45 at three months and 0.82 and 0.97 at six months was achieved, which was statistically significant. (P < 0.001). When comparison was done between the two groups it was not found to be statistically significant (P < 0.05). In each of the group there was definitive reduction in plaque score over a period of time.Results and Conclusion:There was no statistically significant difference in the treatment outcome between open flap debridement and PRP alone. Platelet-rich plasma application holds promise and needs further exploration.

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Section: Discussionmentioning

confidence: 95%

Use of platelet rich plasma in the management of periodontal intra-osseous defects: A clinical study

Jalaluddin

Singh

Jayanti

et al. 2017

J Int Soc Prevent Communit Dent

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“…However, it has been reported that low levels of TNF‐α and IL‐6 in PMC are suitable for tendon healing and reduced scar formation . Platelet‐rich fibrin (PRF; a fibrin clot in which contains the platelet cellular debris with their cytokines) also contains many of the above‐mentioned growth factors such as PDGF, TGF‐β, VEGF, EGF and IGF‐1 . These alternatives may be particularly useful in patient‐dependent cases where local injection may not be applicable.…”

Section: Overview Of Platelet Biologymentioning

confidence: 99%

Platelet biology in regenerative medicine of skeletal muscle

2018

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Platelet-based applications such as platelet-rich plasma (PRP) and platelet releasate have gained unprecedented attention in regenerative medicine across a variety of tissues as of late. The rationale behind utilizing PRP originates in the delivery of key cytokines and growth factors from α-granules to the targeted area, which in turn act as cell cycle regulators and promote the healing process across a variety of tissues. The aim of the present review is to assimilate current experimental evidence on the role of platelets as biomaterials in tissue regeneration, particularly in skeletal muscle, by integrating findings from human, animal and cell studies. This review is composed of 3 parts: firstly, we review key aspects of platelet biology that precede the preparation and use of platelet-related applications for tissue regeneration. Secondly, we critically discuss relevant evidence on platelet-mediated regeneration in skeletal muscle focusing on findings from (i) clinical trials, (ii) experimental animal studies and (iii) cell culture studies; and thirdly, we discuss the application of platelets in the regeneration of several other tissues including tendon, bone, liver, vessels and nerve. Finally, we review key technical variations in platelet preparation that may account for the large discrepancy in outcomes from different studies. This review provides an up-to-date reference tool for biomedical and clinical scientists involved in platelet-mediated tissue regenerative applications.

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“…Las plaquetas son responsables por la activación y liberación de importantes biomoléculas, incluyendo proteínas específicas, factores de crecimiento como el factor de crecimiento derivado de plaquetas (FCDP), factores de la coagulación, moléculas de adhesión, citoquinas/quimiocinas y factores angiogénicos; capaces de estimular la proliferación y activación de fibroblastos, macrófagos, neutrófilos y células mesenquimáticas (27)(28)(29) . Los leucocitos juegan un importante rol en el proceso de cicatrización.…”

Section: Discussionunclassified