Platelet rich fibrin as a gingival tissue regeneration enhancer

Petrescu, Nausica Bianca; Mirica, Ioana Codruta; Miron, Richard J.; Câmpian, Radu Septimiu; Lucaciu, Ondine

doi:10.1016/j.jds.2020.08.014

Cited by 3 publications

(3 citation statements)

References 9 publications

(12 reference statements)

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“…Sharma et al (50) recorded that PRF is significantly better in promoting soft tissue healing and hastens bone formation in extraction socket. Similarly, Petrescu BN (51) proved the efficacy of PRF as a wound healing accelerator of gingival tissue. In comparison to gelatin sponge, results showed high statistical significant difference (p=.001).…”

Section: Discussionmentioning

confidence: 94%

Efficacy of Platelet Rich Fibrin Versus Gelatin Sponge or Tranexamic Acid on Hemostasis and Wound Healing Following Tooth Extraction in Patients On Anticoagulant Therapy

Mansour

Ateia

2022

Egyptian Dental Journal

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Section: Discussionmentioning

confidence: 94%

Efficacy of Platelet Rich Fibrin Versus Gelatin Sponge or Tranexamic Acid on Hemostasis and Wound Healing Following Tooth Extraction in Patients On Anticoagulant Therapy

Mansour

Ateia

2022

Egyptian Dental Journal

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“…Publications over the last few years concerning platelet-rich fibrin include practically all the fields of dentistry. It has been used for treating the perforation of the bottom of the pulp cavity in combination with MTA, multiple gingival recessions, or periodontal diseases [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

The Assessment of the Usefulness of Platelet-Rich Fibrin in the Healing Process Bone Resorption

et al. 2022

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The main subject of this research was the use of PRF in dental surgery aimed at preventing changes in alveolar height and width after tooth extraction. Due to the large growth factor content, it seems to be particularly useful in bone loss management starting from the simplest loss occurring after tooth extraction through loss resulting from tooth resection ending with loss caused by large bone cysts. The study was performed on 50 patients. The extraction of two maxillary or mandibular homonymous teeth was carried out in each patient, where PRF was placed in one alveolus while the other alveolus was left empty. Then, the alveoli were surgically managed with a split flap technique. On the extraction day, after 10 days, and after 6 months, the alveolar process was measured, soft tissues healing was assessed, and imaging examinations were analyzed. It was proved that the healing of soft tissues in the PRF group was better. In the PRF group after 6 months from surgery, the newly formed bone had higher grayscale values in volumetric tomography (CBCT). Moreover, the reduced atrophy of the alveolar process at the site of the extracted tooth was proved in this study.

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“…Various studies have reported other biological properties of L-PRF, such as enhancing wound healing, diminishing post-operative pain and minimizing the risk of infection ( Bi et al., 2020 ; Petrescu et al., 2021 ). Furthermore, recent research in this also reported an antimicrobial effect of L-PRF against key periodontal pathogens ( Castro et al., 2019b ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic Porphyromonas gingivalis and Within Multi-Species Biofilm: A Pilot Study

Sánchez

Verspecht

Castro

et al. 2021

Front. Cell. Infect. Microbiol.

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Leucocyte- and platelet rich fibrin (L-PRF) is an autologous biomaterial used in regenerative procedures. It has an antimicrobial activity against P. gingivalis although the mechanism is not fully understood. It was hypothesized that L-PRF exudate releases hydrogen peroxide and antimicrobial peptides that inhibit P. gingivalis growth. Agar plate and planktonic culture experiments showed that the antimicrobial effect of L-PRF exudate against P. gingivalis was supressed by peroxidase or pepsin exposure. In developing multi-species biofilms, the antimicrobial effect of L-PRF exudate was blocked only by peroxidase, increasing P. gingivalis growth with 1.3 log genome equivalents. However, no effect was shown on other bacteria. Pre-formed multi-species biofilm trials showed no antimicrobial effect of L-PRF exudate against P. gingivalis or other species. Our findings showed that L-PRF exudate may release peroxide and peptides, which may be responsible for its antimicrobial effect against P. gingivalis. In addition, L-PRF exudate had an antimicrobial effect against P. gingivalis in an in vitro developing multi-species biofilm.

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Platelet rich fibrin as a gingival tissue regeneration enhancer

Cited by 3 publications

References 9 publications

Efficacy of Platelet Rich Fibrin Versus Gelatin Sponge or Tranexamic Acid on Hemostasis and Wound Healing Following Tooth Extraction in Patients On Anticoagulant Therapy

Efficacy of Platelet Rich Fibrin Versus Gelatin Sponge or Tranexamic Acid on Hemostasis and Wound Healing Following Tooth Extraction in Patients On Anticoagulant Therapy

The Assessment of the Usefulness of Platelet-Rich Fibrin in the Healing Process Bone Resorption

Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic Porphyromonas gingivalis and Within Multi-Species Biofilm: A Pilot Study

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