Platelet-rich fibrin: an autologous biomaterial for healing assistance of pharyngeal repair in total laryngectomy

Inflammation‐Based Score (Combination of Platelet Count and Neutrophil‐to‐Lymphocyte Ratio) Predicts Pharyngocutaneous Fistula After Total Laryngectomy

“…Platelets are differentiated from megakaryocytes, which are induced by interleukin‐6, an inflammatory cytokine 30,31 . One study reported that, the application of platelet‐rich fibrin (PRF) in suture repair of the pharynx reduces the incidence of PCF; PRF influences the expression of various cytokines and growth factors 32 . Another report revealed that the expression of bradykinin 1 receptor, which plays an important role in the inflammatory response, is a risk factor for PCF 33 …”

“…30,31 One study reported that, the application of platelet-rich fibrin (PRF) in suture repair of the pharynx reduces the incidence of PCF; PRF influences the expression of various cytokines and growth factors. 32 Another report revealed that the expression of bradykinin 1 receptor, which plays an important role in the inflammatory response, is a risk factor for PCF. 33 In a study by Aires et al involving 157 patients with squamous cell carcinoma of the larynx, patients with NLR >2.5, exhibited a higher risk of developing PCF after total laryngectomy.…”

Can L-PRF be helpful for delayed deep wound healing after a tracheotomy or lymph node dissection in a pN0 status?: A case report

“…According to literature, L-PRF is mostly used for regenerative procedures in superficial skin tissue, but the use in deep tissue is rarely described, and only a few cases have been reported [11] , [12] , [13] . One study showed the use of L-PRF membranes in the parapharyngeal area after total laryngectomy, to improve healing and to decrease the incidence of postoperative pharyngocutaneous fistulas [11] . The beneficial effect of L-PRF in the healing process can be explained by the high concentration of platelets and leukocytes, together with the long-term release of growth factors [10] , [14] .…”

Oncological safety of platelet-rich fibrin application on the pharyngeal closure after total laryngectomy

“…We thank Spartalis and Troupis [1], for their constructive comments on our article "Platelet-rich fibrin: an autologous biomaterial for healing assistance of pharyngeal repair in total laryngectomy" [2] and the editor for giving us the opportunity to reply.…”