Platelet Products

Callan, Mary Beth; Marryott, Kimberly

doi:10.1002/9781118933053.ch5

Cited by 4 publications

(2 citation statements)

References 66 publications

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“…19 In dogs, platelets are uncommonly transfused to patients with thrombocytopenia, however, because of a lack of ready availability of appropriate products. 3,20,21 Additionally, the costs and logistics involved in obtaining and maintaining stores of fresh platelet concentrates are often prohibitive. Canine cryopreserved platelet concentrates (CPP) generated from apheresed platelets stabilized with 6% dimethyl sulfoxide (DMSO) are commercially available in the United States.…”

mentioning

confidence: 99%

Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial

Goggs

Brainard

LeVine

et al. 2020

Veterinary Internal Medicne

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Background: Thrombocytopenia in dogs is common in critical care medicine, but availability of fresh platelet concentrates in veterinary medicine can be limiting. Lyophilized platelets have long shelf-lives and can be easily transported, stored, and administered in various settings. Objective: To evaluate the efficacy and safety of a novel trehalose-stabilized canine lyophilized platelet product in thrombocytopenic dogs with clinically-evident bleeding. Animals: Eighty-eight dogs with platelet counts <50 × 10 3 /μL and a standardized bleeding assessment tool (DOGiBAT) score ≥2. Methods: Multicenter, randomized, non-blinded, non-inferiority clinical trial comparing dimethyl sulfoxide (DMSO)-stabilized cryopreserved platelet concentrates (CPP) with trehalose-stabilized lyophilized platelets (LP) for control of bleeding in thrombocytopenic dogs. Dogs were randomized to receive 3 × 10 9 platelets/kg of LP or CPP. Primary outcome measures were change in DOGiBAT score, platelet count, need for additional red cell transfusion and all-cause mortality.

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mentioning

confidence: 99%

Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial

Goggs

Brainard

LeVine

et al. 2020

Veterinary Internal Medicne

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“…Proinflammatory cytokines are produced by platelets and leukocytes in platelet products, and bacterial contamination is mainly caused by skin bacteria during phlebotomy [37,38]. The risk of these two factors increases during platelet storage [39]. These side effects can be minimized in lyophilized platelets because unlike fresh platelets, lyophilized platelets undergo several washing processes to remove inflammatory substances in plasma, and infectious agents can be eliminated through radiation sterilization after lyophilization.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent effect of canine lyophilized platelet on an in vitro hemodilution model

Kim

Han

2023

BMC Vet Res

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The transfusion of stored platelets has emerged as an efficient method for treating dogs with thrombocytopenia. However, the availability of fresh platelets is limited in veterinary medicine due to demanding storage conditions. Lyophilized platelets have long shelf lives and can be easily stored, increasing their accessibility for thrombocytopenic dogs. Due to the lack of research and information on the dose effect, canine lyophilized platelets are used at a clinical dosage without research-based evidence. This study was to evaluate the dose effect of lyophilized canine platelets on blood coagulability. Three different concentrations of lyophilized canine platelets were added to in vitro hemodilution blood model, increasing the platelet count by 25, 50, and 100 × 106/ml and coagulation profiles were analyzed. The coagulability was evaluated via the plasma fibrinogen concentration, coagulation time, thromboelastography (TEG), and platelet function analyzer (PFA). Higher concentrations of lyophilized platelets showed dose-dependent association with decreased aPTT and R-time of TEG and increased alpha angle and MA of TEG. These results showed the potential that the higher dose of canine lyophilized platelets better improve blood coagulability than the standard dose and provided the basis for further safety and clinical studies.

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Transfusion Medicine

Yagi¹,

Spromberg²

2018

Veterinary Technician's Manual for Small Animal Emergency and Critical Care

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Platelet Products

Cited by 4 publications

References 66 publications

Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial

Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial

Dose-dependent effect of canine lyophilized platelet on an in vitro hemodilution model

Transfusion Medicine

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