Platelet Phospholipids Decrease Vascular Endothelial Permeability via a Novel Signaling Pathway Independent of cAMP/Protein Kinase A

Gainor, Jonathan P.; Morton, Christine A.; Bell, D. R.; Vincent, Peter; Minnear, Fred L.

doi:10.1111/j.1749-6632.2000.tb06569.x

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2002

2005

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“…11 Pertussis toxin has been shown to attenuate LPA-induced decreases in endothelial permeability. 13,38 We found that LPA increased the transcellular resistance of corneal endothelial and epithelial cells in a dose-dependent manner, whereas S1P only increased endothelial cell resistance. S1P did not affect corneal epithelial transcellular resistance, even at high concentrations.…”

Section: Discussionmentioning

confidence: 73%

LPA and S1P Increase Corneal Epithelial and Endothelial Cell Transcellular Resistance

Yin¹,

Watsky²

2005

Invest. Ophthalmol. Vis. Sci.

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LPA increases transcellular resistance across cultured rabbit corneal epithelial and endothelial cell monolayers, and the effect is mediated through the LPA(1) receptor and signaled through Galpha(i/o). S1P-stimulated increases in endothelial resistance are also signaled through Galpha(i/o). Both LPA and S1P prevented increased transcellular permeabilities induced by PMA, and increased actin stress fiber formation in epithelial and endothelial cells.

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Section: Discussionmentioning

confidence: 73%