Platelet peripheral-type benzodiazepine receptor in major depression

Weizman, Abraham; Burgin, Ruth; Harel, Yermi; Karp, Leon; Gavish, Moshe

doi:10.1016/0165-0327(94)00098-t

Cited by 31 publications

(12 citation statements)

References 20 publications

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“…According to previous studies, PBR densities vary considerably even in control groups, for example, the B max values for control groups were reported 4327± 1850 fmol/mg protein (Johnson et al 1998), 3106± 1986 fmol/mg protein (Weizman et al 1993), or 2557± 937 fmol/mg protein (Weizman et al 1995). We do not know whether this is due to differences in experimental methods or individual differences.…”

Section: Discussionmentioning

confidence: 67%

Peripheral-type benzodiazepine receptors on platelets are correlated with the degrees of anxiety in normal human subjects

et al. 2002

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Section: Discussionmentioning

confidence: 67%

Peripheral-type benzodiazepine receptors on platelets are correlated with the degrees of anxiety in normal human subjects

et al. 2002

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“…Thus, a further study with a larger sample size is necessary to con®rm the results of present study. It has been reported that no differences existed in the platelet BZRP density or in the dissociation constant of the receptor between untreated depressed patients and the normal controls [Weizman et al, 1995]. However, long-term treatment with antidepressants downregulated the adrenal BZRP, upregulated the hepatic BZRP [Weizman et al, 1993], and reversed the olfactory bulbectomy-induced decreases in splenic BZRP [Dennis et al, 1995] in rats.…”

Section: Statistical Proceduresmentioning

confidence: 97%

No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample

et al. 2001

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The benzodiazepine receptor (peripheral) (BZRP) plays an important role in the steroid syntheses of the adrenal glands and brain, which is possibly involved in the pathophysiology of mood disorders. We evaluated an association study between two missense variations of the BZRP gene and mood disorders in a Japanese sample. However, no statistically significant associations with either bipolar disorders or depressive disorders were observed in the allele frequencies, genotype counts, or haplotype distributions for the two variations, although the present sample size had a moderate power (0.46-0.86). These results do not suggest that the BZRP gene plays a role in the genetic predisposition of affective disorders.

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“…Indeed, upregulation of PBR was demonstrated in healthy subjects after exposure to acute stress, while downregulation is a consistent finding during chronic stressful conditions [Gavish et al, 1992;Drugan, 1996]. A decrease in PBR has also been demonstrated in several psychiatric disorders, such as GAD [Weizman et al, 1987;Ferrarese et al, 1990;Rocca et al, 1991], GSP [Johnson et al, 1998], PD [Marazziti et al, 1994], and PTSD, but not in obsessivecompulsive disorder (OCD) [Gavish et al, 1996] or major depression [Weizman et al, 1995]. In our present study, the G/ G genotype was significantly more frequent in the PD subjects than in the control subjects.…”

Section: Discussionmentioning

confidence: 93%

Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder

Nakamura

Yamada

Iwayama

et al. 2006

American J of Med Genetics Pt B

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Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5' region, the coding region (exons 2-4), and the 3' noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD.

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Platelet peripheral-type benzodiazepine receptor in major depression

Cited by 31 publications

References 20 publications

Peripheral-type benzodiazepine receptors on platelets are correlated with the degrees of anxiety in normal human subjects

Peripheral-type benzodiazepine receptors on platelets are correlated with the degrees of anxiety in normal human subjects

No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample

Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder

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