Platelet Peripheral-Type Benzodiazepine in Pregnancy and Lactation

Weizman, Abraham; Dagan, Efrat; Kaplan, Boris; Karp, Leon; Malmud, Suzanna; Gil-Ad, Irit; Leschiner, Svetlana; Snyder, Solomon H.; Gavish, Moshe

doi:10.1016/s0893-133x(98)00122-5

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Platelets possess sites of neurotransmitter uptake, storage and release and express multiple neurotransmitter receptors (Dean et al 1992;Andrews et al 1999;Emerson et al 1999;Fowler et al 1999;Gurguis et al 1999;Velayudhan et al 1999;Weizman et al 1999). Functional, pharmacological and biochemical studies have suggested a role of dopamine on platelet function (Daimon et al 1990;Emerson et al 1997Emerson et al , 1999.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Dopamine receptors in human platelets

Rícci

Bronzetti

Mannino

et al. 2001

Naunyn-Schmied Arch Pharmacol

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The expression of dopamine receptors by human platelets was investigated by Western blot analysis and immunocytochemical techniques using antibodies raised against dopamine D1-D5 receptor protein. The influence of dopamine D1-like and D2-like receptor agonists on adrenaline-induced platelet aggregation was also investigated. Western blot analysis revealed that platelet membranes bind anti-dopamine D3 or D5 receptor protein antibodies, but not anti-D1, D2 or D4 receptor protein antibodies. Cytospin centrifuged human platelets exposed to anti-dopamine D3 or D5 receptor protein antibodies developed a specific immune staining, whereas no positive staining was noticeable in platelets exposed to other antibodies tested. Both the D1-like receptor agonist 1-phenyl2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride (SKF 38393) and the D2-like receptor agonist 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) dose-dependently inhibited adrenaline-induced platelet aggregation. These effects were decreased respectively by the D-like and D2-like receptor antagonists R(+)-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (SCH 23390) and (-)sulpiride. The above findings indicate that human platelets express dopamine D3 and D5 receptors probably involved in the regulation of platelet function.

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