Platelet parameters in Chinese older adults with metabolic syndrome

Abstract

<jats:p>Purpose: We aimed to examine the associations of platelet parameters with the presence of metabolic syndrome in community-dwelling older Chinese adults. </jats:p> <jats:p>Methods: Study sample was from the Weitang Geriatric Diseases Study, which included 4338 individuals aged 60 years or above. The mean age of the participants was 68 years. Metabolic syndrome was defined based on the Adult Treatment Panel Ⅲ criteria. Platelet parameters were assessed using an automated hematology analyzer. Multiple logistic regression models were fitted to examine relationships between the platelet parameters and the presence of metabolic syndrome after adjusting for potential confounders. </jats:p> <jats:p>Results: The adjusted odds ratio (95% confidence interval) of metabolic syndrome for the highest quartile of platelet parameters (platelet count, mean platelet volume, plateletcrit, platelet distribution width, platelet larger cell ratio), when compared to the lowest quartile were 1.32 (1.06, 1.64), 1.00 (0.81, 1.24), 1.37 (1.10, 1.71),1.45 (1.14, 1.83), 1.11 (0.89, 1.39), respectively. Hypertension and diabetes modified the relationship between platelet distribution width and metabolic syndrome with the associations being significant in hypertensive and non-diabetic groups. The levels of platelet distribution width increased with the risk of metabolic syndrome in men but not in women. </jats:p> <jats:p>Conclusion: The levels of platelet count, plateletcrit and platelet distribution width increased in older adults with metabolic syndrome, suggesting that these parameters may be useful biomarkers for further risk appraisal of metabolic syndrome in aged population.</jats:p>

The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus

“…In addition, some studies did not find that having MetS was associated with a significant difference in MPV values. [ 10 , 22 , 38 , 39 ] These differences across studies may be explained in part by several factors such as the selection criteria (i.e., general population or diabetic patients), diagnostic criteria for MetS, race, and age (i.e., pre-pubertal children or older adults), thus suggesting that the association between MPV and MetS deserves further scrutiny.…”

Platelet‐associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity

“…40 In this sense, 83.6% of the patients with diabetes from our cohort received specific anti-diabetic treatment, at least partially explaining the lower MPV levels that we found when compared to other obese individuals without DM. In relation to MS, several authors reported a nonsignificant association between MS and MPV, 39,41 but one of these studies found that some components of MS were associated with a higher MPV. 39 However, Park et al found that the MPV was significantly decreased in a cohort of Korean women suffering from MS, 42 and other authors have also reported similar results.…”

Hematological abnormalities and associated factors among metabolic syndrome patients at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia

“…Hematological markers are thought to be related to IR, which is regarded to be a key component of MetS [ 25 ]. Insulin resistance-induced vascular dysfunction may lead to a decreased production of prostacyclin and nitric oxide by the vascular endothelium, which would promote an increase in platelet activity and a subsequent production of more platelets [ 24 ]. Endothelial dysfunction in MetS is also linked to elevated leukocyte count by enhancing leukocyte differentiation [ 26 ].…”