Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients

Turki, Amin T.; Lamm, Wolfgang; Schmitt, Christoph; Bayraktar, Evren; Alashkar, Ferras; Metzenmacher, Martin; Wohlfarth, Philipp; Beelen, Dietrich; Liebregts, Tobias

doi:10.1007/s00277-018-3538-8

Cited by 12 publications

(8 citation statements)

References 51 publications

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“…Recently, poor graft function (defined as cytopenia due to lack of production in at least two hematologic cell lineages) and low count of platelets have been demonstrated to be important predictors of mortality in allo-HCT patients admitted to the ICU [ 31 ]. In the original work of Bayraktar et al, thrombocytopenia (defined as platelets count < 50,000/µL) was associated with mortality in the univariate analysis [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores

Voeght

Willems

Servais

et al. 2022

Cancers

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Background. Allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients requiring intensive care unit (ICU) have high mortality rates. Methods. In the current study, we retrospectively assessed whether the Prognostic Index for Critically Ill Allogeneic Transplantation patients (PICAT) score predicted overall survival in a cohort of 111 consecutive allo-HCT recipients requiring ICU. Results. Survival rates at 30 days and 1 year after ICU admission were 57.7% and 31.5%, respectively, and were significantly associated with PICAT scores (p = 0.036). Specifically, survival at 30-day for low, intermediate, and high PICAT scores was 64.1%, 58.1%, and 31.3%, respectively. At one-year, the figures were 37.5%, 29%, and 12.5%, respectively. In multivariate analyses, high PICAT score (HR = 2.23, p = 0.008) and relapse prior to ICU admission (HR = 2.98, p = 0.0001) predicted higher mortality. We next compared the ability of the PICAT and the Sequential Organ Failure Assessment (SOFA) scores to predict mortality in our patients using c-statistics. C statistics for the PICAT and the SOFA scores were 0.5687 and 0.6777, respectively. Conclusions. This study shows that while the PICAT score is associated with early and late mortality in allo-HCT recipients requiring ICU, it is outperformed by the SOFA score to predict their risk of mortality.

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Section: Discussionmentioning

confidence: 99%

Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores

Voeght

Willems

Servais

et al. 2022

Cancers

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“…Widely recognized risk factors for AKI in cancer patients include the use of nephrotoxic drugs, angiotensin-converting enzyme inhibitors (ACEIs), chemotherapeutics, antibiotics, and nonsteroidal anti-inflammatory drugs (NSAIDs)[ 15 , 16 ]. Risk factors also include age > 65 years[ 17 ], pre-existing chronic kidney disease (CKD), and comorbid diseases (such as diabetes and cardiovascular disease)[ 17 , 18 ], sepsis[ 16 ], contrast nephropathy[ 19 ], low blood volume, preoperative dehydration[ 20 - 22 ], low serum albumin levels[ 17 , 20 ], tumor size[ 23 ], anemia[ 20 ], heavy tumor burden or extensive metastasis, extensive surgery, surgical methods, intraoperative bleeding, operation time[ 17 , 24 - 28 ], and urinary tract obstruction[ 29 ] (Table 1 ).…”

Section: Risk Factors For Tumor-related Akimentioning

confidence: 99%

“…Hypovolemia is a common cause of AKI during the perioperative period[ 20 - 22 ]; the body fluids are redistributed, the amount of extracellular fluid decreases, and the amount of fluid in the third space increases. Limiting the amount of fluid replacement and ensuring an appropriate amount of hydration can prevent the increase in cavity pressure and organ edema caused by fluid entering the interstitial space, thereby improving the patient's prognosis.…”

Section: Preventive Measures and Treatments For Aki In Gastrointestinal Tumor Patientsmentioning

confidence: 99%

Management of acute kidney injury in gastrointestinal tumor: An overview

Su¹,

Yu²,

Shen³

et al. 2021

WJCC

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Gastrointestinal tumors remain a global health problem. Acute kidney injury (AKI) is a common complication during the treatment of gastrointestinal tumors. AKI can cause a decrease in the remission rate and an increase in mortality. In this review, we analyzed the causes and risk factors for AKI in gastrointestinal tumor patients. The possible mechanisms of AKI were divided into three groups: pretreatment, intrafraction and post-treatment causes. Treatment and prevention measures were proposed according to various factors to provide guidance to clinicians and oncologists that can reduce the incidence of AKI and improve the quality of life and survival rate of gastrointestinal tumor patients.

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“…AKI is a common comorbidity in pediatric patients following HSCT, with an incidence ranging from 11% to 84%. Of these, 5%-10% of patients may require renal replacement therapy (RRT) [8,9]. Pre-renal AKI may occur at any time during and after HSCT.…”

Section: Treatment-related Reasonsmentioning

confidence: 99%

“…Several studies focused on the risk factors for AKI in different types of cancer in patients with baseline CKD or cardiovascular disease [67], namely, anemia [9,46,50], low serum albumin levels [46], different tumor size [68], preoperative dehydration [9,46,50], intra-operative bleeding, and operation time [50]. Independent predictors of AKI in the ICU were the simplified acute physiological score II (OR = 1.05), abdominal or pelvic cancer (OR = 2.84), nephrotoxic chemotherapy within the previous 3 months (OR = 3.84), and sepsis (OR = 2.74) [49].…”

Section: Risk Factors Preventive Measures and Treatments For Aki Inmentioning

confidence: 99%

Acute Kidney Injury in Oncology Patients

Wang

Diao

et al. 2020

J. Cancer

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With rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management. AKI may be caused by pre-renal, intrinsic renal, and post-renal reasons, as well as for combined reasons. This review summarizes the potential etiologies of AKI according to the three classifications. For each underlying cause of AKI, the cancer itself and/or cancer treatment may contribute to a patient developing AKI. Therefore, we present disease-and treatment-related factors for each cause category, with special focus on immune checkpoint inhibitors, which are being used increasingly more often. It is important for nephrology services to be knowledgeable to provide the best level of care.

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Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients

Cited by 12 publications

References 51 publications

Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores

Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores

Management of acute kidney injury in gastrointestinal tumor: An overview

Acute Kidney Injury in Oncology Patients

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