Platelet Nitric Oxide Metabolites in Migraine

Shimomura, Tokio; Murakami, Fumiyo; Kotani, Kazuo; Ikawa, Shiro; Kono, S

doi:10.1046/j.1468-2982.1999.019004218.x

Cited by 66 publications

(45 citation statements)

References 17 publications

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“…Therefore, we measured total nitrite and nitrate levels as an indicator of NO production. Similar to previous studies (D 'andrea et al 1994;Sarchielli et al 1996;Shimomura et al 1999), we found that platelet nitrite and nitrate levels were significantly higher in migraine patients during their migraine attack. Shimomura at al.…”

Section: Discussionsupporting

confidence: 92%

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Increased Nitrosative and Oxidative Stress in Platelets of Migraine Patients

Yılmaz

Sürer

İnan

et al. 2007

Tohoku J. Exp. Med.

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The molecular mechanisms of migraine have not been fully clarified yet. Increased nitrosative and oxidative stress may be associated with migraine attacks. Platelets may play an important role in migraine patients and they can reflect the lability of tissues to nitrosative/oxidative stress. In the present study, we aimed to determine the levels of nitrosative and oxidative stress markers in platelets of migraine patients during headache-free and attack periods. A total of 56 subjects (22 migraine without aura, 14 migraine with aura, and 20 age-and sex-matched healthy controls) were included in the study and nitric oxide (NO) metabolites, malondialdehyde (MDA), and thiol (SH) groups were measured in platelets. During migraine attacks, platelet levels of nitrate, nitrite and MDA were significantly higher in migraineurs than these in control subjects ( p = 0.042, p = 0.005 and p = 0.042, respectively). By contrast, during headache-free period, no statistically significant differences were found in the platelet levels of nitrate, nitrite and MDA between migraineurs and controls ( p > 0.05), although the marginal increases were detected in migraineurs. These results suggest that increased biomarkers of nitrosative and oxidative stress in platelets may be important in migraine patients, especially during attacks; increase of NO metabolites in platelets during attacks supports the opinion that NO may play a modulatory role in biological processes particularly by vasodilatation in migraine attacks. Therefore, MDA and NO metabolites may serve as useful markers to show the increased vulnerability to nitrosative and oxidative stress in migraine patients. headache; migraine; nitric oxide; oxidative stress; nitrosative stress

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Section: Discussionsupporting

confidence: 92%

“…Error bars show S.D. ), the best index of overall NO production is the total concentration of both nitrate and nitrite (Shimomura et al 1999). Therefore, we measured total nitrite and nitrate levels as an indicator of NO production.…”

Section: Discussionmentioning

confidence: 99%

Increased Nitrosative and Oxidative Stress in Platelets of Migraine Patients

Yılmaz

Sürer

İnan

et al. 2007

Tohoku J. Exp. Med.

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“…Additionally, it is suggested that intranasal hydroxocobalamin, a NO scavenger, may have a prophylactic effect in migraine [22]. Highly increased NO levels of our migraine patients during attack and interictal period as compared to the controls are in concordance with the results of the most studies [16][17][18][19][20].…”

Section: Discussionsupporting

confidence: 87%

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

et al. 2011

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Asymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 ± 7.7, 31.0 ± 6.2 lmol/L, respectively, p = 0.005) and ADMA (0.409 ± 0.028, 0.381 ± 0.044 lmol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.

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“…This increase may account for some alterations in platelet function observed in migraineurs, such as the increase in platelet content of L-arginine and the reduced responsiveness to collagen; the latter finding was first shown by D'Andrea et al [5] and later confirmed by our group [4,30]. A recent study in migraine patients confirmed the activation of NOS in platelets, especially during attacks, by demonstrating increased NO end-products compared with headache-free period [31].…”

Section: Platelets As a Model For The Study Of No Metabolismmentioning

confidence: 52%

Platelets in migraine

Sarchielli

Gallai

2001

J Headache Pain

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Modification in platelet activation and aggregation has been demonstrated in migraine patients both during and between attacks. A different pattern in the secretion of platelet products has also been observed in patients affected by migraine compared with controls. The most important variation concerns a hyposecretion of dense body products. Platelets share structural and functional analogies with monoaminergic neurons, in particular serotoninergic neurons, and have been used as a peripheral model to study monaminergic function in migraine patients. A reduced turnover of serotonin has been shown in migraine patients in the interictal period, whereas a reduced content of this monoamine was detected in patients with chronic daily headache (CDH), particularly in those with analgesic abuse. Nitric oxide metabolism was also studied in platelets of migraine patients between and during attacks. An increased activity of nitric oxide synthase (NOS), which was more accentuated during attacks, was found in these patients compared to healthy individuals. The increase in platelet NOS activity was also confirmed in CDH patients in association with a reduction of serotonin content and increased calcium levels. Variations in aggregation to different agents and secretion may not, at the moment, be indicative of similar changes in cerebral circulation of migraine patients. Its occurrence should be confirmed in samples of jugular venous blood during attacks to establish a definite link with migraine pathogenesis. Moreover changes in serotonin and NO metabolism observed in platelets of migraine patients may only indirectly suggest similar modifications in the neuronal pathways involved in inducing and maintaining head pain in migraineurs.

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Platelet Nitric Oxide Metabolites in Migraine

Cited by 66 publications

References 17 publications

Increased Nitrosative and Oxidative Stress in Platelets of Migraine Patients

Increased Nitrosative and Oxidative Stress in Platelets of Migraine Patients

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

Platelets in migraine

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