Platelet monoamine oxidase activity and headache.

Glover, Vivette; Peatfield, Richard; Zammit-Pace, R; Littlewood, Julia; Gawel, Marek; Fc, Rose; Sandler, M.

doi:10.1136/jnnp.44.9.786

Cited by 44 publications

(38 citation statements)

References 17 publications

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“…Our finding of a lower activity of platelet phenol sulphotransferase P in susceptible subjects [10] has been confirmed by Launay et al [11], whereas platelet monoamine oxidase is not lower in diet-sensitive patients [12]. Littlewood et al [13] demonstrated an inhibition of phenol sulphotransferase in vitro by red wine, consistent with the consumption in vivo of a single glass.…”

Section: Red Wine Sensitivitysupporting

confidence: 77%

“…Two pa- a Assuming a molecular weight of wine extract equal to 660 [38] tients did not develop a headache on either occasion, two patients developed a moderate headache on one occasion and none on the other, one of them after mepyramine and the other after placebo, and two further patients developed a headache on both occasions, which was worse after placebo in one and after mepyramine in the other (Table 2). By analogy with the studies of platelet monoamine oxidase undertaken by Glover et al [12], we also speculated that histamine metabolism might be impaired in the red-wine-sensitive patients. Dietary histamine is largely metabolised by diamine oxidase (DAO) in the gut wall, and traces of this can be assayed within the plasma, correlating reasonably with gut levels in experimental animals [31].…”

Section: Histamine Experimentsmentioning

confidence: 99%

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Pharmacological analysis of red-wine-induced migrainous headaches

Peatfield¹,

Fletcher

Rhodes

et al. 2003

J Headache Pain

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IntroductionCheese, chocolate and red wine are the most publicised triggers for migrainous headaches, at least in English speaking countries. Systematic surveys of patients attending the Princess Margaret Migraine Clinic at Charing Cross Hospital have established that about 18%-19% of patients report sensitivity to cheese or chocolate, and usually to both [1]. In a more recent epidemiological survey [2] the 18% of migrainous patients sensitive to all alcoholic drinks were distinguished from a further 12% sensitive only to red wine, but not to white wine or clear spirits. There was a statistically significant but by no means absolute correlation between red wine and food sensitivity, though it was extremely rare for a diet-sensitive patient to be tolerant of all forms of alcohol [2]. We also found very few patients with tension or cluster headache to be sensitive to food or Abstract We describe a series of experiments designed to investigate the mechanisms by which headaches can be triggered by red wine in a small minority of migraine patients. Some red wines are particularly potent releasers of serotonin from platelet stores, but these are no more effective as triggers of headache in sensitive patients. Both the selective 5-HT 2A antagonist ketanserin and the non-selective 5-HT2ABC antagonist pizotifen blocked the majority of headaches, and we then thought the antihistamine properties of these two drugs might be important. In a third experiment, however, the H1 antagonist mepyramine did not convincingly antagonise the response to red wine. Plasma levels of the enzyme diamine oxidase, which metabolises histamine, were lower in all migraine patients, whether or not they were sensitive to red wine. The results reported here do not permit making firm conclusions; nevertheless it seems that different pharmacological receptors may be responsible in different patients.

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Section: Red Wine Sensitivitysupporting

confidence: 77%

Section: Histamine Experimentsmentioning

confidence: 99%

Pharmacological analysis of red-wine-induced migrainous headaches

Peatfield¹,

Fletcher

Rhodes

et al. 2003

J Headache Pain

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“…Several investigators have reported a 20-40% decrease in platelet MAOB activity in subjects with migraine headaches [3,4,22,41,44,49], as well as decreases in MAOB activity during the course of an acute episode [16,44]. Such findings, however, remain controversial with some authors reporting decreases only in a subpopulation of migraine patients [15], and others reporting 'increases' [9] or 'no change' [35,46]. Differences may relate to factors including cigarette smoking [10,49] and hormonal status [9,47] that independently affect MAO levels and have not been accounted for in most studies.…”

Section: Discussionmentioning

confidence: 81%

Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice

Scremin

Holschneider

Chen³

et al. 1999

Brain Research

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Cerebral cortical blood flow (CBF) was measured autoradiographically in conscious mice without the monoamine oxidase B (MAOB) gene (KO, n = 11) and the corresponding wild-type animals (WILD, n = 11). Subgroups of animals of each genotype received a continuous intravenous infusion over 30 min of phenylethylamine (PEA), an endogenous substrate of MAOB, (8 nmol g −1 min −1 in normal saline at a volume rate of 0.11 μl g −1 min −1 ) or saline at the same volume rate. Maps of relative CBF distribution showed predominance of midline motor and sensory area CBF in KO mice over WILD mice that received saline. PEA enhanced CBF in lateral frontal and piriform cortex in both KO and WILD mice. These changes may reflect a differential activation due to chronic and acute PEA elevations on motor and olfactory function, as well as on the anxiogenic effects of this amine. In addition to its effects on regional CBF distribution, PEA decreased CBF globally in KO mice (range −31% to −41% decrease from control levels) with a lesser effect in WILD mice. It is concluded that MAOB may normally regulate CBF distribution and its response to blood PEA.

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“…For platelet monoamine oxidase determinations, 10 ml venous blood samples were collected in polypropylene test tubes containing 0.5 ml of 50 g/1 Na 2 EDTA. For platelet isolation, Corash's platelet isolation method modified by Glover et al (19) was applied. The sample was centrifuged at 3 20 g for 10 min and the platelet-rich plasma withdrawn and re-centrifuged at 2500 g for 15 min.…”

Section: Assaymentioning

confidence: 99%

“…There are two types of monoamine oxidase, one being a FAD containing enzyme (intracellular) located in the outer membrane of the mitochondria of many tissues such as platelets (8)(9)(10)(11)(12) and the other, a Cu 2+ and pyridoxal phosphate containing enzyme found in serum (13). It has been suggested that while tissue and serum monoamine oxidase activities manifest abnormal alterations in various disease states (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), physiological fluctuations may also be detected in normals (8,(27)(28)(29)(30). The objective of this study has been to investigate the sex and age related fluctuations of platelet and serum monoamine oxidase in healthy volunteers.…”

Section: Introductionmentioning

confidence: 99%

Age and Sex Related Alterations in Serum and Platelet Monoamine Oxidase

Veral

Alper²,

Menteş³

et al. 1997

Clinical Chemistry and Laboratory Medicine

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Summary:The process of aging presents itself with various alterations in physiological events. Although the turnover of catecholamines increases with aging, there is a lack of response to catecholamines in target tissues. One of the key enzymes in catecholamine metabolism is monoamine oxidase. It has been suggested that tissue and serum monoamine oxidase activities show pathological alterations in various diseases while physiological fluctuations can also be detected in normals. The aim of this study is to determine the sex and age related changes of platelet and serum monoamine oxidase in healthy volunteers.In this study, 75 healthy volunteers of different ages (21-80 a) and sexes (40 females, 35 males) were included. Serum and platelet monoamine oxidase determinations were performed spectrophotofluorometrically by Tufoesson's (Scand J Clin Lab Invest 1970; 26:151-4) and Kraml's (Biochem Pharmacol 1965; 14:1684-6) modified methods, respectively.While there was no significant difference in serum monoamine oxidase activities related to age and sex, platelet monoamine oxidase manifested a significant increase in females compared to males (p < 0.05) and the mean values in both sexes showed an increase with age (p < 0.001).The results of this study imply that platelet monoamine oxidase shows an age related increase which is more prominent in females.

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Platelet monoamine oxidase activity and headache.

Cited by 44 publications

References 17 publications

Pharmacological analysis of red-wine-induced migrainous headaches

Pharmacological analysis of red-wine-induced migrainous headaches

Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice

Age and Sex Related Alterations in Serum and Platelet Monoamine Oxidase

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