Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy

Chen, Hao; Luo, Xi; Huang, Qinghua; Liu, Zeming; Lyu, Meng; Chen, Dexin; Mo, Jianlan; Zhu, Daoming

doi:10.1016/j.cej.2023.146276

Cited by 6 publications

(5 citation statements)

References 56 publications

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“…demonstrated that a platelet membrane fusion liposome nanovesicle system (named TFL) loaded with type I AIE photosensitizer TBP-2. In this study, TBP-2 has the potential to increase the incidence of cuproptosis and induce the vaccine-function in tumor site ( 57 , 58 ).…”

Section: Inducers Of In Situ Icd-based Cancer Vacc...mentioning

confidence: 99%

Immunogenic cell death-based cancer vaccines: promising prospect in cancer therapy

Wang,

Ma,

Xie

et al. 2024

Front. Immunol.

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Tumor immunotherapy is a promising approach for addressing the limitations of conventional tumor treatments, such as chemotherapy and radiotherapy, which often have side effects and fail to prevent recurrence and metastasis. However, the effectiveness and sustainability of immune activation in tumor immunotherapy remain challenging. Tumor immunogenic cell death, characterized by the release of immunogenic substances, damage associated molecular patterns (DAMPs), and tumor associated antigens, from dying tumor cells (DTCs), offers a potential solution. By enhancing the immunogenicity of DTCs through the inclusion of more immunogenic antigens and stimulating factors, immunogenic cell death (ICD) based cancer vaccines can be developed as a powerful tool for immunotherapy. Integrating ICD nanoinducers into conventional treatments like chemotherapy, photodynamic therapy, photothermal therapy, sonodynamic therapy, and radiotherapy presents a novel strategy to enhance treatment efficacy and potentially improve patient outcomes. Preclinical research has identified numerous potential ICD inducers. However, effectively translating these findings into clinically relevant applications remains a critical challenge. This review aims to contribute to this endeavor by providing valuable insights into the in vitro preparation of ICD-based cancer vaccines. We explored established tools for ICD induction, followed by an exploration of personalized ICD induction strategies and vaccine designs. By sharing this knowledge, we hope to stimulate further development and advancement in the field of ICD-based cancer vaccines.

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Section: Inducers Of In Situ Icd-based Cancer Vacc...mentioning

confidence: 99%

Immunogenic cell death-based cancer vaccines: promising prospect in cancer therapy

Wang,

Ma,

Xie

et al. 2024

Front. Immunol.

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“…Different from traditional surgery, photothermal therapy is typically noninvasive or minimally invasive, causing less harm to the patient’s body than traditional surgery ( 7 , 8 ). Photothermal therapy can be combined with other treatment methods, such as chemotherapy and radiotherapy, to enhance therapeutic outcomes ( 9 – 14 ). However, its effectiveness is subject to certain limitations, such as tissue penetration and dependence on photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

Hyperosmotic cold shock mouse melanoma cells encapsulated with doxorubicin for targeted treatment of melanoma

Kong,

Wang,

Wang

et al. 2024

Front. Oncol.

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BackgroundThe primary treatment strategies for melanoma include surgical excision, chemotherapy, and radiotherapy. However, the efficacy of these treatments is often limited by drug resistance, recurrence, and severe side effects. Therefore, we aimed to develop a targeted drug delivery system capable of selectively locating tumor sites to minimize systemic toxicity and enhance therapeutic efficacy. This cell drug delivery system can also deliver chemotherapeutic drugs to the tumor microenvironment.MethodsWe treated B16F10 cells with hyperosmotic cold shock (HCS) to obtain and characterize HCS cells. We then investigated the anti-tumor effects and immune activation capabilities of these cells and explored their potential as a targeted drug delivery system.ResultsHCS cells not only maintained an intact cellular structure and tumor antigens but also exhibited high expression of the homologous melanoma-associated antigen glycoprotein 100. These cells demonstrated an exceptional capacity for loading and releasing doxorubicin, which has chemotherapeutic anti-tumor effects. HCS cells can precisely target the tumor microenvironment to minimize systemic toxicity, inducing an immune response by activating CD3+ and CD4+ T cells.ConclusionHCS cells are non-carcinogenic, with both cellular and tumor antigens intact; thus, they are suitable drug delivery carriers. Our findings highlight the potential of HCS cells for carrying doxorubicin because of their high drug-loading efficiency, effective tumor-targeting and anti-tumor effects. Therefore, our results will facilitate the development of melanoma treatments that have higher efficacy than those in the literature.

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“…PMN can target tumor tissue efficiently by P-selectin (CD62p)-CD44 binding on the platelet membrane. 18 , 19 For example, in the previous study, composite hybrid system (named PMT) was prepared by loading photosensitiser into mesoporous organosilicon nanoparticles (MON) and further modifying the platelet membrane. 12 Furthermore, Chen et al designed a copper-doped hybrid bionic nanoparticles for enhanced low-temperature photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy

Jiang,

Liao,

Tang

et al. 2024

IJN

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Introduction The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy of radiotherapy (RT). Efficient elimination of potential CSCs is crucial for enhancing the effectiveness of RT. Methods In this study, we developed a biomimetic hybrid nano-system (PMC) composed of MnCO 3 as the inner core and platelet membrane (PM) as the outer shell. By exploiting the specific recognition properties of membrane surface proteins, PMC enables precise targeting of CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO 3 NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity and eradicating CSCs. Subsequent RT effectively eliminates common tumor cells. Results Both in vitro cell experiments and in vivo animal studies demonstrate that SDT mediated by PMC synergistically enhances RT to selectively combat CSCs while inhibiting tumor growth without noticeable side effects. Discussion Our findings offer novel insights for enhancing the efficacy and safety profiles of RT.

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Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy

Cited by 6 publications

References 56 publications

Immunogenic cell death-based cancer vaccines: promising prospect in cancer therapy

Immunogenic cell death-based cancer vaccines: promising prospect in cancer therapy

Hyperosmotic cold shock mouse melanoma cells encapsulated with doxorubicin for targeted treatment of melanoma

Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy

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