Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities?

Okur, Nilüfer; Büyüktiryaki, Mehmet; Uraş, Nurdan; Öncel, Mehmet Yekta; Ertekin, Ömer; Canpolat, Fuat Emre; Oğuz, Şerife Suna

doi:10.3109/14767058.2015.1121475

Cited by 35 publications

(55 citation statements)

References 25 publications

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“…35 They showed that PMI was significantly lower in these neonatal complications, although differences in MPV were not significant. 35 Similar to Okur et al, we found that PMI in the group with more severe TTN was lower; but no significant difference was noted in MPV between the groups. Low PMI reflects platelet function, which contributes to the initiation of inflammatory cascades.…”

Section: Discussionmentioning

confidence: 94%

“…Okur et al . reported that preterm infants with bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, retinopathy of prematurity, and sepsis had lower PMI in the early period of life compared with preterm infants without these neonatal morbidities . They showed that PMI was significantly lower in these neonatal complications, although differences in MPV were not significant .…”

Section: Discussionmentioning

confidence: 97%

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Platelet mass index and prediction of severity of transient tachypnea of the newborn

İlhan

Bor

2019

Pediatrics International

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Background Platelet mass index (PMI) is associated with platelet functionality. The aim of this study was to evaluate the role of PMI in predicting the severity of transient tachypnea of the newborn (TTN). Methods Infants with gestational age ≥37 weeks and birthweight ≥2,000 g who were given nasal intermittent mandatory ventilation for TTN ≤6 h after birth were retrospectively enrolled in this study. PMI was calculated using the following formula: PMI = platelet count × mean platelet volume/103 (fL/nL). The study infants (n = 101) were divided into two groups according to the duration of tachypnea: ≤48 h (n = 45) and >48 h (n = 56). Results The PMI and platelet count were significantly lower in the group with tachypnea duration >48 h than in the tachypnea duration ≤48 h group (P < 0.001 and P = 0.04, respectively). A negative significant correlation was noted between PMI and the duration of tachypnea (r = −0.43, P < 0.001). A PMI cut‐off of 1,562 fL/nL can predict prolonged tachypnea (>48 h) with a sensitivity of 62.5%, specificity of 68.9%, positive predictive value of 71.4%, and negative predictive value of 59.6% (area under the curve, 0.682 ± 0.053; P = 0.002). Conclusions Lower PMI and lower platelet count are associated with longer duration of tachypnea in patients with TTN.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Platelet mass index and prediction of severity of transient tachypnea of the newborn

İlhan

Bor

2019

Pediatrics International

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“…Exclusion of 68 records resulted in 30 studies being included in this review. [9][10][11][13][14][15][16] A summary of the included studies is given in ►Table 1.…”

Section: Resultsmentioning

confidence: 99%

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

Grevsen

Hviid

Hansen

et al. 2019

Semin Thromb Hemost

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Intraventricular hemorrhage (IVH) affects up to 22% of extremely low birth weight neonates. Impaired coagulation might contribute to the pathogenesis of IVH. The aims of this study were to summarize the current knowledge on the role of platelet indices in premature neonates with IVH and to provide an overview of secondary hemostasis parameters as well as fibrinolysis in premature neonates with IVH. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases PubMed, Embase, Scopus, and Web of Science were searched on March 7, 2019, without time restrictions. In total, 30 studies were included. Most studies investigated the significance of platelet counts and/or mean platelet volume (MPV). The meta-analysis showed that at day 1 of life, neither platelet count nor MPV differed significantly between neonates with or without IVH (standardized mean difference [SMD]: –0.15 × 109/L, 95% confidence interval [CI]: –0.37 to 0.07 and SMD: 0.22 fl, 95% CI: –0.07 to 0.51, respectively). However, platelet counts < 100 × 109/L were associated with an increased risk of IVH. Secondary hemostasis parameters did not differ between neonates with and without IVH. Fibrinolysis was only sparsely investigated. In conclusion, platelet counts < 100 × 109/L were associated with an increased risk of IVH in premature neonates. The impact of secondary hemostasis was only sparsely investigated but seemed to be minor, and the role of fibrinolysis in IVH in premature neonates needs further research. Whether reduced platelet function is associated with an increased risk of IVH in premature neonates remains to be investigated.

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“…Likewise, previous studies have implicated high MPV in the first postpartum hours with increased risk of necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and intravascular hemorrhage (IVH) in neonates (11,12). On the other hand, platelet mass index (PMI), calculated by multiplying platelet count by MPV, is associated with retinopathy of prematurity, NEC, and IVH (13). However, few studies report whether platelet parameters (MPV, PDW, and PMI) may reflect neonatal disease such as BPD, NEC, and IVH in a large cohort.…”

Section: Introductionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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Background: Platelets participate in many physiological and pathological functions and some platelet parameters predict adult diseases. However, few studies report whether platelet parameters may reflect neonatal disease and mortality in a large cohort.Objective: We aimed to investigate whether platelet parameters could predict bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and NICU mortality. Study Design and Methods:This retrospective cohort study examined records from 2006 to 2017 at the neonatal intensive care unit (NICU) of Fukushima Medical University Hospital. We retrospectively investigated platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) on the first day of life in preterm newborns born <32 weeks' gestation admitted to our NICU from 2006 to 2017. Receiver operating characteristic (ROC) and multiple regression analyses, along with Cox proportional hazard modeling, identified independent predictors of morbidities and mortality in preterm newborns.Results: Of 1,501 neonates admitted to our NICU, a total of 305 preterm newborns were included in this study. Gestational age, birth weight, and Apgar score were significantly lower in non-survivors than in survivors. Platelet count, PCT, PDW and PMI did not differ significantly between the two groups, whereas mean MPV in non-survivors was significantly higher than in survivors (10.5 fl vs. 10.0 fl, p = 0.001). Multivariate Cox hazard modeling showed that shorter GA [HR: 0.628, 95% CI: 0.464-0.840, p = 0.003], male sex [HR: 0.269, 95% CI: 0.113-0.640, p = 0.001], and MPV [HR: 1.469, 95% CI: 1.046-2.063, p = 0.026] independently predicted overall survival. Per receiver operating curve, an MPV threshold of 10.2 fl. MPV predicts prognosis in neonates with a sensitivity of 72.4% and a specificity of 58.6% (AUC = 0.685, 95% CI: 0.600-0.789, p = 0.001). Furthermore, multivariate analysis revealed that platelet parameters were not associated Go et al. Platelet Parameters in Neonateswith BPD and NEC, whereas small for gestational age (SGA), Apgar score at 5 min, and low PCT were associated with intraventricular hemorrhage (IVH).Conclusion: This study demonstrates that low PCT predicts IVH, and MPV ≥ 10.2 fL correlates with mortality among infants born after <32 weeks' gestation.

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Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities?

Abstract: In this study, we found that premature infants with BPD, NEC, ROP, IVH and sepsis had lower PMI levels in early postnatal life than infants without these diseases. This might be associated with the inflammatory process.

Cited by 35 publications

References 25 publications

Platelet mass index and prediction of severity of transient tachypnea of the newborn

Platelet mass index and prediction of severity of transient tachypnea of the newborn

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

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