Platelet‐Inspired Multiscaled Cytophilic Interfaces with High Specificity and Efficiency toward Point‐of‐Care Cancer Diagnosis

Liu, Xueli; Zhang, Feilong; Wang, Qian; Jun, Gao; Meng, Jing; Wang, Shutao; Yang, Zhenzhong; Jiang, Lei

doi:10.1002/smll.201401530

Cited by 25 publications

(21 citation statements)

References 44 publications

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“…As the basic structural element and functional unit, cells play key roles in various fundamental biological processes, such as the immune invading capability of red blood cells (RBCs), adhesive property of platelets to surgical sites and CTCs, and virus phagocytosis by host cells 65–72 . Inspired by these, a variety of biomimetic platforms mimicking cell morphologies or utilizing the functions of cell membranes have been exploited for CTCs isolation 73–81 …”

Section: Nature‐inspired Hierarchical Architectures For Ctcs Isolationmentioning

confidence: 99%

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Programmable materials for efficient CTCs isolation: From micro/nanotechnology to biomimicry

Hou

Liu

Zhou

2021

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Escaping from primary tumors and entering into blood flow, circulating tumor cells (CTCs) contain significant information for both the original tumors and metastasis mechanisms. CTCs detection has become an effective liquid biopsy of tumors and shows great promise in early cancer detection, disease monitoring, prognosis and personalized medicine. Despite the urgent need from clinics, CTCs isolation from blood is still a huge challenge due to their extreme rareness in blood. Well‐defined micro/nanostructures and nature‐inspired hierarchical architectures offer unique avenues to address this challenge by matching well with the special physical properties of CTCs to sort cells or forming local topographic interactions to strengthen cell adhesion, thereby improving the CTC‐isolation performance. In this review, we first summarize researches on CTCs isolation with diverse micro/nanostructured substrates, which mainly include nanomaterials, microfluidics, DNA nanostructures, micromotors and in vivo detection devices. In sequence, various CTC‐isolation biomimetic architectures, which are inspired by different natural creatures (e.g., viruses, cells, extracellular matrix [ECM], plants, and animals), have been highlighted. At last, remaining challenges and future perspectives in designing CTC‐isolation platforms for clinical applications are also discussed.

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Section: Nature‐inspired Hierarchical Architectures For Ctcs Isolationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Programmable materials for efficient CTCs isolation: From micro/nanotechnology to biomimicry

Hou

Liu

Zhou

2021

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“…Coupling with laser microdissection (LMD), this generation of the NanoVelcro chip system can subject captured CTCs to single‐CTC analysis. Other nanomaterials, such as halloysite nanotubes, have also been explored for cell capture . Using thermoresponsive nanostructured surfaces, a novel release technique using poly( N ‐isopropylacrylamide) (PIPAAm) to conjucate into the third NanoVelcro chip system was proposed by Tseng's group .…”

Section: Emerging Microfluidic Technologies For the Capture Of Ctcsmentioning

confidence: 99%

Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

Qian

Zhang

Chen

2015

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Circulating tumor cells (CTCs) escape from primary or metastatic lesions and enter into circulation, carrying significant information of cancer progression and metastasis. Capture of CTCs from the bloodstream and the characterization of these cells hold great significance for the detection, characterization, and monitoring of cancer. Despite the urgent need from clinics, it remains a major challenge to capture and retain these rare cells from human blood with high specificity and yield. Recent exciting advances in micro/nanotechnology, microfluidics, and materials science have enable versatile, robust, and efficient cell isolation and processing through the development of new micro/nanoengineered devices and biomaterials. This review provides a summary of recent progress along this direction, with a focus on emerging methods for CTC capture and processing, and their application in cancer research. Furthermore, classical as well as emerging cellular characterization methods are reviewed to reveal the role of CTCs in cancer progression and metastasis, and hypotheses are proposed in regard to the potential emerging research directions most desired in CTC-related cancer research.

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“…34 Nonetheless, current microfabrication methods for generating nanostructured-surface (i.e., chemical etching, chemical vapor deposition, electrochemical deposition, or electrospinning) are not feasible for surface coating of microparticles. 10, 12, 28, 30…”

Section: Introductionmentioning

confidence: 99%

Enhanced capture and release of circulating tumor cells using hollow glass microspheres with a nanostructured surface

Dong

Liu

et al. 2018

Nanoscale

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Self-floating hollow glass microspheres (HGMS) modified with tumor-specific antibodies have been developed for the capture of circulating tumor cells (CTCs), and have demonstrated effective cell isolation and good viability of isolated cancer cells. However, the capture efficiency decreases dramatically if the spiked cell concentration is low, possibly due to insufficient interactions between cancer cells and the HGMS surface. In order to apply HGMS-based CTC isolation to clinically relevant samples, it is desirable to create nanostructures on the surface of HGMS to enhance cell-surface interactions. Nevertheless, current microfabrication methods cannot generate nanostructured-surfaces on microspheres. The authors have developed a new HGMS with a controlled nanotopographical surface structure (NSHGMS), and demonstrated isolation and recovery of rare cancer cells. NSHGMS are achieved by applying layer-by-layer (LbL) assembly of negatively charged SiO2 nanoparticles and positively charged poly-l-arginine molecules, then sheathing the surface with an enzymatically degradable LbL film made from biotinylated alginate and poly-l-arginine, and capping with anti-EpCAM antibodies and anti-fouling PEG molecules. Compared to smooth-surfaced HGMS, NSHGMS showed shorter isolation time (20 min), enhanced capture efficiency (93.6 ± 4.9%) and lower detection limit (30 cells per mL) for commonly used cancer cell lines (MCF7, SK-BR-3, PC-3, A549 and CCRF-CEM). This NSHGMS-based CTC isolation method does not require specialized lab equipment or an external power source, and thus, can be used for the separation of targeted cells from blood or other body fluids in a resource-limited environment.

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Platelet‐Inspired Multiscaled Cytophilic Interfaces with High Specificity and Efficiency toward Point‐of‐Care Cancer Diagnosis

Cited by 25 publications

References 44 publications

Programmable materials for efficient CTCs isolation: From micro/nanotechnology to biomimicry

Programmable materials for efficient CTCs isolation: From micro/nanotechnology to biomimicry

Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

Enhanced capture and release of circulating tumor cells using hollow glass microspheres with a nanostructured surface

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