Platelet-inspired medicine for tumor therapy

Yang, Jie; Wang, Shujun; Liu, Ping; Dai, Lu; Chen, Baoan; Luan, Jianfeng; Zhou, Jiaju

doi:10.18632/oncotarget.22853

Cited by 10 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[8][9][10][11][12][13][14][15] Various cell types have been developed, including macrophages, [16][17][18] T cells, 19,20 neutrophils, 21,22 stem cells, [23][24][25][26][27] red blood cells, [28][29][30][31][32] and platelets. 33,34 Biomimetic nanomaterials show many advantages, such as high biocompatibility, longer cycle life, inherent biodegradability, natural targeting ability of cells/tissues, high drug loading, and ability to cross biological barriers. Considering the various benefits of bionic nanomaterials compared with traditional nanoparticles, this biomimetic technology has great prospects in the future.…”

Section: Introductionmentioning

confidence: 99%

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Pei¹,

Huang²,

Chen³

et al. 2020

IJN

View full text Add to dashboard Cite

Background Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance from blood and inaccurate targeting. Materials and Methods Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise delivery of drugs to tumor sites and enable a more efficient photothermal therapy (PTT) treatment. Results Mimicking the natural platelet membrane, nanoparticles containing drugs and photothermal agents were not recognized and cleared by the immune system; they could circulate in the blood for a long time and accumulate more efficiently at the tumor site, thus releasing more antitumor drugs and achieving better PTT effects. It is worth mentioning that, in this study, we found that tumors in mice treated with the platelet-mimicking nanoparticles were completely eliminated without recurrence during the observation period (up to 18 days). Conclusion This study provides a new strategy to design delivery systems of drugs or photothermal agents, whether in biotherapy or other fields.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Pei¹,

Huang²,

Chen³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…Platelet capacity to specifically interact with tumor cells suggests that platelets can act as a biomimetic drug delivery system for antitumor therapy [207,208]. Indeed, the rapidly developing field of cell-based drug carrier systems indicates platelets as smart candidates for anticancer agent delivery due to their peculiar features: (i) simple separation from blood and ready availability, (ii) long circulation time, (iii) natural selectivity towards damaged tissue and tumor microenvironment, (iv) weak antigenicity and immunogenicity [36].…”

Section: Conclusive Remarksmentioning

confidence: 99%

Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System

Dovizio¹,

Ballerini²,

Fullone³

et al. 2021

Prime Archives in Molecular Sciences

View full text Add to dashboard Cite

Platelets contribute to several types of cancer through plenty of mechanisms. Upon activation, platelets release many molecules, including growth and angiogenic factors, lipids, and extracellular vesicles, and activate numerous cell-types, including vascular and immune cells, fibroblasts, and cancer cells. Hence, platelets are a crucial component of cell-cell communication. In particular, their interaction with cancer cells can enhance their malignancy and facilitate the invasion and colonization of distant organs. These findings suggest the use of antiplatelet agents to restrain cancer development and progression. Another peculiarity of platelets is their capability to uptake proteins and transcripts from the circulation. Thus, cancer patient platelets show specific proteomic and transcriptomic expression patterns, a phenomenon called tumor-educated platelets (TEP). The Prime Archives in Molecular Sciences: 2 nd Edition 3 www.videleaf.com transcriptomic/proteomic profile of platelets can provide information for the early detection of cancer and disease monitoring. Platelet ability to interact with tumor cells and transfer their molecular cargo has been exploited to design platelet-mediated drug delivery systems to enhance the efficacy and reduce toxicity often associated with traditional chemotherapy. Platelets are extraordinary cells with many functions whose exploitation will improve cancer diagnosis and treatment.

show abstract

“…Platelet capacity to specifically interact with tumor cells suggests that platelets can act as a biomimetic drug delivery system for antitumor therapy [ 223 , 224 ]. Indeed, the rapidly developing field of cell-based drug carrier systems indicates platelets as smart candidates for anticancer agent delivery due to their peculiar features: (i) simple separation from blood and ready availability, (ii) long circulation time, (iii) natural selectivity toward damaged tissue and tumor microenvironment, and (iv) weak antigenicity and immunogenicity [ 41 ].…”

Section: Conclusive Remarksmentioning

confidence: 99%

Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System

Dovizio

Ballerini

Fullone

et al. 2020

IJMS

View full text Add to dashboard Cite

Platelets contribute to several types of cancer through plenty of mechanisms. Upon activation, platelets release many molecules, including growth and angiogenic factors, lipids, and extracellular vesicles, and activate numerous cell types, including vascular and immune cells, fibroblasts, and cancer cells. Hence, platelets are a crucial component of cell–cell communication. In particular, their interaction with cancer cells can enhance their malignancy and facilitate the invasion and colonization of distant organs. These findings suggest the use of antiplatelet agents to restrain cancer development and progression. Another peculiarity of platelets is their capability to uptake proteins and transcripts from the circulation. Thus, cancer-patient platelets show specific proteomic and transcriptomic expression patterns, a phenomenon called tumor-educated platelets (TEP). The transcriptomic/proteomic profile of platelets can provide information for the early detection of cancer and disease monitoring. Platelet ability to interact with tumor cells and transfer their molecular cargo has been exploited to design platelet-mediated drug delivery systems to enhance the efficacy and reduce toxicity often associated with traditional chemotherapy. Platelets are extraordinary cells with many functions whose exploitation will improve cancer diagnosis and treatment.

show abstract

Platelet-inspired medicine for tumor therapy

Cited by 10 publications

References 39 publications

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System

Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System

Contact Info

Product

Resources

About