Platelet indices in SGA newborns

Wasiluk, Alicja; Dąbrowska, Milena; Osada, Joanna; Jasińska, Elwira; Laudański, T; Redźko, S

doi:10.2478/v10039-011-0030-2

Cited by 19 publications

(22 citation statements)

References 17 publications

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“…Further study also confirmed these findings with more emphasis on the effect of intrauterine growth retardation on thrombopoiesis and subsequent platelet impairments. [1] In this study, we found that protein S, directly, and APTT, inversely, associated with birth weight after adjusting for GA and sex, in order to minimize the effect of prematurity.…”

Section: Discussionmentioning

confidence: 83%

“…Studies by Wasiluk et al demonstrated that platelet indices are altered by prematurity and GA. [118] Although, platelet changes in premature neonates have been already contributed to GA and birth weight, [19] these authors concluded that decreased platelet count and increased distribution width occurs in relation with low GA and dysfunction of placenta. Further study also confirmed these findings with more emphasis on the effect of intrauterine growth retardation on thrombopoiesis and subsequent platelet impairments.…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of anti-coagulation factors, pro-coagulants and fibrinolytic proteins vary with gestational age (GA) and consequently the birth weight. [12345678] Although developing of hemostatic system rarely accompanies by clinical symptoms in healthy term neonates, premature small for GA (SGA) neonates have higher morbidity and mortality rate due to their hemostatic disturbances predisposing them to hemorrhages or thrombotic disorders. [1237910]…”

Section: Introductionmentioning

confidence: 99%

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Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

et al. 2014

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Context:There are limited studies assessing the neonatal hemostatic factors in relation to birth weight.Aims:This study aims to compare the coagulation factors between three groups of neonates with different birth weight for gestational age (GA).Settings and Design:In a cross-sectional study, 74 healthy premature neonates were involved.Subjects and Methods:Serum prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin clotting time (TT), and levels of fibrinogen, anti-thrombin III, protein S and protein C were measured. Neonates were classified into three groups according to birth weight, including small, appropriate and large for gestational age (SGA, AGA, and LGA).Statistical Analysis Used:Statistical analysis was performed using SPSS software.Results:There was a significant difference in the levels of protein S (P < 0.001), protein C (P = 0.004), and values of APTT (P = 0.01) between three groups. Other coagulation factors however, did not represent a significant pattern (P > 0.05). Protein S concentration, directly (B = 0.78, P < 0.001), and APTT, inversely (B = −0.29, P = 0.03), associated with birth weight after adjustment for GA and sex.Conclusions:Despite the decrease in APTT from SGA to AGA, and LGA neonates, levels of protein S increases directly with birth weight. However, no other coagulation factors revealed an explainable pattern in relation to the state of SGA, AGA, or LGA.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

et al. 2014

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“…Wasiluk et al found significantly lower platelet counts in severe (p<5) compared to moderate (p5-10) SGA. [10,11] Van den Hof et al describe a correlation between fetal abdominal circumference and fetal platelet count. [21] Because several studies have shown that reference values of platelet count in fetuses reach adult values early in gestation, it is unlikely that this correlation is confounded by gestational age.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies on hematologic parameters in SGA neonates have been published. [7,[10][11][12][13][14][15][16] However, information about risk factors for thrombocytopenia specifically within the SGA group is scarce.…”

Section: Introductionmentioning

confidence: 99%

Early-Onset Thrombocytopenia in Small-for-Gestational-Age Neonates: A Retrospective Cohort Study

et al. 2016

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Thrombocytopenia is a common finding in small for gestational age (SGA) neonates and is thought to result from a unique pathophysiologic mechanism related to chronic intrauterine hypoxia. Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to identify risk factors for thrombocytopenia. We performed a retrospective cohort study of all consecutive SGA neonates admitted to our ward and a control group of appropriate for gestational age (AGA) neonates matched for gestational age at birth. Main outcome measures were incidence and severity of thrombocytopenia, hematological and clinical risk factors for thrombocytopenia, and bleeding. A total of 330 SGA and 330 AGA neonates were included, with a mean gestational age at birth of 32.9 ± 4 weeks. Thrombocytopenia (<150x10 were not recorded. Within the SGA group, lower gestational age at birth (p = <0.01) and erythroblastosis (p<0.01) were independently associated with a decrease in platelet count. Platelet count was positively correlated with birth weight centiles. In conclusion, early-onset thrombocytopenia is present in over 50% of SGA neonates and occurs 2.7 times as often as in AGA neonates. Thrombocytopenia is seldom severe and is independently associated with lower gestational age at birth and erythroblastosis.

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Data Mining in Establishing the Indirect Reference Intervals of Biochemical and Haematological Assays in the Paediatric Population: A Review

Nasuruddin,

Salwana,

Sarker

et al. 2023

Advances in Visual Informatics

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Platelet indices in SGA newborns

Cited by 19 publications

References 17 publications

Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

Early-Onset Thrombocytopenia in Small-for-Gestational-Age Neonates: A Retrospective Cohort Study

Data Mining in Establishing the Indirect Reference Intervals of Biochemical and Haematological Assays in the Paediatric Population: A Review

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