Platelet indices in evaluation of patients with recurrent pregnancy loss

Al-Aghbary, Abeer Abdul-Rahman; Almorish, Mohammed Abdul Wahid; Jaffar, Dikra Waheeb Mohamed; Al-Kahiry, Waiel

doi:10.4103/2305-0500.220979

Cited by 5 publications

(6 citation statements)

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“…In contrast, a study by Aynıoglu et al .as conducted on 208 patients who experienced 2 or more first trimester spontaneous abortions and 95 controls who had no abortions showed that the PLT count and PCT were significantly higher in patients with RPL than in controls [8] . Also Alaghbary et al study which was retrospectively conducted on 45 women with a history of RPL and 45 women who gave birth without RPL disagrees with our study and found that there was significant difference in PLT count in women with RPL [5] .…”

Section: Discussioncontrasting

confidence: 96%

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The Association between Platelet Indices and Unexplained Recurrent Miscarriage

Desouky

Makled

Abuelghar

et al. 2021

Evidence Based Women's Health Journal

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Introduction:Recurrent miscarriage is an important health issue. It is defined loss of three or more consecutive pregnancies. It has multifactorial causes. Platelets (PLT) are generally known as a marker for inflammation and thrombosis. Aim: This work aimed to find the association between platelet indices and recurrent unexplained miscarriage. Materials and Methods: This study was a case control study conducted at Ain Shams University Maternity Hospital (ASUMH) recruiting women from the outpatient clinic and the recurrent pregnancy loss clinic over the period from December 2018 to August 2019. Group A included 35 women with recurrent miscarriage (RM), Group B included 35 women without history of miscarriage and delivered at least once. Platelet count and indices were measured in both groups and statistical analysis was done. Results: In the current study, there was no statistically significant difference between the cases and controls as regard PLT count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW). Conclusion: Platelet indices are not useful as predictor for recurrent miscarriage.

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Section: Discussioncontrasting

confidence: 96%

“…Also, Dundar et al reported that there is elevation in PDW values in women with RPL. Alaghbary et al study found that there was significant difference in PDW in women with RPL [5] .…”

Section: Discussionmentioning

confidence: 92%

The Association between Platelet Indices and Unexplained Recurrent Miscarriage

Desouky

Makled

Abuelghar

et al. 2021

Evidence Based Women's Health Journal

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“…In line with our analysis, platelets' count and indices were meaningfully high in RPL cases compared to healthy pregnant women in the Al-Aghbary et al study (15).…”

Section: Discussionsupporting

confidence: 89%

Is there a change in platelet indices among pregnant with antiphospholipid syndrome?

2022

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Introduction: Recurrent pregnancy loss (RPL) is a common obstetrical complication, where 50% have undetermined etiology. Antiphospholipid syndrome (APL) is an autoimmune disease documented as a cause of RPL. Thrombophilia, particularly platelet abnormalities, were accredited for RPL. Objectives: The purpose of this study is to determine the change in platelets parameters; specifically, platelet count, mean platelet volume (MPV), platelet distribution width PDW, in patients suffering from RPL caused by the anti-phospholipid syndrome. Patients and Methods: Fifty women with a confirmed diagnosis of APL syndrome having a history of RPL were assigned as a study group and fifty women who gave birth without RPL were set as healthy controls were taken from al Yarmouk teaching hospitals in Baghdad. The personal data were taken by direct interview with patients, and blood samples were taken and analyzed for complete blood counts and platelets indices. Results: Both platelets count and PDW scored significant correlation with the number of pregnancy loss; Pearson's correlation coefficient was (0.74,0.59) respectively for both variables. The ROC evaluated platelets count a cutoff value of 230 ,88%,84% respective sensitivity and specificities, AUC =0.89,and P-value<0.001 respectively. As for PDW it had a cutoff value of 13.6 fl/L,88%,80% respective sensitivity and specificities, AUC=0.87,and P-value<0.001. Conclusions: Platelet indicators may aid gynecologists' in low-resource settings in predicting high-risk pregnancies deemed to suffer from RPL .

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“…RDW-SD and hematocrit showed significant differences between groups, which is in line with the study by Bıyık (20). In a study by Al-Aghbary ( 21), only parity showed a significant difference between the two groups which was in line with our study result but our study also showed a significant difference between the two groups in terms of gestational age and gravidity which was not in line with (21). Our study was shown that the missed abortion group also had a higher smoking experience than the control group had.…”

supporting

confidence: 88%

Hematolojik Parametrelerin Geçikmiş Düşük Etiyolojisindeki Rolü

Gürbüz¹,

Okçu

2021

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Aim: To investigate mean platelet volume (MPV) values and platelet (PLT) counts of normal pregnancies and patients with missed abortions to determine whether MPV and PLT counts can predict unsuccessful pregnancy particularly missed abortion. Materials and Methods:This retrospective case-control study investigated the MPV) values and PLT counts of patients with missed abortion and the control group. Among 464 cases, 238 participants with missed abortion and 226 healthy pregnant women were included. Results:The mean age of the missed abortion group was 33.50 years and the mean age of the control group was 32 years. Age showed a statistically significant difference between the two groups (p = 0.010). The missed abortion group was in the 4th week of gestation age and the control group was in the 2nd week of gestation age which showed statistically significant difference (p < 0.001). Significant differences between the two groups in gravidity (p < 0.001) and parity (p = 0.002) were observed. 39.5% of the missed abortion group had the first gravidity while 63.2% of the control group had the first gravidity. 35.7% of the missed abortion group had the second gravidity while 63.2% of the control group had the second gravidity. No parity was observed in 54.6% of the missed abortion group and in 67.3% of the control group. First parity was observed in 37.8% of the missed abortion group and 31.4% of the control group. Smoking was significantly higher in the missed abortion group (32.3%) than that in the control group (14.1%) (p < 0.001).There was a significant difference between the two groups in Red cell distribution width (RDW-SD) (p < 0.001) and in hematocrit (p = 0.032). There was no significant correlation between MPV (p = 0.155; OR = 1.097; CI = 0.966_1.247), Platelet distribution width (PDW) (p = 0.695; OR = 0.991; CI = 0.947_1.037), plateletcrit (PCT) (p= 0.468) and missed abortion. Conclusion:MPV may not be used as a screening or diagnostic test for unsuccessful pregnancies particularly missed abortion as shown in the current study.

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Platelet indices in evaluation of patients with recurrent pregnancy loss

Cited by 5 publications

References 0 publications

The Association between Platelet Indices and Unexplained Recurrent Miscarriage

The Association between Platelet Indices and Unexplained Recurrent Miscarriage

Is there a change in platelet indices among pregnant with antiphospholipid syndrome?

Hematolojik Parametrelerin Geçikmiş Düşük Etiyolojisindeki Rolü

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