Platelet Indices for Predicting Patient Outcomes in Post-Neurosurgical Meningitis

Abstract

Background: Platelet volume indices (PVIs) are inexpensive and readily available parameters in intensive care units (ICUs). However, their association with mortality has never been investigated in the post-neurosurgical meningitis (PNM). Objectives: This study was designed to investigate the association of PVIs with mortality in PNM patients. Methods: This retrospective study was conducted in the adult patients undergone various neurosurgical procedures in a neurosurgery department at a tertiary educational medical center in Tehran from 2016 to 2017. In this study, platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet count were measured on ICU admission. Results: A total of 37 patients were included, 18 of whom survived (mortality rate: 50%). PDW and MPV values were significantly higher in non-survivors than in survivors. In non-survivor patients, platelet count was significantly lower and PDW was higher at diagnosis and discharge when compared to on admission. Also, there was no significant linear correlation between Charlson comorbidity index (CCI) and platelet indices. The means of these parameters showed no significant differences in CCI categories between the two patient subgroups. Conclusions: The obtained data revealed that the high levels of MPV and PDW in PNM are not associated with the increased risk of mortality, whereas the decrease in plateletcrit was not associated with increased risk of mortality.

Impact of Red Cell and Platelet Distribution Width in Patients of Medical Intensive Care Unit

“…Zhan et al 31 noted in a study that increase in PDW was noted in fatal cases when compared with the survivors. Simani et al 32 observed higher PDW values in patients who had a fatal course when suffering from post-neurosurgical meningitis when compared with the survivors. Gao et al 33 in a study on patients with septic shock noted higher chances of death in patients with increased PDW.…”

Platelet indices as prognostic markers in the critically ill patient

“…Large platelets have increased platelet activity as they produce large amounts of thromboxane A2. 5 As platelet indices are inexpensive and relatively less time consuming, 6 they can be ideal for use as prognostic factors for critically ill patients in a country like India, where healthcare resources are scarce. The present research was intended to study platelet indices as prognostic factors in critically ill patients at a tertiary care hospital.…”

“…4 Numerous blood count parameters such as packed cell volume, PCT count, and total leucocyte count are used in various scoring systems for intensive care patients, such as multiple organ dysfunction scores, sequential organ failure assessment scores, and logistic organ dysfunction scores. 5 Lately, numerous studies 2,[5][6][7] have suggested an association between these indices and platelet activation, which is an independent risk fac-Contributions: AJY, literature search, data acquisition and statistical analysis; manuscript editing and review; SMA, definition of intellectual content; AJY and SMA, study concepts and design, clinical and experimental studies, manuscript preparation, guarantors.…”