Platelet Indices as Predictors of Diabetic Kidney Disease in Type 2 Diabetes Mellitus

Elsayed, Ahmed; Bazeed, Mahmoud; Nassar, Youssef; Hamdy, Nesreen

doi:10.21608/ijma.2023.184143.1586

International Journal of Medical Arts

2023

DOI: 10.21608/ijma.2023.184143.1586

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Platelet Indices as Predictors of Diabetic Kidney Disease in Type 2 Diabetes Mellitus

Ahmed Elsayed¹,

Mahmoud Bazeed

Youssef Nassar

et al.

Abstract: Article informationBackground: Type 2 diabetes [T2D] is characterized as a complicated and varied group of metabolic conditions. The disorder's defining feature is increased blood sugar level brought on by a malfunction in insulin action and/or secretion. Aim of the Work:To evaluate Platelet indices as predictive biomarkers for diabetic nephropathy in diabetes type 2.

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Dysregulated coagulation system links to inflammation in diabetic kidney disease

Xiao,

Tang,

Luan

et al. 2023

Front. Clin. Diabetes Healthc.

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Diabetic kidney disease (DKD) is a significant contributor to end-stage renal disease worldwide. Despite extensive research, the exact mechanisms responsible for its development remain incompletely understood. Notably, patients with diabetes and impaired kidney function exhibit a hypercoagulable state characterized by elevated levels of coagulation molecules in their plasma. Recent studies propose that coagulation molecules such as thrombin, fibrinogen, and platelets are interconnected with the complement system, giving rise to an inflammatory response that potentially accelerates the progression of DKD. Remarkably, investigations have shown that inhibiting the coagulation system may protect the kidneys in various animal models and clinical trials, suggesting that these systems could serve as promising therapeutic targets for DKD. This review aims to shed light on the underlying connections between coagulation and complement systems and their involvement in the advancement of DKD.

show abstract

Dysregulated coagulation system links to inflammation in diabetic kidney disease

Xiao,

Tang,

Luan

et al. 2023

Front. Clin. Diabetes Healthc.

View full text Add to dashboard Cite

show abstract

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Platelet Indices as Predictors of Diabetic Kidney Disease in Type 2 Diabetes Mellitus

Cited by 1 publication

References 20 publications

Dysregulated coagulation system links to inflammation in diabetic kidney disease

Dysregulated coagulation system links to inflammation in diabetic kidney disease

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