Platelet Indices as a marker for early prediction of erectile dysfunction in diabetic patients

Taieb, Moustafa A El; Hegazy, Eisa M.; Maklad, Salah; Khairy, Reham

doi:10.1111/and.13163

Cited by 14 publications

(18 citation statements)

References 28 publications

(28 reference statements)

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“…Studies demonstrated that over 95% of cases could be successfully treated. 7,8 ED is a private issue. Many men feel embarrassed to disclose and discuss the problem with their physician, or even their life-partner.⁹ There were currently lack of study have been done on ED in patients with DM.…”

mentioning

confidence: 99%

Epidemiology of erectile dysfunction in men with diabetes mellitus: a study in a primary health care center in Indonesia

Tridiantari¹,

Saraswati

Udiyono

2020

Med J Indones

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BACKGROUND Diabetes mellitus (DM) is one of the factors causing erectile dysfunction (ED) and may affect a person's quality of life. This study was aimed to describe the epidemiology of ED in men with DM in a primary health care. METHODS The study used a cross-sectional study design conducted from January to March 2017 at the Tlogosari Kulon Health Center, Semarang. There were 122 diabetic men who were all included in the study. The data were collected using interviewerassisted questionnaires. The status of ED was measured by the erectile dysfunction intensity scale adapted to the International Index of Erectile Function. RESULTS The results showed that the prevalence of diabetic men with ED was 84.4%. Most men with ED had age of ≥46 years (91.0%), experienced work stress (88.5%), had low physical activity (93.1%), had obesity (88.0%) of which 86.3% had central obesity, smoking (84.6%), had DM >5 years (91.2%), and took antihypertensive drugs (90.0%). The fasting blood glucose level of respondents ≥126 mg/dl was 86.0%, and 91.7% had sexual desire disorder. The duration of DM and aging are contributing factors of ED in males with DM, with a p-value of 0.016 and 0.013, respectively. CONCLUSIONS The prevalence of ED in primary health care is still high, and the determining factors were the duration of DM and aging. Public health centers are advised to undertake health promotion on the prevention of factors that can lead to sexual dysfunction in males with DM.

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confidence: 99%

Epidemiology of erectile dysfunction in men with diabetes mellitus: a study in a primary health care center in Indonesia

Tridiantari¹,

Saraswati

Udiyono

2020

Med J Indones

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“…Of the remaining 20 articles, 6 were excluded with different reasons, which included unable to obtain the related data distribution in cases and controls, data not qualified (controls having ED). Finally, the remaining 14 studies (Akbas et al, ; Aldemir et al, ; Aldemir et al, ; Bayraktar & Albayrak, ; Ciftci et al, ; Ciftci et al, ; El Taieb, Hegazy, Maklad, & Khairy, ; Guo et al, ; Guo et al, ; La Vignera et al, ; Otunctemur et al, ; Sambel et al, ; Senturk et al, ; Wang et al, ) were enrolled in our systematic review and meta‐analysis, all of which were identified as case–control studies. No further articles were identified for inclusion through the repeated cited reference screening.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies reporting the PLT levels in ED (1580 subjects) and non‐ED cases (977 subjects) were included in the meta‐analysis (Akbas et al, ; Aldemir et al, ; Aldemir et al, ; Bayraktar & Albayrak, ; Ciftci et al, ; Ciftci et al, ; El Taieb et al, ; Guo et al, ; Guo et al, ; Otunctemur et al, ; Sambel et al, ; Senturk et al, ; Wang et al, ). The pooled SMD indicated that individuals with ED had about 0.215 k/μl higher of PLT levels than those without ED (SMD [95% CI] = 0.215 [0.133–0.297], p = 0.000), with severe heterogeneity existed ( I 2 = 90.1%).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen articles (Aldemir et al, ; Aldemir et al, ; Bayraktar & Albayrak, ; Ciftci et al, ; Ciftci et al, ; El Taieb et al, ; Guo et al, ; Guo et al, ; Otunctemur et al, ; Sambel et al, ; Senturk et al, ; Wang et al, ) with data consisting of MPV level in individuals with ED (1595 subjects) vs. without ED (967 subjects) were included in the final data analysis. The overall SMD indicated that cases with ED had higher MPV level than those in controls (overall, SMD [95% CI] = 0.651 [0.567–0.735], p = 0.000), still with severe heterogeneity (92.5%).…”

Section: Resultsmentioning

confidence: 99%

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Platelet indices and erectile dysfunction: A systematic review and meta‐analysis

Yang

Muzepper

2019

Andrologia

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Elevated platelet levels have been postulated to be associated with cardiovascular diseases, conditions closely linked to erectile dysfunction (ED). The current systematic review and meta‐analysis was performed to assess the platelet indices, which including platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with ED compared to controls in an attempt to clarify the possible role of platelet indices in the pathogenesis of ED. We initially screened the candidate studies observing the possible association between platelet indices and ED following literature search of database Cochrane Library, PubMed, EMBASE and MEDLINE and therefore included the studies based on the pre‐defined inclusion and exclusion criteria. Two independent investigators extracted the related information on article data and outcome measures from the qualified studies, and a meta‐analysis was therefore performed using Stata 12.0 software. Subgroup analyses were conducted by the different ED aetiology obtained from the eligible studies. The standard mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were applied to estimate the outcome measures. A total of 14 articles were qualified in our meta‐analysis with a total of 1595 cases and 987 controls included. Pooled estimate was in favour of increased MPV levels in subjects with ED with a SMD of 0.651 fl, 95% CI 0.567–0.735, p = 0.000. Subgroup analysis showed that vasculogenic ED had a higher MPV levels than controls as well (SMD [95% CI] = 1.026 [0.823–1.228], p = 0.000). However, pooled analysis based on PLT and PDW levels has produced inconsistent results and not strong evidence on platelet level and ED correlation. In conclusion, vasculogenic ED patients had a higher MPV level in our study. However, the results need further interpretation with caution and more high‐quality studies are warranted.

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“…They also established an MPV cut-off of 9.65 fl for arterial ED diagnosis, with a specificity of 91.7% [33]. Conversely, a study conducted on 30 diabetic patients with ED did not find any difference between the different vasculogenic ED subtypes, thus suggesting that the increase in MPV in diabetic patients is correlated with vasculogenic ED regardless of the type of dysfunction (arterial, venous, or mixed) [34].…”

Section: Mean Platelet Volume and Erectile Dysfunctionmentioning

confidence: 99%

Mean Platelet Volume as a Marker of Vasculogenic Erectile Dysfunction and Future Cardiovascular Risk

Crafa

Condorelli

Mongioì

et al. 2020

JCM

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Cardiovascular diseases are the main cause of mortality in the Western population, so the attempt to find a marker capable of predicting their early onset is not surprising. It is known that arteriogenic erectile dysfunction (ED) precedes the onset of a major coronary event by several years. However, a marker that is able to early identify those patients who should undergo further diagnostic investigations is, to date, missing. Recent research on this topic has focused on the role of the mean platelet volume (MPV), a marker of platelet activity that is high in most vascular diseases, such as coronary artery disease (CAD), stroke, peripheral artery disease (PAD), and ED. The basic pathophysiological mechanism of all these clinical conditions is atherosclerosis. Platelets play a central role in amplifying this process both indirectly by stimulating endothelial cells to produce inflammatory cytokines and chemokines, and directly through the expression of membrane receptors and the release of molecules that contribute to the formation of atherosclerotic plaque. The objective of this review is to critically analyze the evidence on the role of MPV in predicting the diagnosis and severity of vasculogenic ED and the possibility of using this simple marker as a first step to start a diagnostic process aimed at assessing the cardiovascular risk in these patients.

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Platelet Indices as a marker for early prediction of erectile dysfunction in diabetic patients

Cited by 14 publications

References 28 publications

Epidemiology of erectile dysfunction in men with diabetes mellitus: a study in a primary health care center in Indonesia

Epidemiology of erectile dysfunction in men with diabetes mellitus: a study in a primary health care center in Indonesia

Platelet indices and erectile dysfunction: A systematic review and meta‐analysis

Mean Platelet Volume as a Marker of Vasculogenic Erectile Dysfunction and Future Cardiovascular Risk

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