Platelet immune complex interaction in pathogenesis of Kawasaki disease and childhood polyarteritis.

Levin, Mike; Holland, Phillip; Nokes, Timothy J.; Novelli, Vas; Mola, M.; Levinsky, Roland J.; Dillon, Michael J.; Barratt, T. M.; Marshall, W. C.

doi:10.1136/bmj.290.6480.1456

Cited by 76 publications

(41 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased levels of serum IgA-, IgG-, and IgE-containing circulating immune complexes (CIC) have also been found during the acute phase of KD (19,23,24), with up to 68% of CIC containing IgG and 85% containing IgA (25). Ohshio and colleagues similarly demonstrated elevated levels of IgA CIC with higher levels at 11-23 d of illness compared with Ͻ10 d of illness (26).…”

mentioning

confidence: 78%

Surface and Cytoplasmic Immunoglobulin Expression in Circulating B-Lymphocytes in Acute Kawasaki Disease

et al. 2001

View full text Add to dashboard Cite

mentioning

confidence: 78%

Surface and Cytoplasmic Immunoglobulin Expression in Circulating B-Lymphocytes in Acute Kawasaki Disease

et al. 2001

View full text Add to dashboard Cite

“…Not only IgG-CIC but also IgA-CIC by precipitation test with polyethylene glycol have been reported (22). High levels of IgA-CIC have been detected in necrotizing vasculitis, allergic vasculitis, Henoch-Schonlein pur pura, liver diseases and other diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The cause of the increase in IgA-CIC in Kawasaki disease is unknown. Levin et al (22) speculated that the initial febrile phase is followed by immune complex vas culitis that occurs when antibodies to an initiating agent appear in the circulation. The levels of IgA-CIC in the samples which were obtained between 11 days and 23 days after the onset were significantly higher than those which were obtained within 10 days after the onset.…”

Section: Discussionmentioning

confidence: 99%

High Levels of IgA‐Containing Circulating Immune Complex and Secretory IgA in Kawasaki Disease

Ohshio¹,

Furukawa²,

Khine³

et al. 1987

Microbiology and Immunology

View full text Add to dashboard Cite

Sera of patients with Kawasaki disease were studied for the levels of IgA-containing (C3-fixing) circulating immune complexes (IgA-CIC), IgG-contain ing (IgG-)CIC, total IgA, secretory IgA, and complement component (C3) by means of enzyme-linked immunosorbent assays or single radial immunodiffusion methods. There was significantly high level of IgA-CIC, but not IgG-CIC. The levels of total IgA, secretory IgA, and C3 were significantly elevated. Significantly high levels of secretory IgA were found in 22 (51 %) of 43 patients.

show abstract

“…ICs, detected by precipitation with polyethylene glycol, also appeared in the circulation as the platelet count increased. Platelets can be activated by many different stimuli, including contact with subendothelial tissues, ICs that bind to Fc receptors on the platelet, platelet-activating factors released from leukocytes, and several toxins or enzymes released by bacteria and viruses (31,32). Cochrane et al (33) studied the role of platelets in a rabbit model of serum sickness vasculitis, which was similar to the vasculitis of KD where coronary arteries were affected.…”

Section: Discussionmentioning

confidence: 99%

“…Cochrane et al (33) studied the role of platelets in a rabbit model of serum sickness vasculitis, which was similar to the vasculitis of KD where coronary arteries were affected. The platelet IC interaction in pathogenesis of KD was also studied (31,32). Thrombocytosis occurred with a peak usually in the third to fourth week after the onset of KD (34).…”

Section: Discussionmentioning

confidence: 99%

A Swine Model of Horse Serum-Induced Coronary Vasculitis: An Implication for Kawasaki Disease

et al. 2004

View full text Add to dashboard Cite

An attempt was made to induce immune complex vasculitis by horse serum (HS) infusions in piglets, hoping to produce experimental coronary artery lesions that mimic Kawasaki disease. A total of 21 purebred male piglets of 1.5, 2.5, and 3 mo were divided into HS (n ϭ 14) and control, normal saline (NS; n ϭ 7) groups. In seven piglets, 5 mL/kg of HS was infused, then repeated with 10 mL/kg 10 d later. In another seven piglets, 10 mL/kg of HS was infused three times at 5-d intervals. In three piglets in the control group, 5 and 10 mL/kg of NS was infused at 10-d intervals. In another four piglets of the control group, 10 mL/kg of NS was infused three times at 5-d intervals. Twodimensional echocardiographic examinations for visualization and measurement of the coronary arteries were done before and after infusions at 4-to 5-d interval. Hematology examination showed that white blood cells and platelets decreased, then increased. The animals were killed at 14 -60 d after the first infusion of HS or NS, for histopathologic and immunohistochemical studies. All HS groups developed skin rashes and echocardiographic evidence of coronary artery dilation and histopathologic changes of vasculitis. None in the NS group developed vasculitis. The main changes of the coronary vasculitis were intimal proliferation, smooth muscle cell necrosis, and vacuolization changes. Those that received three HS infusions developed more skin rashes than those that received two infusions. It is concluded that piglets may serve as an experimental model for immune complex vasculitis involving the coronary arteries with skin rashes mimicking Kawasaki disease. Kawasaki disease (KD), an acute self-limiting systemic vasculitis of unknown origin, has become a leading cause of acquired heart disease other than rheumatic heart disease in many developed countries (1-3). Coronary artery lesions (CALs) with aneurysmal dilation, thrombosis, and/or stenosis, leading to myocardial infarction and death, have been recognized as the most severe complication (4, 5). Circulating immune complexes (ICs), triggered by infectious agents, bacteria, or viral or other unknown cause, have been detected in the early phase of KD, implicating that immunopathologic mechanisms might be involved in the pathogenesis of vasculitis in KD (6 -10). Attempts to produce coronary vasculitis have been made in mice, weanling rabbits, and guinea pigs by injecting infectious agents, foreign proteins, and Lactobacillus casei cell walls (11-15). Coronary arteritis was induced in weanling rabbits by injecting horse serum (HS) (16). Swine is a unique and promising animal for biomedical research, especially in the field of cardiovascular diseases (17, 18). IC coronary vasculitis, however, was never produced in swine. We tried, therefore, to induce coronary vasculitis in piglets, hoping that CAL mimicking KD could be produced. This study was designed to observe the skin and systemic reactions and hematologic changes, measure the coronary artery diameters by echocardiography, and examine the histop...

show abstract

Platelet immune complex interaction in pathogenesis of Kawasaki disease and childhood polyarteritis.

Cited by 76 publications

References 29 publications

Surface and Cytoplasmic Immunoglobulin Expression in Circulating B-Lymphocytes in Acute Kawasaki Disease

Surface and Cytoplasmic Immunoglobulin Expression in Circulating B-Lymphocytes in Acute Kawasaki Disease

High Levels of IgA‐Containing Circulating Immune Complex and Secretory IgA in Kawasaki Disease

A Swine Model of Horse Serum-Induced Coronary Vasculitis: An Implication for Kawasaki Disease

Contact Info

Product

Resources

About