Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss

Rudack, Claudia; Langer, Claus; Junker, Ralf

doi:10.1016/j.heares.2004.01.002

Cited by 28 publications

(42 citation statements)

References 46 publications

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“…Our results are consistent with the results of others on this subject [Capaccio et al, 2007;Görur et al, 2005;Rudack et al, 2004].…”

Section: Discussionsupporting

confidence: 94%

“…Consistent with other researchers in this field [Capaccio et al, 2007;Rudack et al, 2004Rudack et al, , 2006Suckfüll, 2002], the lipidemia profile shows a slight trend to a positive relationship between acquired cardiovascular risk factors and SSHL. This profile supports our hypothesis of the potential relation between classical cardiovascular and neurovascular risks factors and SSHL.…”

Section: Discussionsupporting

confidence: 91%

“…However, in our study, it is less than 40 years. Regarding the patients who tested positive and the possible negative prognosis of the disease, Rudack et al [2004] did not find a positive association.…”

Section: Discussionmentioning

confidence: 72%

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Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

et al. 2008

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Introduction: Sudden sensorineural hearing loss (SSHL) has been proposed as a symptom of underlying vascular problems. The purpose of this work is to evaluate the genetic and acquired risk factors. Methods: Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated. Additional assessments of personal and familial history risk factors for vascular disorders were performed in each patient. Results: Thrombophilia studies did not demonstrate statistically relevant differences between the patients and control group. However, lipidemia profile and directed personal and familial histories showed positive trends for SSHL. Conclusion: The lack of clear relationships between SSHL and other vascular risk factors suggests multicausality as a predominant disease profile. Although preliminary results point at a vascular involvement in SSHL, a long-term prospective study is necessary to demonstrate that SSHL represents an early vascular symptom.

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“…Our results are consistent with the results of others on this subject [Capaccio et al, 2007;Görur et al, 2005;Rudack et al, 2004].…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

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Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

et al. 2008

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“…We confirmed a previous observation made by Rudack et al [2004] who also showed no differences between SSNHL patients and controls in the frequency of T alleles of the MTHFR C677T polymorphism. However, a recent study by Capaccio et al [2005] demonstrated a significant positive association between the C677T polymorphism (677TT) and SSNHL, compared to a control group who have had the same C677T polymorphism distribution as our control group.…”

Section: Discussionsupporting

confidence: 92%

Impact of Methionine Synthase Gene and Methylenetetrahydrofolate Reductase Gene Polymorphisms on the Risk of Sudden Sensorineural Hearing Loss

Gross¹,

Friedman

Eliashar³

et al. 2006

Audiol Neurotol

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Idiopathic sudden sensorineural hearing loss (SSNHL) represents a frequently encountered otological disease of unknown etiology. In recent years, several inherited risk factors have been found in the pathogenesis of vascular diseases. In the present study, we determined whether specific polymorphism or the combination of polymorphisms in folate-dependent homocysteine metabolism genes can act as predisposing inherited vascular risk factors in the development of SSNHL. We conducted a prospective case-control study using DNA samples extracted from 81 patients diagnosed as suffering from SSNHL and 264 healthy control subjects. Three functional polymorphisms were analyzed by polymerase chain reaction amplification, restriction enzyme digestion, and DNA fragment separation by electrophoresis: methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and methionine synthase (MTR) A2756G polymorphisms. The prevalence of the homozygous genotype of MTR 2756GG in the SSNHL patients (9%) was significantly higher than in the control group (4%) (p = 0.011). The allelic frequency of the G allele of the MTR A2756G polymorphism among SSNHL patients (12.5%) was also significantly higher than in the control group (5%) (p = 0.033). The prevalence of patients possessing two polymorphisms (31%) and three polymorphisms (17%) in the SSNHL group was significantly higher than in the control group (23 and 9%, respectively; p = 0.019). The frequency of patients with a very high rank risk (double homozygous) was significantly higher in the SSNHL group, MTHFR 677TT/MTR 2675GG – 7%, than the frequency of patients in the control group, MTHFR 677TT/MTR 2675GG – 3% (p = 0.030). Certain polymorphisms in genes encoding enzymes in the folate-dependent homocysteine metabolism are associated with SSNHL. In our case-control study, a significant association between MTR 2756GG genotype and SSNHL was found which may represent an inherited vascular risk factor in the pathogenesis of SSNHL.

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“…4 MTHFR 677CϾT and 1298AϾC polymorphisms have been identified in healthy subjects, 5 with a high frequency in Northern Italy, 6,7 and also in patients with vascular diseases known to have thrombosis as an etiology such as, venous and arterial thromboembolism, 8,9 coronary artery disease, 10,11,12 and spontaneous abortion. 13,14 To the best of our knowledge, among prothrombotic risk factors, only the prothrombin 20210GϾA gene mutation 2 and platelet GPIa807CϾT polymorphism 15 have been recently considered as risk factors for hearing loss in young patients. On the basis of these findings, genetic studies provide a possible new approach to investigating the pathogenesis of sudden hearing loss.…”

mentioning

confidence: 99%

Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms

Capaccio

Ottaviani

Cuccarini

et al. 2005

Genetics in Medicine

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Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss

Cited by 28 publications

References 46 publications

Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

Impact of Methionine Synthase Gene and Methylenetetrahydrofolate Reductase Gene Polymorphisms on the Risk of Sudden Sensorineural Hearing Loss

Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms

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