Platelet glutathione peroxidase and monoamine oxidase activity in schizophrenics with CT scan abnormalities: Relation to psychosocial variables

Buckman, Trent D.; Kling, Arthur; Sutphin, Mary S.; Steinberg, Allen; Eiduson, Samuel

doi:10.1016/0165-1781(90)90103-c

Cited by 63 publications

(22 citation statements)

References 33 publications

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“…In a study reported by Buckman et al, low peripheral GSH-Px activity was found to be associated with both cortical sulcal prominence on computed tomography and prominent negative symptoms. 32 The present study shows a relative deficiency in antioxidants and subsequent oxidative stress during the acute phase of neuroleptic syndrome, resulting in a relative defect in antioxidant/oxidant balance. Plasma TAR includes the antioxidant effects of all the antioxidants in the plasma including albumin, haptoglobin, uric acid, and vitamin E, together with other, undefined substances.…”

Section: Discussionmentioning

confidence: 99%

Total antioxidant response in patients with schizophrenia

Üstündağ¹,

Atmaca

Kirtaş

et al. 2006

Psychiatry Clin Neurosci

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There is a large amount of convincing data demonstrating that reactive oxygen species (ROS) are involved in initiation and development of many different forms of neuropsychiatric disorders. The levels of oxidants and antioxidants in schizophrenia have been evaluated. However, measurements of total antioxidant response (TAR) were not evaluated up to now. Therefore, the objectives of this study are to investigate plasma TAR levels in schizophrenia subtypes. A total of 76 patients with schizophrenia and 25 healthy volunteers were included in the study. Positive and Negative Syndrome Scale (SANS and SAPS, respectively) were applied to patients. TAR values were determined in the plasma of normal healthy controls and patients with schizophrenia. Plasma TAR levels of each schizophrenia subtype were significantly lower than healthy controls (P < 0.01 for disorganized, residual and undifferentiated subtypes and P < 0.01 for paranoid subtype). When intragroup comparisons were performed, paranoid subtype had higher plasma TAR levels compared to other subtypes (P < 0.01). Accordingly, as a whole group, patients with schizophrenia had lower plasma TAR levels compared to controls. Plasma TAR levels were significantly and negatively correlated with SANS scores, and duration of illness was evaluated but not related to other parameters. Consequently, the present study further emphasizes the growing consideration that free radical damage may have an important etiopathogenetic role on the development of schizophrenia and suggests that decreased plasma total antioxidant levels may be related to the progression of illness.

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Section: Discussionmentioning

confidence: 99%

Total antioxidant response in patients with schizophrenia

Üstündağ¹,

Atmaca

Kirtaş

et al. 2006

Psychiatry Clin Neurosci

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“…Of these, the one that showed the greatest decrease in NAA [26] was the only one that corrected for varying gray matter content, which has been shown to improve ability to detect changes [27]. Since cortical atrophy has been measured in schizophrenia [12], correction for neuron and water content could increase our ability to measure changes. Techniques that have been proposed for such correction include brain tissue segmentation, external referencing, and assessment of water compartmentalization via measurement of water signal at multiple echo times [28].…”

Section: Discussionmentioning

confidence: 99%

“…GSH and ascorbate are the most concentrated non-enzymatic antioxidants in the central nervous system [10]. Studies suggest that oxidative stress [11] and altered activity of GSH peroxidase, an important antioxidant enzyme [12] may be involved in the pathogenesis of schizophrenia [9]. Additional metabolites of interest in the study of schizophrenia, such as glutamate and glutamine can be quantified concurrently with GSH from short-echo time STEAM spectra [13].…”

Section: Introductionmentioning

confidence: 99%

Validation of glutathione quantitation from STEAM spectra against edited 1H NMR spectroscopy at 4T: application to schizophrenia

Terpstra

Vaughan

Uğurbil

et al. 2005

MAGMA

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Objective: Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinically relevant population using the resolved GSH resonances provided by edited spectroscopy. A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control. Materials and Methods: GSH was quantified at 4T from short echo STEAM spectra and MEGA-PRESS edited spectra from identical volumes of interest (anterior cingulate) in ten volunteers. Neurochemical profiles were quantified in nine controls and 13 medicated schizophrenic patients. Results: GSH concentrations as quantified using STEAM, 1.6 ± 0.4 µmol/g (mean ± SD, n = 10), were within error of those quantified using edited spectra, 1.4 ± 0.4 µmol/g, and were not different (p = 0.4). None of the neurochemical measurements reached sufficient statistical power to detect differences smaller than 10% in schizophrenia versus control. As such, no differences were observed. Conclusions: Human brain GSH concentrations can be quantified in a clinical setting using short-echo time STEAM spectra at 4T.

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“…Levels of other antioxidants, including glutathione peroxidase (GSH-Px), also have been implicated (Abdalla et al, 1986;Stoklasová et al, 1986;Buckman et al, 1987;Altuntas et al, 2000). It has been suggested that low GSH-Px is a contributing factor to structural brain abnormalities (Buckman et al, 1990;Yao and Reddy, 2011). Several studies have reported that patients with bipolar disorder have significant alterations in antioxidant enzymes, lipid peroxidation, and nitric oxide levels (Andreazza et al, 2008), suggesting the role of free radicals and antioxidants in the pathophysiology of bipolar disorder Magalhães et al, 2011;Sarris et al, 2011).…”

Section: Oxidative Stress and Neuropsychiatric Disordersmentioning

confidence: 99%